{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T18:03:36Z","timestamp":1782842616269,"version":"3.54.5"},"reference-count":38,"publisher":"JMIR Publications Inc.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMIR Med Educ"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec sec-type=\"background\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Emergency obstetric simulation-based training has increasingly been used to improve emergency obstetric care provision in sub-Saharan Africa. For determining the optimal methodology for effective training sessions in resource-constrained settings, it is crucial to conduct high-quality research.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"objective\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aim to investigate the impact of a train-the-trainer model for providing technology-enhanced, mono-professional, simulation-based training in obstetrics in a resource-constrained setting on maternal and perinatal outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A stepped-wedge cluster randomized trial was conducted from October 2014 until March 2016 at the medium- to high-risk ward at Mulago National Referral Hospital, Uganda, with an annual delivery rate of over 23,000. The intervention consisted of a train-the-trainer model in which training was cascaded down from master trainers to local facilitators (obstetric senior staff members) to learners (senior house officers). The training of senior house officers was provided to 7 fixed clusters by a computer-generated random sequential roll-out. The training comprised a 1-day (8 h), mono-professional, simulation-based training in obstetrics, and half-day repetition training sessions targeted at every 7 weeks. Both medical technical skills and teamwork skills were taught. The primary outcome comprised a combined maternal and perinatal mortality rate. Secondary outcomes comprised the maternal mortality rate, the perinatal mortality rate, the percentage of births by vacuum extraction and cesarean section, and the Weighted Adverse Outcome Score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, there were 17,496 births. The combined mortality rate was 9.05% (95% CI 8.37%\u20109.77%) in the intervention group, and 8.73% (95% CI 8.21%\u20109.28%) in the control group (odds ratio [OR] 0.98, 95% CI 0.86\u20101.12;\n                      <jats:italic>P<\/jats:italic>\n                      =.81). No statistically significant change was found in the maternal mortality rate (OR 0.80, 95% CI 0.27\u20102.32;\n                      <jats:italic>P<\/jats:italic>\n                      =.68) or the perinatal mortality rate (OR 0.99, 95% CI 0.87\u20101.13;\n                      <jats:italic>P<\/jats:italic>\n                      =.87). This study did not identify any difference in the percentage of vacuum extractions, the percentage of cesarean sections, or Weighted Adverse Outcome Scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This train-the-trainer model for providing technology-enhanced, mono-professional, simulation-based training in obstetrics was not able to change maternal and perinatal mortality outcomes. This study, in combination with literature, suggests that future research should consider multiprofessional team training in obstetrics involving all staff within their units.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2196\/54911","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T14:33:08Z","timestamp":1746801188000},"page":"e54911-e54911","source":"Crossref","is-referenced-by-count":0,"title":["Mono-Professional Simulation-Based Obstetric Training in a Low-Resource Setting: Stepped-Wedge Cluster Randomized Trial"],"prefix":"10.2196","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2185-872X","authenticated-orcid":false,"given":"Anne A C","family":"van Tetering","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2791-4577","authenticated-orcid":false,"given":"Ella L","family":"de Vries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5343-0392","authenticated-orcid":false,"given":"Peter","family":"Ntuyo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9157-7224","authenticated-orcid":false,"given":"E R","family":"van den Heuvel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9391-5397","authenticated-orcid":false,"given":"Annemarie F","family":"Fransen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5805-5333","authenticated-orcid":false,"given":"M Beatrijs","family":"van der Hout-van der Jagt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9874-7302","authenticated-orcid":false,"given":"Imelda","family":"Namagembe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3438-9662","authenticated-orcid":false,"given":"Josaphat","family":"Byamugisha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0157-3332","authenticated-orcid":false,"given":"S Guid","family":"Oei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1010","published-online":{"date-parts":[[2025,5,9]]},"reference":[{"key":"R1","unstructured":"WHO, UNICEF, UNFPA, World Bank Group and the UN. Trends in maternal mortality: 2000 to 2017. World Bank Group. 2019. URL: https:\/\/data.worldbank.org\/indicator\/SH.STA.MMRT?locations=UG [Accessed 16-04-2025]"},{"issue":"1","key":"R2","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-018-0720-y","article-title":"Barriers to access and utilization of emergency obstetric care at health facilities in sub-Saharan Africa-a systematic review protocol","volume":"7","author":"Geleto","journal-title":"Syst Rev"},{"issue":"8","key":"R3","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1016\/j.bpobgyn.2015.03.017","article-title":"What is the impact of multi-professional emergency obstetric and neonatal care training?","volume":"29","author":"Bergh","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"4","key":"R4","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1093\/heapol\/czz028","article-title":"The effectiveness of training in emergency obstetric care: a systematic literature review","volume":"34","author":"Ameh","journal-title":"Health Policy Plan"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2022.07.003","article-title":"Simulation training for obstetric emergencies in low- and lower-middle income countries: a systematic review","volume":"276","author":"Chou","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"2","key":"R6","doi-asserted-by":"publisher","first-page":"e353","DOI":"10.1542\/peds.2012-1795","article-title":"Newborn mortality and fresh stillbirth rates in Tanzania after helping babies breathe training","volume":"131","author":"Msemo","journal-title":"Pediatrics"},{"issue":"10","key":"R7","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1016\/j.ijnurstu.2011.03.001","article-title":"Evaluation of simulation-based training on the ability of birth attendants to correctly