{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T18:02:20Z","timestamp":1782842540233,"version":"3.54.5"},"reference-count":24,"publisher":"JMIR Publications Inc.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMIR Form Res"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Granville and Vance counties have some of the highest opioid-related death rates in North Carolina, and have significant unmet needs with regard to opioid treatment. Medication for opioid use disorder (MOUD) is the most effective evidence-based approach to address opioid use disorder. Despite demonstrated efficacy and substantial need, access to MOUD is still insufficient in many parts of the United States. In order to connect patients with needed MOUD services, the district health department, Granville Vance Public Health (GVPH), established an office-based opioid treatment (OBOT) program.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>In this formative pilot study, we sought to describe patients\u2019 goals and outcomes in a program delivered at a rural local health department using an integrated care approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used a mixed methods concurrent nested research design. The primary method of investigation was one-on-one qualitative interviews with active OBOT patients (n=7) focused on patients\u2019 goals and perceived impacts of the program. Trained interviewers followed a semistructured interview guide developed iteratively by the study team. The secondary method was a descriptive quantitative analysis (79 patients; 1478 visits over 2.5 years) of treatment retention and patient-reported outcomes (anxiety and depression).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Participants in the OBOT program were 39.6 years of age on average, and 25.3% (20\/79) were uninsured. The average retention in the program was 18.4 months. The proportion of individuals in the program with moderate to severe depression (Patient Health Questionnaire-9 scores \u226510) decreased between program initiation (66%, 23\/35) and at the most recent assessment (34%, 11\/32). In qualitative interviews, participants credited the OBOT program for reducing or stopping the use of opioids and other substances (eg, marijuana, cocaine, and benzodiazepines). Many participants noted how the program helped them manage withdrawal symptoms and cravings, which helped them feel more in control of their use. Participants also attributed improvements in quality of life to the OBOT program, such as improved relationships with loved ones, improved mental and physical health, and improved financial stability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Initial data show promising patient outcomes for active GVPH OBOT participants, including reduction in opioid use and improvements in quality of life. As a pilot study, a limitation of this study is a lack of a comparison group. However, this formative project demonstrates promising patient-centered outcome improvements for GVPH OBOT participants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2196\/40897","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T05:02:29Z","timestamp":1679547749000},"page":"e40897","source":"Crossref","is-referenced-by-count":1,"title":["Patient-Centered Outcomes Associated With a Novel Office-Based Opioid Treatment Program in a District Health Department: Mixed Methods Pilot Study"],"prefix":"10.2196","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2941-8999","authenticated-orcid":false,"given":"Theresa","family":"Coles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8272-1941","authenticated-orcid":false,"given":"Hillary","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2914-0109","authenticated-orcid":false,"given":"Andrea","family":"Des Marais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2632-5214","authenticated-orcid":false,"given":"Nidhi","family":"Sachdeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5375-6459","authenticated-orcid":false,"given":"Christopher","family":"Bush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2386-4269","authenticated-orcid":false,"given":"Lisa","family":"Macon Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3981-7171","authenticated-orcid":false,"given":"Shauna","family":"Guthrie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1010","published-online":{"date-parts":[[2023,5,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.20622"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.7326\/M17-3107"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/HRP.0000000000000075"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2196\/32133"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/jrh.12503"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1370\/afm.1735"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2196\/18734"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.20900\/jpbs.20200003"},{"key":"ref9","unstructured":"2018 Granville vance community health assessmentGranville County Health Department20182023-04-05https:\/\/gvph.org\/wp-content\/uploads\/2019\/03\/GVPH-2018-CHA-Report-Final-no-appendices.pdf"},{"key":"ref10","unstructured":"Quick facts: North Carolina; Vance County, North Carolina; Granville County, North CarolinaUnited States Census Bureau20212023-04-05https:\/\/www.census.gov\/quickfacts\/fact\/table\/NC,vancecountynorthcarolina,granvillecountynorthcarolina\/PST045219"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.6373"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-021-06904-4"},{"key":"ref13","unstructured":"Principles of harm reductionNational Harm Reduction Coalition20212023-04-05https:\/\/harmreduction.org\/about-us\/principles-of-harm-reduction\/"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1177\/1049732305276687"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.2001.016009606.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.10.1092"},{"key":"ref17","unstructured":"Models for medication-assisted treatment for opioid use disorder, retention, and continuity of careOffice of the Assistant Secretary for Planning and Evaluation20202023-04-05https:\/\/aspe.hhs.gov\/sites\/default\/files\/migrated_legacy_files\/\/195116\/MATOUDModels.pdf"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1001\/jama.1995.03520250075037","volume":"273","author":"Wilson, IB","year":"1995","journal-title":"JAMA"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2014.05.006"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2021.108784"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1037\/ccp0000399"},{"key":"ref22","unstructured":"RipleyDMCounseling interventions and buprenorphine for treatment of opioid use disorders [dissertation]Virginia Polytechnic Institute and State University20192023-04-05https:\/\/vtechworks.lib.vt.edu\/bitstream\/handle\/10919\/88809\/Ripley_DM_D_2019.pdf?sequence=1&isAllowed=y"},{"key":"ref23","unstructured":"ChenHDes MaraisAGuthrieSHarrisonLMSachdevaNColesTPractical guidance for implementation of office-based opioid treatment through primary care at local health departmentsDepartment of Population Health Sciences20222023-04-05https:\/\/populationhealth.duke.edu\/sites\/default\/files\/2022-09\/PracticalGuidanceforImplementingOBOT.pdf"},{"key":"ref24","unstructured":"Academic health department partnershipsPublic Health Foundation20222023-04-05https:\/\/www.phf.org\/programs\/AHDLC\/Pages\/Academic_Health_Departments.aspx"}],"container-title":["JMIR Formative Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/formative.jmir.org\/2023\/1\/e40897","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T17:39:55Z","timestamp":1782841195000},"score":1,"resource":{"primary":{"URL":"https:\/\/formative.jmir.org\/2023\/1\/e40897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,24]]},"references-count":24,"URL":"https:\/\/doi.org\/10.2196\/40897","relation":{"has-preprint":[{"id-type":"doi","id":"10.2196\/preprints.40897","asserted-by":"object"}]},"ISSN":["2561-326X"],"issn-type":[{"value":"2561-326X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,24]]}}}