{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:45:26Z","timestamp":1787024726786,"version":"build-2736575974"},"reference-count":181,"publisher":"JMIR Publications Inc.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Internet Res"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sepsis is a significant cause of morbidity and mortality worldwide. Early detection of sepsis followed promptly by treatment initiation improves patient outcomes and saves lives. Hospitals are increasingly using computerized clinical decision support (CCDS) systems for the rapid identification of adult patients with sepsis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This scoping review aims to systematically describe studies reporting on the use and evaluation of CCDS systems for the early detection of adult inpatients with sepsis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The protocol for this scoping review was previously published. A total of 10 electronic databases (MEDLINE, Embase, CINAHL, the Cochrane database, LILACS [Latin American and Caribbean Health Sciences Literature], Scopus, Web of Science, OpenGrey, ClinicalTrials.gov, and PQDT [ProQuest Dissertations and Theses]) were comprehensively searched using terms for sepsis, CCDS, and detection to identify relevant studies. Title, abstract, and full-text screening were performed by 2 independent reviewers using predefined eligibility criteria. Data charting was performed by 1 reviewer with a second reviewer checking a random sample of studies. Any disagreements were discussed with input from a third reviewer. In this review, we present the results for adult inpatients, including studies that do not specify patient age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A search of the electronic databases retrieved 12,139 studies following duplicate removal. We identified 124 studies for inclusion after title, abstract, full-text screening, and hand searching were complete. Nearly all studies (121\/124, 97.6%) were published after 2009. Half of the studies were journal articles (65\/124, 52.4%), and the remainder were conference abstracts (54\/124, 43.5%) and theses (5\/124, 4%). Most studies used a single cohort (54\/124, 43.5%) or before-after (42\/124, 33.9%) approach. Across all 124 included studies, patient outcomes were the most frequently reported outcomes (107\/124, 86.3%), followed by sepsis treatment and management (75\/124, 60.5%), CCDS usability (14\/124, 11.3%), and cost outcomes (9\/124, 7.3%). For sepsis identification, the systemic inflammatory response syndrome criteria were the most commonly used, alone (50\/124, 40.3%), combined with organ dysfunction (28\/124, 22.6%), or combined with other criteria (23\/124, 18.5%). Over half of the CCDS systems (68\/124, 54.8%) were implemented alongside other sepsis-related interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The current body of literature investigating the implementation of CCDS systems for the early detection of adult inpatients with sepsis is extremely diverse. There is substantial variability in study design, CCDS criteria and characteristics, and outcomes measured across the identified literature. Future research on CCDS system usability, cost, and impact on sepsis morbidity is needed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>International Registered Report Identifier (IRRID)<\/jats:title>\n                    <jats:p>RR2-10.2196\/24899<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2196\/31083","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T17:17:21Z","timestamp":1635527841000},"page":"e31083","source":"Crossref","is-referenced-by-count":31,"title":["Computerized Clinical Decision Support Systems for the Early Detection of Sepsis Among Adult Inpatients: Scoping Review"],"prefix":"10.2196","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9868-9456","authenticated-orcid":false,"given":"Khalia","family":"Ackermann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2208-6584","authenticated-orcid":false,"given":"Jannah","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6055-9592","authenticated-orcid":false,"given":"Malcolm","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7739-1658","authenticated-orcid":false,"given":"Mary","family":"Fullick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9411-0053","authenticated-orcid":false,"given":"Hilal","family":"Varinli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1083-8192","authenticated-orcid":false,"given":"Johanna","family":"Westbrook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1642-142X","authenticated-orcid":false,"given":"Ling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1010","published-online":{"date-parts":[[2022,2,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32989-7"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1553"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181d8cc1d"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000001658"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2013.01.017"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-1048-2"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"164","DOI":"10.52964\/AMJA.0678","volume":"16","author":"Alam, N","year":"2017","journal-title":"Acute