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However, conceptual models to guide hypotheses and interpretation of results from digital tools are lacking and are needed to sort and organize the large amount of continuous data from a variety of sensors. In this viewpoint, we propose a neuropsychological framework for use alongside a key emerging approach\u2014digital phenotyping. The Variability in Everyday Behavior (VIBE) model is rooted in established trends from the neuropsychology, neurology, rehabilitation psychology, cognitive neuroscience, and computer science literature and links patterns of intraindividual variability, cognitive abilities, and everyday functioning across clinical stages from healthy to dementia. Based on the VIBE model, we present testable hypotheses to guide the design and interpretation of digital phenotyping studies that capture everyday cognition in vivo. We conclude with methodological considerations and future directions regarding the application of the digital phenotyping approach to improve the efficiency, accessibility, accuracy, and ecological validity of cognitive assessment in older adults.<\/jats:p>","DOI":"10.2196\/38130","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T09:30:35Z","timestamp":1662543035000},"page":"e38130","source":"Crossref","is-referenced-by-count":27,"title":["Capturing Cognitive Aging in Vivo: Application of a Neuropsychological Framework for Emerging Digital 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