{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:08:57Z","timestamp":1789690137954,"version":"4.0.1"},"reference-count":46,"publisher":"JMIR Publications Inc.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMIR Diabetes"],"abstract":"\n Background<\/jats:title>\n Digital weight management interventions (DWMIs) have the potential to support existing specialist weight management services (SWMS) in the National Health Service (NHS) to increase access to treatment for people living with obesity and type 2 diabetes. At present, there is limited real-world evidence and long-term outcomes on the potential effectiveness of DWMIs to support such services.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n This study aimed to examine real-world data to evaluate the impact of Second Nature\u2019s 12-month DWMI for patients living with obesity with or without type 2 diabetes, referred from NHS primary care services, on sustained weight loss over a 2-year period.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Retrospective data were extracted in August 2023 for participants who participated in the program between January 1, 2017, and January 8, 2021. Eligible participants were adults with a BMI \u226535 kg\/m2, with or without type 2 diabetes. The primary outcomes were weight change in kilograms and percentage weight change at 2 years. Secondary outcomes were weight loss at 1 year, program engagement, and the proportion of participants who achieved >5% and >10% weight loss. Differences in weight loss between baseline and the 1- and 2-year follow-up points were compared using paired 2-tailed t tests. Linear regression models were used to examine whether participants\u2019 ethnicity, indices of multiple deprivation, presence of type 2 diabetes, or program engagement were associated with weight loss at 1 year or 2 years.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n A total of 1130 participants with a mean baseline BMI of 46.3 (SD 31.6) kg\/m2 were included in the analysis. Of these participants, 65% (740\/1130) were female (mean age 49.9, SD 12.0 years), 18.1% (205\/339) were from Black, Asian, mixed, or other ethnicities, and 78.2% (884\/1130) had type 2 diabetes. A total of 281 (24.9%) participants recorded weight readings at 2 years from baseline, with a mean weight loss of 13.8 kg (SD 14.2 kg; P<.001) or 11.8% (SD 10.9%; P<.001). A total of 204 (18.1%) participants achieved \u22655% weight loss, and 130 (11.5%) participants reached \u226510% weight loss. Weight loss did not significantly differ by ethnicity, indices of multiple deprivation, presence of type 2 diabetes, or engagement in the program.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The findings suggested that Second Nature\u2019s DWMI has the potential to support people living with obesity and type 2 diabetes remotely to achieve clinically significant and sustained weight loss at 2 years from baseline. Further research is needed to compare the intervention to standard care and assess integration with multidisciplinary clinical teams and pharmacotherapy in order to support this study\u2019s findings.<\/jats:p>\n <\/jats:sec>","DOI":"10.2196\/52987","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T22:48:38Z","timestamp":1702507718000},"page":"e52987","source":"Crossref","is-referenced-by-count":14,"title":["The Potential of a Digital Weight Management Program to Support Specialist Weight Management Services in the UK National Health Service: Retrospective Analysis"],"prefix":"10.2196","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7122-6822","authenticated-orcid":false,"given":"Rebecca","family":"Richards","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9262-7043","authenticated-orcid":false,"given":"Gina","family":"Wren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7144-7545","authenticated-orcid":false,"given":"Michael","family":"Whitman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1010","published-online":{"date-parts":[[2024,1,24]]},"reference":[{"key":"ref1","unstructured":"Health Survey for England, 2021NHS Digital20232023-09-23https:\/\/digital.nhs.uk\/data-and-information\/publications\/statistical\/health-survey-for-england?"},{"key":"ref2","unstructured":"National Survey for Wales headline results: April 2021 to March 2022Welsh Government20222023-12-19https:\/\/www.gov.wales\/national-survey-wales-headline-results-april-2021-march-2022-html#:~:text=36%25"},{"key":"ref3","unstructured":"Obesity in Scotland: prevalence, causes and impactObesity Action Scotland20232023-12-19https:\/\/www.obesityactionscotland.org\/media\/locdychb\/obesity_prevalence_causes__impact_202122_data_f.pdf"},{"key":"ref4","unstructured":"Health Survey Northern Ireland 2019\/20: first resultsDepartment of Health20232023-12-19https:\/\/www.gov.uk\/government\/statistics\/health-survey-northern-ireland-201920-first-results"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.191707"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60318-4"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2010.04.012"},{"key":"ref8","unstructured":"Estimating the full costs of obesityFrontier Economics20222023-12-19https:\/\/www.frontier-economics.com\/media\/hgwd4e4a\/the-full-cost-of-obesity-in-the-uk.pdf"},{"key":"ref9","unstructured":"Clinical commissioning policy: complex and specialised obesity surgeryNHS Commissioning Board20132023-12-19https:\/\/www.england.nhs.uk\/wp-content\/uploads\/2016\/05\/appndx-6-policy-sev-comp-obesity-pdf.pdf"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/edm2.42"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s13679-020-00416-8"},{"key":"ref12","first-page":"37","author":"Coulton, V","year":"2015","journal-title":"Public Health England"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s40271-023-00644-9"},{"key":"ref14","unstructured":"New drugs pilot to tackle obesity and cut NHS waiting listsUK Government20232023-12-19https:\/\/www.gov.uk\/government\/news\/new-drugs-pilot-to-tackle-obesity-and-cut-nhs-waiting-lists"},{"key":"ref15","unstructured":"Semaglutide for managing overweight and obesityNational Institute for Health and Care Excellence20232023-12-19https:\/\/www.nice.org.uk\/guidance\/ta875"},{"key":"ref16","unstructured":"Digital technologies for delivering specialist weight-management services to manage weight-management medicine: early value assessmentNational Institute for Health and Care 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Public health guideline [PH49]National Institute for Health and Care Excellence20142023-12-19https:\/\/www.nice.org.uk\/guidance\/ph49"},{"key":"ref37","unstructured":"Obesity: working with local communities. Public health guideline [PH42]National Institute for Health and Care Excellence20172023-12-19https:\/\/www.nice.org.uk\/guidance\/ph42"},{"key":"ref38","unstructured":"NHS Diabetes prevention programme: an opportunity to partner with the behavioural insight team to improve outcomesPublic Health England and NHS England Behavioural Insights Team20162023-12-19https:\/\/www.england.nhs.uk\/wp-content\/uploads\/2016\/07\/behav-insight.pdf"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1186\/1748-5908-6-42"},{"key":"ref40","unstructured":"English indices of deprivation 2019Ministry of Housing, Communities & Local Government20192023-12-19https:\/\/www.gov.uk\/government\/statistics\/english-indices-of-deprivation-2019"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2013.180"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.2196\/jmir.5473"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1002\/pdi.2295"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.2196\/41256"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13438"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13542"}],"container-title":["JMIR Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetes.jmir.org\/2024\/1\/e52987","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T17:38:13Z","timestamp":1782841093000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetes.jmir.org\/2024\/1\/e52987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,24]]},"references-count":46,"URL":"https:\/\/doi.org\/10.2196\/52987","relation":{"has-preprint":[{"id-type":"doi","id":"10.2196\/preprints.52987","asserted-by":"object"}]},"ISSN":["2371-4379"],"issn-type":[{"value":"2371-4379","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,24]]}}}