Med"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1208623"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1703058"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003342"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-017-4683-6"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2196\/15166"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30696-2"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2016.12.53"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201604-0854OC"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0288"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/imj.14746"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.06.020"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-014-0529-6"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1695717"},{"issue":"6","key":"ref22","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1002\/jhm.2347","volume":"10","author":"Makam, AN","year":"2015","journal-title":"J Hosp Med"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038\/s41746-020-0221-y"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1093\/jamia\/ocaa319"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-018-1050-6"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.2196\/24899"},{"key":"ref27","author":"Peters, M","year":"2020","journal-title":"JBI Manual for Evidence Synthesis"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.7326\/M18-0850"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1080\/1364557032000119616"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1186\/s12978-017-0321-6"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000583"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31002-4"},{"key":"ref33","unstructured":"Ergonomics of human-system interaction - Part 11: usability: definitions and concepts. ISO standard no. 9241-11:2018(EN)The International Organization for Standardization20182021-02-26https:\/\/www.iso.org\/obp\/ui\/#iso:std:iso:9241:-11:ed-2:v1:en"},{"key":"ref34","author":"Viswanathan, M","year":"2013","journal-title":"AHRQ Methods for Effective Health Care"},{"issue":"4","key":"ref35","doi-asserted-by":"crossref","first-page":"184","DOI":"10.4103\/picr.PICR_124_18","volume":"9","author":"Ranganathan, P","year":"2018","journal-title":"Perspect Clin Res"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.4103\/picr.PICR_154_18"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.4103\/picr.PICR_35_19"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.4103\/picr.PICR_91_19"},{"issue":"4","key":"ref39","doi-asserted-by":"crossref","first-page":"183","DOI":"10.4103\/picr.PICR_138_19","volume":"10","author":"Aggarwal, R","year":"2019","journal-title":"Perspect Clin Res"},{"key":"ref40","unstructured":"Clinical score usefulness and EHR integration (ScoreInt)ClinicalTrials.gov identifier: NCT0275502520170329https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02755025 [accessed 2020-08-17]"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmedinf.2017.04.001"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.2196\/humanfactors.7567"},{"key":"ref43","unstructured":"AcquahSStollerMHellerMKrupkaMWangCSmithMKriegerPUtilizing electronic alerts and IVC ultrasound to improve outcomes for sepsis care in an urban EDProceedings of the American Thoracic Society International Conference, ATS 20142014American Thoracic Society International Conference, ATS 2014May 16-21, 2014San Diego, CA United States"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003919"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1186\/s12911-014-0105-7"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1177\/1062860614557636"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1177\/1062860615606801"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1177\/1062860617692034"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1093\/jamiaopen\/ooy013"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-017-0280-7"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1093\/jamia\/ocx072"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.5644\/ama2006-124.212"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1111\/acem.13424"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1097\/DCC.0000000000000046"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.4338\/ACI-2010-09-RA-0054"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccm.0000424701.89139.e0"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccm.0000552367.92747.7a"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1177\/1062860614541291"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1186\/s12873-016-0095-0"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1097\/NCQ.0b013e3182a98182"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccm.0000458463.39133.b9"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1177\/1751143718767059"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000470325.07465.0f"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.21037\/mhealth.2019.09.04"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1111\/acem.13961"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000000121"},{"key":"ref67","unstructured":"DanakVTo