{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:46:02Z","timestamp":1787024762301,"version":"build-2736575974"},"reference-count":32,"publisher":"JMIR Publications Inc.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMIR Public Health Surveill"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>As the life expectancy of individuals infected with HIV continues to increase, vigilant monitoring of non\u2013AIDS-related events becomes imperative, particularly those pertaining to liver diseases. In comparison to the general population, patients infected with HIV experience a higher frequency of liver-related deaths. The CD4\/CD8 ratio is emerging as a potential biomarker for non\u2013AIDS-related events. However, few existing studies have been specially designed to explore the relationship between the CD4\/CD8 ratio and specific types of non\u2013AIDS-related events, notably liver damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to investigate the potential association between the CD4\/CD8 ratio and the development of liver damage in a sizable cohort of patients infected with HIV receiving antiretroviral treatment (ART). Additionally, the study sought to assess the effectiveness of 3 antiretroviral drugs in recovering the CD4\/CD8 ratio and reducing the occurrence of liver damage in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted an observational cohort study among adults infected with HIV receiving ART from 2004 to 2020 in Guangxi, China. Propensity score matching, multivariable Cox proportional hazard, and Fine-Gray competing risk regression models were used to determine the relationship between the CD4\/CD8 ratio recovered and liver damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The incidence of liver damage was 20.12% among 2440 eligible individuals during a median follow-up period of 4 person-years. Patients whose CD4\/CD8 ratio did not recover to 1.0 exhibited a higher incidence of liver damage compared to patients with a CD4\/CD8 ratio recovered (adjusted hazard ratio 7.90, 95% CI 4.39-14.21; P&lt;.001; subdistribution hazard ratio 6.80, 95% CI 3.83-12.11; P&lt;.001), findings consistent with the propensity score matching analysis (adjusted hazard ratio 6.94, 95% CI 3.41-14.12; P&lt;.001; subdistribution hazard ratio 5.67, 95% CI 2.74-11.73; P&lt;.001). The Efavirenz-based regimen exhibited the shortest time for CD4\/CD8 ratio recovery (median 71, IQR 49-88 months) and demonstrated a lower prevalence of liver damage (4.18\/100 person-years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Recovery of the CD4\/CD8 ratio was associated with a decreased risk of liver damage in patients infected with HIV receiving ART, adding evidence for considering the CD4\/CD8 ratio as a potential marker for identifying individuals at risk of non\u2013AIDS-related diseases. An efavirenz-based regimen emerged as a recommended choice for recovering the CD4\/CD8 ratio and mitigating the risk of liver damage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2196\/45818","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:07:06Z","timestamp":1697501226000},"page":"e45818","source":"Crossref","is-referenced-by-count":3,"title":["CD4\/CD8 Ratio Recovered as a Predictor of Decreased Liver Damage in Adults Infected With HIV: 16-Year Observational Cohort 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