{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:45:22Z","timestamp":1792097122022,"version":"4.4.0"},"reference-count":7,"publisher":"JMIR Publications Inc.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMIR Diabetes"],"abstract":"\n Background<\/jats:title>\n For patients with type 2 diabetes (T2D), calculating the daily dose of basal insulin may be challenging. Insulia is a digital remote monitoring solution that uses clinical algorithms to recommend basal insulin doses. A predecessor device was evaluated in the TeleDiab-2 randomized controlled trial, showing that a higher percentage of patients using the app achieved their target fasting blood glucose (FBG) level compared to the control group, and insulin doses were adjusted to higher levels without hypoglycemia.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n This study aims to analyze how the glycemic control of Insulia users has evolved when using the app in a real-life setting in France.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A retrospective observational analysis of data collected through the device in adult French patients with T2D treated with basal insulin and oral antihyperglycemic agents using the system for \u22656 months was conducted. Analyses were descriptive and distinguished the results in a subpopulation of regular and compliant users of the app. Glycemic outcomes were estimated considering the percentage of patients who achieved their individualized FBG target between 5.5 and 6 months following the initiation of device use, the frequency of hypoglycemia resulting in a treatment change over the 6-month period of exposure, and the evolution of the average hemoglobin A1c (HbA1c) level over the same period.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Of the 484 users, 373 (77.1%) performed at least one dose calculation. A total of 221 (59.2%) users were men. When app use started, the mean age, BMI, HbA1c, and basal insulin dose were 55.8 (SD 11.9) years, 30.6 (SD 5.9) kg\/m2, 10.1% (SD 2.0%), and 25.5 (SD 15.8) IU\/day, respectively. Over a median use duration of 5.0 (95% CI 3.8-5.7) months, patients used the system 5.8 (SD 1.6) times per week on average, and 73.4% of their injected doses were consistent with the app\u2019s suggested doses. Among regular and compliant user patients (n=91, \u22655 measurements\/week and \u226580% adherence to calculated doses), 60% (55\/91) achieved the FBG target (\u00b15%) at 6 months (5.5-6 months) versus 51.5% (145\/282) of the other patients (P=.15). There was an increase in the proportion of patients achieving their target FBG for regular and compliant users (+1.86% every 2 weeks) without clear improvement in other patients. A logistic model did not identify the variables that were significantly associated with this outcome among regular and compliant users. In the overall population, the incidence of reported hypoglycemia decreased simultaneously (\u20130.16%\/month). Among 82 patients, the mean HbA1c decreased from 9.9% to 7.2% at 6 months.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n An improvement in glycemic control as measured by the percentage of patients reaching their FBG individualized target range without increasing hypoglycemic risk was observed in patients using the Insulia app, especially among regular users following the dose recommendations of the algorithm.<\/jats:p>\n <\/jats:sec>","DOI":"10.2196\/44277","type":"journal-article","created":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T08:28:20Z","timestamp":1675412900000},"page":"e44277","source":"Crossref","is-referenced-by-count":8,"title":["The Effectiveness of an App (Insulia) in Recommending Basal Insulin Doses for French Patients With Type 2 Diabetes Mellitus: Longitudinal Observational Study"],"prefix":"10.2196","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5485-1535","authenticated-orcid":false,"given":"Camille","family":"Nevoret","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9330-0341","authenticated-orcid":false,"given":"Nathalie","family":"Gervaise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4320-2601","authenticated-orcid":false,"given":"Brigitte","family":"Delemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7520-7493","authenticated-orcid":false,"given":"Said","family":"Bekka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7843-4608","authenticated-orcid":false,"given":"Bruno","family":"Detournay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4311-7543","authenticated-orcid":false,"given":"Amine","family":"Benkhelil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4548-5059","authenticated-orcid":false,"given":"Amar","family":"Bahloul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7392-0874","authenticated-orcid":false,"given":"Genevi\u00e8ve","family":"d'Orsay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9635-7674","authenticated-orcid":false,"given":"Alfred","family":"Penfornis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1010","published-online":{"date-parts":[[2023,3,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13806"},{"key":"ref2","unstructured":"Minist\u00e8re des Solidarit\u00e9s et de la Sant\u00e9Arr\u00eat\u00e9 du 23 d\u00e9cembre 2020 portant cahiers des charges des exp\u00e9rimentations relatives \u00e0 la prise en charge par t\u00e9l\u00e9surveillance mis en \u0153uvre sur le fondement de l\u2019article 54 de la loi no 2017- 1836 de financement de la s\u00e9curit\u00e9 sociale pour 2018Minist\u00e8re de la Sant\u00e9 et de la Pr\u00e9vention202012232023-02-08https:\/\/sante.gouv.fr\/IMG\/pdf\/joe_20201230_0315_0072.pdf"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-015-0314-7"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2337\/cd20-0054"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2337\/db19-122-lb"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1177\/1932296818823020"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30368-X"}],"container-title":["JMIR Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetes.jmir.org\/2023\/1\/e44277","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T17:48:12Z","timestamp":1782841692000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetes.jmir.org\/2023\/1\/e44277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,1]]},"references-count":7,"URL":"https:\/\/doi.org\/10.2196\/44277","relation":{"has-preprint":[{"id-type":"doi","id":"10.2196\/preprints.44277","asserted-by":"object"}]},"ISSN":["2371-4379"],"issn-type":[{"value":"2371-4379","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,1]]}}}