improve sensitivity and specificity in early detection of sepsis in patients [Dissertation]University of California, Davis20142020-09-18https:\/\/www.proquest.com\/docview\/1665309377\/abstract\/403F4AE572954DA6PQ\/"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1136\/bmjqs-2018-008765"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1016\/j.jen.2013.08.009"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1186\/s12911-016-0396-y"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-009-1004-1"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccm.0000458480.24778.4d"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2016.08.161"},{"key":"ref74","unstructured":"ErenGTekdosYDoganMAcicbeOKayaEHergunselOSeptic shock alert over SIRS criteria has an impact on outcome but needs to be revisedProceedings of the 36th International Symposium on Intensive Care and Emergency Medicine201636th International Symposium on Intensive Care and Emergency MedicineMarch 15-18, 2016Brussels, Belgium"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.181418"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2016.29005.abstracts"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1111\/acem.12365"},{"key":"ref78","unstructured":"FogertyRSankeyCKenyonKSussmanSAckerKSigurdssonSKligerAPilot of a low-resource, EHR-based protocol for sepsis monitoring, alert, and interventionProceedings of the 39th Annual Meeting of the Society of General Internal Medicine, SGIM 2016201639th Annual Meeting of the Society of General Internal Medicine, SGIM 2016May 11-14, 2016Hollywood, FL United States"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1097\/PTS.0000000000000463"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1136\/bmjqs-2014-003552"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1378\/chest.1118563"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm-conference.2011.183.1_meetingabstracts.a4696"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm-conference.2011.183.1_meetingabstracts.a3860"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1186\/cc10102"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2014.07.139"},{"issue":"3","key":"ref86","first-page":"177","volume":"30","author":"Gille, J","year":"2017","journal-title":"Ann Burns Fire Disasters"},{"key":"ref87","unstructured":"GowdaSSHooperMWeavindLNianHWheelerAModified systemic inflammatory response syndrome (MSIRS) score and risk of mortality in medical intensive care unit (MICU) patientsProceedings of the Critical Care Congress 20122012Critical Care Congress 2012February 4-8, 2012Houston, TX, United States154"},{"key":"ref88","unstructured":"GowdaSSNianHWeavindLModified SIRS criteria in peri-operative patients admitted to surgical intensive care unit: clinical course and outcomeProceedings of the Critical Care Congress 20122012Critical Care Congress 2012February 4-8, 2012Houston, TX, United States154"},{"key":"ref89","doi-asserted-by":"publisher","DOI":"10.1177\/1062860616676887"},{"key":"ref90","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201503-129OC"},{"key":"ref91","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2017.04.005"},{"key":"ref92","unstructured":"HarrisonAMDevelopment, testing, and refining the failure to rescue sepsis sniffer [Dissertation]College of Medicine, Mayo Clinic20152020-09-18https:\/\/www.proquest.com\/openview\/d6cf865a3f8eb3c4ed3583317f9ff53b\/1?pq-origsite=gscholar&cbl=18750"},{"key":"ref93","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.3083"},{"key":"ref94","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2015.08.039"},{"key":"ref95","doi-asserted-by":"publisher","DOI":"10.1136\/amiajnl-2011-000228"},{"key":"ref96","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2017.04.005"},{"key":"ref97","doi-asserted-by":"publisher","DOI":"10.1093\/jamia\/ocz186"},{"key":"ref98","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm-conference.2010.181.1_meetingabstracts.a6137"},{"key":"ref99","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm-conference.2011.183.1_meetingabstracts.a5848"},{"key":"ref100","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318250a887"},{"key":"ref101","doi-asserted-by":"publisher","DOI":"10.1093\/jamiaopen\/ooaa014"},{"key":"ref102","doi-asserted-by":"publisher","DOI":"10.1097\/NCQ.0000000000000384"},{"key":"ref103","doi-asserted-by":"publisher","DOI":"10.1097\/JHQ.0000000000000193"},{"key":"ref104","doi-asserted-by":"publisher","DOI":"10.1016\/s1553-7250(15)41063-3"},{"key":"ref105","doi-asserted-by":"publisher","DOI":"10.1177\/1060028014541792"},{"key":"ref106","unstructured":"JukesTUsing clinical decision support to assist in identification of severe sepsis: design development and implementation of an automated sepsis prompt [Dissertation]University of California, Davis20132020-09-18https:\/\/www.proquest.com\/docview\/1449817718?"