{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:32:41Z","timestamp":1787506361613,"version":"build-2736575974"},"reference-count":26,"publisher":"JMIR Publications Inc.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMIR Form Res"],"abstract":"\n Background<\/jats:title>\n Smoking contributes to 1 in 3 cancer deaths. At the Stanford Cancer Center, tobacco cessation medication management and counseling are provided as a covered benefit. Patients charted as using tobacco are contacted by a tobacco treatment specialist and offered cessation services. As a novel addition, this study examined the acceptability of a virtual reality (VR) mindful exposure therapy app for quitting smoking called MindCotine.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n The objective of this study was to determine the feasibility and acceptability of offering 6 weeks of MindCotine treatment as a part of Stanford\u2019s Tobacco Treatment Services for patients seen for cancer care.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n As part of a single-group pilot study, the MindCotine VR program was offered to English- or Spanish-speaking patients interested in quitting smoking. Given the visual interface, epilepsy was a medical exclusion. Viewed from a smartphone with an attachable VR headset, MindCotine provides a digital environment with audiovisual content guiding mindfulness exercises (eg, breathing techniques, body awareness, and thought recognition), text-based coaching, and cognitive behavioral therapy-based self-reflections for quitting smoking. Interested patients providing informed consent were mailed a MindCotine headset and asked to use the app for 10+ minutes a day. At the end of 6 weeks, participants completed a feedback survey.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Of the 357 patients reached by the tobacco treatment specialist, 62 (17.3%) were ineligible, 190 (53.2%) were not interested in tobacco treatment services, and 78 (21.8%) preferred other tobacco treatment services. Among the 105 eligible and interested in assistance with quitting, 27 (25.7%) were interested in MindCotine, of whom 20 completed the informed consent, 9 used the program, and 8 completed their end-of-treatment survey. Participants using MindCotine completed, on average, 13 (SD 20.2) program activities, 19 (SD 26) journal records, and 11 (SD 12.3) coaching engagements. Of the 9 participants who used MindCotine, 4 (44%) reported some dizziness with app use that resolved and 7 (78%) would recommend MindCotine to a friend. In total, 2 participants quit tobacco (22.2% reporting, 10% overall), 2 others reduced their smoking by 50% or more, and 2 quit for 24 hours and then relapsed.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n In a feasibility and acceptability pilot study of a novel VR tobacco treatment app offered to patients at a cancer center, 4 of 9 (44%) reporting and 4 of 20 (20%) overall substantially reduced or quit using tobacco after 6 weeks and most would recommend the app to others. Further testing on a larger sample is warranted.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n ClinicalTrials.gov NCT05220254; https:\/\/clinicaltrials.gov\/study\/NCT05220254<\/jats:p>\n <\/jats:sec>","DOI":"10.2196\/54817","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T03:16:01Z","timestamp":1716952561000},"page":"e54817","source":"Crossref","is-referenced-by-count":4,"title":["Adding Virtual Reality Mindful Exposure Therapy to a Cancer Center\u2019s Tobacco Treatment Offerings: Feasibility and Acceptability Single-Group Pilot Study"],"prefix":"10.2196","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9859-1665","authenticated-orcid":false,"given":"Riley Walton","family":"Jackson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1816-8973","authenticated-orcid":false,"given":"Ann","family":"Cao-Nasalga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2739-7338","authenticated-orcid":false,"given":"Amy","family":"Chieng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4036-9625","authenticated-orcid":false,"given":"Amy","family":"Pirkl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8893-507X","authenticated-orcid":false,"given":"Annemarie D","family":"Jagielo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0286-772X","authenticated-orcid":false,"given":"Cindy","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9672-7578","authenticated-orcid":false,"given":"Emilio","family":"Goldenhersch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2100-4070","authenticated-orcid":false,"given":"Nicolas","family":"Rosencovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9996-1140","authenticated-orcid":false,"given":"Cristian","family":"Waitman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7925-326X","authenticated-orcid":false,"given":"Judith J","family":"Prochaska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1010","published-online":{"date-parts":[[2024,7,23]]},"reference":[{"key":"ref1","unstructured":"Smoking cessation: a report of the surgeon general (executive summary)U.S. Department of Health and Human Services20202024-06-07https:\/\/www.hhs.gov\/sites\/default\/files\/2020-cessation-sgr-executive-summary.pdf"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aay9763"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17062101"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.15585\/mmwr.mm6552a1","volume":"65","author":"Babb, S","year":"2017","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"45","key":"ref5","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.15585\/mmwr.mm6845a2","volume":"68","author":"Creamer, MR","year":"2019","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.drugalcdep.2013.03.008","volume":"132","author":"Garc\u00eda-Rodr\u00edguez, O","year":"2013","journal-title":"Drug Alcohol Depend"},{"key":"ref7","unstructured":"CorelliRLHudmonKSIntegrating medications into smoking cessation treatment: the basicsUCSF Smoking Cessation Leadership Center2022-02-01https:\/\/ucsf.app.box.com\/s\/iagrat06fq4bvwrafufidtvewutnkwvb"},{"key":"ref8","unstructured":"MorrisCDSripipatanaAA team approach: integrating tobacco dependence treatment into routine clinical practiceUCSF Smoking Cessation Leadership Center2022-02-23https:\/\/smokingcessationleadership.ucsf.edu\/webinar\/team-approach-integrating-tobacco-dependence-treatment-routine-clinical-practice"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"470","DOI":"10.4101\/jvwr.v2i2.470","volume":"2","author":"Krebs, P","year":"2009","journal-title":"J Virtual Worlds Res"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-011-1673-0"},{"key":"ref11","unstructured":"Office of the CommissionerWant to Quit Smoking? 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