{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:17:50Z","timestamp":1790727470059,"version":"4.1.0"},"reference-count":39,"publisher":"JMIR Publications Inc.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Internet Res"],"abstract":"\n Background<\/jats:title>\n Although it is well known that adolescents frequently turn to their friends for support around mental health and substance use problems, there are currently no evidence-based digital programs to support them to do this.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n The aim of this study was to evaluate the efficacy of the Mind your Mate program, a digital peer-support program, in improving mental health symptoms, reducing the uptake of substance use, and increasing help seeking. The Mind your Mate program consists of a 40-minute web-based classroom lesson and a companion smartphone mobile app. The active control group received school-based health education as usual.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A cluster randomized controlled trial was conducted with 12 secondary schools and 166 students (mean age 15.3, SD 0.41 years; 72\/166, 43.4% female; and 133\/166, 80.1% born in Australia). Participants completed self-reported questionnaires assessing symptoms of mental health (depression, anxiety, and psychological distress), substance use (alcohol and other drug use), and help-seeking measures at baseline and at 6-month and 12-month follow-ups.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Students who received the Mind your Mate program had greater reductions in depressive symptoms over a 12-month period than controls (b=\u22121.86, 95% CI \u22123.73 to 0.02; Cohen d=\u22120.31). Anxiety symptoms decreased among students in the intervention group; however, these reductions did not meet statistical significance thresholds. No differences were observed in relation to psychological distress or help-seeking.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Small to moderate reductions in depression symptoms were observed among students allocated to receive the Mind your Mate intervention. Although the current results are encouraging, there is a need to continue to refine, develop, and evaluate innovative applied approaches for the prevention of mental disorders in real-world settings.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n Australian New Zealand Clinical Trials Registry (ANZCTR) ACTRN12620000753954; https:\/\/anzctr.org.au\/Trial\/Registration\/TrialReview.aspx?ACTRN=12620000753954<\/jats:p>\n <\/jats:sec>\n \n International Registered Report Identifier (IRRID)<\/jats:title>\n RR2-10.2196\/26796<\/jats:p>\n <\/jats:sec>","DOI":"10.2196\/45216","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T10:05:36Z","timestamp":1689847536000},"page":"e45216","source":"Crossref","is-referenced-by-count":28,"title":["Evaluating a Peer-Support Mobile App for Mental Health and Substance Use Among Adolescents Over 12 Months During the COVID-19 Pandemic: Randomized Controlled 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