},{"key":"ref107","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2018.05.078"},{"key":"ref108","doi-asserted-by":"publisher","DOI":"10.1177\/1054773818823334"},{"key":"ref109","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2013.07.087"},{"key":"ref110","doi-asserted-by":"publisher","DOI":"10.1097\/CNQ.0000000000000060"},{"key":"ref111","unstructured":"LawsonLUse of clinical decision algorithms on medical surgical units to assist in the identification and care of patients at risk for acquiring sepsis [Dissertation]Northcentral University20172020-09-18https:\/\/www.proquest.com\/openview\/9de3653d06b2e4128ccde607b239edf2\/1?pq-origsite=gscholar&cbl=18750&diss=y"},{"key":"ref112","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccm.0000528984.10458.e7"},{"key":"ref113","doi-asserted-by":"publisher","DOI":"10.1097\/JHQ.0000000000000166"},{"key":"ref114","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccm.0000458478.79036.7c"},{"key":"ref115","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2013.07.456"},{"key":"ref116","doi-asserted-by":"publisher","DOI":"10.1186\/cc14025"},{"key":"ref117","unstructured":"McCabePTeamRThorneJSarumiMRyanARappaportHM2SEWS early warning systems and proactive screening provides early intervention and escalates careProceedings of the 45th Critical Care Congress of the Society of Critical Care Medicine, SCCM 2015201545th Critical Care Congress of the Society of Critical Care Medicine, SCCM 2015February 20-24, 2016Orlando, FL, United States2767"},{"key":"ref118","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccm.0000390903.16849.8c"},{"key":"ref119","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrtlng.2014.05.009"},{"key":"ref120","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2008.02094.x"},{"issue":"3","key":"ref121","volume":"1","author":"Miller, K","year":"2017","journal-title":"Am J Hosp Med"},{"key":"ref122","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2018.228"},{"key":"ref123","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2015.10.005"},{"key":"ref124","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2010.12.008"},{"key":"ref125","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2012.06.332"},{"key":"ref126","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.343"},{"key":"ref127","unstructured":"NoonanTZDecision making under uncertainty in the emergency department: studying the effects of cognitive biases in the diagnosis of sepsis [Dissertation]The University of Iowa20182020-09-18https:\/\/www.proquest.com\/openview\/56541ec710f706fd3432237557287af3\/1?pq-origsite=gscholar&cbl=18750"},{"key":"ref128","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2014.07.180"},{"key":"ref129","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccm.0000440308.10021.b8"},{"key":"ref130","doi-asserted-by":"publisher","DOI":"10.1378\/chest.2274431"},{"key":"ref131","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjq.2020.04.006"},{"key":"ref132","doi-asserted-by":"publisher","DOI":"10.1016\/j.cnc.2018.02.011"},{"issue":"2","key":"ref133","first-page":"27","volume":"32","author":"Pham, T","year":"2012","journal-title":"Critical Care Nurse"},{"key":"ref134","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccm.0000458488.62896.96"},{"key":"ref135","doi-asserted-by":"publisher","DOI":"10.1111\/acem.12974"},{"key":"ref136","doi-asserted-by":"publisher","DOI":"10.1186\/cc12457"},{"key":"ref137","doi-asserted-by":"publisher","DOI":"10.1097\/CIN.0000000000000355"},{"key":"ref138","unstructured":"SalamahMThagafiMReidyMDiknashSAl-QahtaniSMariniAMahmoudASohailMAlhunaidiFFarooquiFAlamryAAl-AttasKTaherSArabiYMThe predictive value of an electronic alert system for severe sepsis and septic shockProceedings of the American Thoracic Society International Conference, ATS 20132013American Thoracic Society International Conference, ATS 2013May 17-22, 2013Philadelphia, PA, United States"},{"key":"ref139","unstructured":"SankeyCSussmanLSKenyonKLiFSukumarNKligerAFogertyRLPilot of a low-resource, EHR-based tool for sepsis monitoring, alert, and interventionProceedings of the 40th Annual Meeting of the Society of General Internal Medicine, SGIM 2017201740th Annual Meeting of the Society of General Internal Medicine, SGIM 2017April 19-22, 2017Washington, DC, United States"},{"key":"ref140","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2017.07.296"},{"key":"ref141","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccm.0000440317.37837.1c"},{"key":"ref142","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318205df85"},{"key":"ref143","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2019.01.032"},{"key":"ref144","doi-asserted-by":"publisher","DOI":"10.1111\/acem.12974"},{"key":"ref145","doi-asserted-by":"publisher","DOI":"10.1111\/acem.12974"},{"key":"ref146","doi-asserted-by":"publisher","DOI":"10.1111\/acem.12365"},{"key":"ref147","doi-asserted-by":"publisher","DOI":"10.1111\/1742-6723.13748"},{"key":"ref148","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8111800"},{"key":"ref149","unstructured":"SwensonKFergusonJShiehLRogersAAttitudes