{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T18:50:12Z","timestamp":1782845412560,"version":"3.54.5"},"reference-count":40,"publisher":"JMIR Publications Inc.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMIR Public Health Surveill"],"abstract":"\n Background<\/jats:title>\n The association between metabolic dysfunction\u2013associated fatty liver disease (MAFLD) and chronic kidney disease (CKD) is unclear.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n This longitudinal cohort study aimed to test whether MAFLD plays an important role in the development of CKD.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This cohort study included 41,246 participants who had undergone 3 or more health examinations from 2008 to 2015 at the People\u2019s Hospital of Guangxi Zhuang Autonomous Region, China. Participants were categorized into 2 groups according to whether they presented with or without MAFLD. The occurrence of new-onset CKD was stated as either an estimated glomerular filtration rate of <60 mL\/min per 1.73 m2 or a higher level of albuminuria during their follow-up appointment. The association between MAFLD and CKD was evaluated using a Cox regression method.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Of the 41,246 participants, 11,860 (28.8%) were diagnosed with MAFLD. Over the course of the 14-year follow-up (median 10.0 years), 5347 (13%) participants experienced a new incident of CKD (135.73 per 10,000 person-years). MAFLD was discovered as an important risk factor for new incidents of CKD (hazard ratio 1.18, 95% CI 1.11-1.26) by using the multivariable Cox proportional hazard regression model. When stratified by gender, the adjusted hazard ratio for the incidence of CKD in men and women with MAFLD were 1.16 (95% CI 1.07-1.26) and 1.32 (95% CI 1.18-1.48), respectively. According to the subgroup analysis results, after adjusting for confounding factors, the MAFLD-related CKD risk was greater in men aged <60 years (Pinteraction=.001) and in those with combined dyslipidemia (Pinteraction=.02), but this relationship was not found in women (all Pinteraction>.05).<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n MAFLD plays an important role in the development of new incidents of CKD in the long run.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n Chinese Clinical Trial Registry ChiCTR2200058543; https:\/\/www.chictr.org.cn\/showproj.html?proj=153109<\/jats:p>\n <\/jats:sec>","DOI":"10.2196\/45050","type":"journal-article","created":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T10:00:47Z","timestamp":1683194447000},"page":"e45050","source":"Crossref","is-referenced-by-count":12,"title":["The Role of Metabolic Dysfunction\u2013Associated Fatty Liver Disease in Developing Chronic Kidney Disease: Longitudinal Cohort 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