and perceptions of medical trainees towards an electronic medical alert system for sepsisProceedings of the American Thoracic Society International Conference, ATS 20182018American Thoracic Society International Conference, ATS 2018May 18-23, 2018San Diego, CA, United States"},{"key":"ref150","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm-conference.2019.199.1_MeetingAbstracts.A7173"},{"key":"ref151","doi-asserted-by":"publisher","DOI":"10.1177\/147323001003800505"},{"key":"ref152","doi-asserted-by":"publisher","DOI":"10.1097\/00024665-200301000-00009"},{"key":"ref153","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2015.07.287"},{"issue":"1","key":"ref154","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/jhm.2259","volume":"10","author":"Umscheid, CA","year":"2015","journal-title":"J Hosp Med"},{"key":"ref155","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofx163.1333"},{"key":"ref156","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2015.069"},{"issue":"4","key":"ref157","doi-asserted-by":"crossref","first-page":"414","DOI":"10.5935\/0103-507X.20180059","volume":"30","author":"Westphal, GA","year":"2018","journal-title":"Rev Bras Ter Intensiva"},{"key":"ref158","unstructured":"WinterbottomFEarly warning: detecting sepsis in every patient, every shift requires timely vital sign documentationProceedings of the Ochsner 13th Annual Research Day Abstracts2016Ochsner 13th Annual Research Day AbstractsMay 17, 2016New Orleans, LA, United States398"},{"key":"ref159","unstructured":"WolpawBKressNGrantRWahlDGarver-HumeAVillanuevaSChenACarlbomDEHR-based sepsis warning system improves detection and treatment of hospital-acquired sepsis in an acute care hospital settingProceedings of the 41st Annual Meeting of the Society of General Internal Medicine, SGIM 2018201841st Annual Meeting of the Society of General Internal Medicine, SGIM 2018April 11-14, 2018Denver, CO, United States"},{"key":"ref160","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553-2712.2012.01332.x"},{"key":"ref161","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofz360.838"},{"key":"ref162","unstructured":"ZaragozaRSanchoSHurtadoCCamarenaJGonz\u00e1lezRBorr\u00e1sSCerveraMSEPSIS SAVER. Preliminary results of a pilot implementation of a new automatic electronic alert for early detection of sepsis based on Sepsis 3 definitionProceedings of the 32nd European Society of Intensive Care Medicine Annual Congress, ESICM 2019201932nd European Society of Intensive Care Medicine Annual Congress, ESICM 2019September 28 - October 2, 2019Berlin, Germany"},{"key":"ref163","doi-asserted-by":"publisher","DOI":"10.21767\/2471-8505.100049"},{"key":"ref164","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2020.02.022"},{"key":"ref165","doi-asserted-by":"publisher","DOI":"10.1097\/JHQ.0000000000000066"},{"key":"ref166","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012404.pub2"},{"key":"ref167","doi-asserted-by":"publisher","DOI":"10.2196\/10264"},{"key":"ref168","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgh-2018-000899"},{"key":"ref169","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.323.7313.625"},{"key":"ref170","doi-asserted-by":"publisher","DOI":"10.2196\/jmir.8775"},{"key":"ref171","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2016.11.006"},{"key":"ref172","author":"Torio, C","year":"2013","journal-title":"Healthcare Cost and Utilization Project (HCUP) Statistical Briefs"},{"key":"ref173","first-page":"327","volume":"136","author":"Peute, LW","year":"2008","journal-title":"Stud Health Technol Inform"},{"key":"ref174","doi-asserted-by":"publisher","DOI":"10.1093\/jamia\/ocx118"},{"key":"ref175","doi-asserted-by":"publisher","DOI":"10.1177\/1460458218813732"},{"key":"ref176","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2016.01.004"},{"key":"ref177","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(18)30072-9"},{"key":"ref178","doi-asserted-by":"publisher","DOI":"10.2196\/medinform.8912"},{"key":"ref179","doi-asserted-by":"publisher","DOI":"10.1186\/cc4821"},{"key":"ref180","doi-asserted-by":"publisher","DOI":"10.5811\/westjem.2015.9.27348"},{"key":"ref181","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare6030090"}],"container-title":["Journal of Medical Internet Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jmir.org\/2022\/2\/e31083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T17:47:39Z","timestamp":1782841659000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jmir.org\/2022\/2\/e31083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,23]]},"references-count":181,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.2196\/31083","relation":{"has-preprint":[{"id-type":"doi","id":"10.2196\/preprints.31083","asserted-by":"object"}]},"ISSN":["1438-8871"],"issn-type":[{"value":"1438-8871","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,23]]}}}