perform bimanual compression as obstetric first aid","volume":"48","author":"Andreatta","journal-title":"Int J Nurs Stud"},{"issue":"9887","key":"R8","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/S0140-6736(13)60593-0","article-title":"Quality of care, risk management, and technology in obstetrics to reduce hospital-based maternal mortality in Senegal and Mali (QUARITE): a cluster-randomised trial","volume":"382","author":"Dumont","journal-title":"Lancet"},{"issue":"6","key":"R9","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1111\/j.1600-0412.2011.01115.x","article-title":"Advanced life support in obstetrics (ALSO) and post-partum hemorrhage: a prospective intervention study in Tanzania","volume":"90","author":"Sorensen","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"1","key":"R10","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-020-03050-3","article-title":"Study protocol training for life: a stepped wedge cluster randomized trial about emergency obstetric simulation-based training in a low-income country","volume":"20","author":"van Tetering","journal-title":"BMC Pregnancy Childbirth"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-6-54","article-title":"The stepped wedge trial design: a systematic review","volume":"6","author":"Brown","journal-title":"BMC Med Res Methodol"},{"issue":"1","key":"R12","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1097\/01.AOG.0000250900.53126.c2","article-title":"Effects of teamwork training on adverse outcomes and process of care in labor and delivery: a randomized controlled trial","volume":"109","author":"Nielsen","journal-title":"Obstet Gynecol"},{"issue":"1","key":"R13","doi-asserted-by":"publisher","DOI":"10.2196\/17277","article-title":"Evaluating the instructional design and effect on knowledge, teamwork, and skills of technology-enhanced simulation-based training in obstetrics in Uganda: stepped-wedge cluster randomized trial","volume":"7","author":"van Tetering","journal-title":"JMIR Med Educ"},{"issue":"2","key":"R14","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.cct.2006.05.007","article-title":"Design and analysis of stepped wedge cluster randomized trials","volume":"28","author":"Hussey","journal-title":"Contemp Clin Trials"},{"issue":"7","key":"R15","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1016\/j.jclinepi.2013.01.009","article-title":"Stepped wedge designs could reduce the required sample size in cluster randomized trials","volume":"66","author":"Woertman","journal-title":"J Clin Epidemiol"},{"issue":"12","key":"R16","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1016\/j.jclinepi.2013.07.008","article-title":"The stepped wedge cluster randomized trial always requires fewer clusters but not always fewer measurements, that is, participants than a parallel cluster randomized trial in a cross-sectional design","volume":"66","author":"de Hoop","journal-title":"J Clin Epidemiol"},{"issue":"SUPPL. 5","key":"R17","volume":"131","author":"Chong","journal-title":"Int J Gynecol Obstet 21st FIGO World Congr Gynecol Obstet BC CanadaConference Publ"},{"issue":"3","key":"R18","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1097\/SIH.0b013e318291d9ef","article-title":"It is time to consider cultural differences in debriefing","volume":"8","author":"Chung","journal-title":"Simul Healthc"},{"issue":"11","key":"R19","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1111\/j.1365-2923.2012.04343.x","article-title":"Non-technical skills training to enhance patient safety: a systematic review","volume":"46","author":"Gordon","journal-title":"Med Educ"},{"issue":"Suppl 2","key":"R20","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1186\/s13063-019-3842-1","article-title":"Ethical issues in the design and conduct of stepped-wedge cluster randomized trials in low-resource settings","volume":"20","author":"Joag","journal-title":"Trials"},{"issue":"1","key":"R21","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1186\/s13063-015-0837-4","article-title":"Logistic, ethical, and political dimensions of stepped wedge trials: critical review and case studies","volume":"16","author":"Prost","journal-title":"Trials"},{"issue":"4","key":"R22","doi-asserted-by":"publisher","first-page":"241","DOI":"10.7196\/SAMJ.2019.v109i4.13578","article-title":"Reducing maternal deaths by skills-and-drills training in managing obstetric emergencies: a before-and-after observational study","volume":"109","author":"Pattinson","journal-title":"S Afr Med J"},{"issue":"1","key":"R23","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-017-1481-7","article-title":"Clinical performance and patient outcome after simulation-based training in prevention and management of postpartum haemorrhage: an educational intervention study in a low-resource setting","volume":"17","author":"Nelissen","journal-title":"BMC Pregnancy Childbirth"},{"issue":"3","key":"R24","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1002\/ijgo.13395","article-title":"Effects of the helping mothers survive bleeding after birth training on near miss morbidity and mortality in Uganda: a cluster-randomized trial","volume":"152","author":"Hanson","journal-title":"Int J Gynaecol Obstet"},{"issue":"12","key":"R25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0207909","article-title":"Peer-assisted learning after onsite, low-dose, high-frequency training and practice on simulators to prevent and treat postpartum hemorrhage and neonatal asphyxia: a pragmatic trial in 12 districts in Uganda","volume":"13","author":"Evans","journal-title":"PLoS ONE"},{"issue":"3","key":"R26","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1097\/AOG.0000000000003108","article-title":"Implementation of the Alliance for Innovation on Maternal Health Program to reduce maternal mortality in Malawi","volume":"133","author":"Chang","journal-title":"Obstet Gynecol"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2014.12.023","article-title":"Effect of maternal death reviews and training on maternal mortality among cesarean delivery: post-hoc analysis of a cluster-randomized controlled trial","volume":"185","author":"Zongo","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"8","key":"R28","doi-asserted-by":"publisher","first-page":"e1061","DOI":"10.1016\/S2214-109X(20)30232-1","article-title":"Effect of a quality improvement package for intrapartum and immediate newborn care on fresh stillbirth and neonatal mortality among preterm and low-birthweight babies in Kenya and Uganda: a cluster-randomised facility-based trial","volume":"8","author":"Walker","journal-title":"Lancet Glob Health"},{"issue":"10","key":"R29","doi-asserted-by":"publisher","first-page":"1666","DOI":"10.1111\/apa.13940","article-title":"Using quality improvement to decrease birth asphyxia rates after \u201cHelping Babies Breathe\u201d training in Kenya","volume":"106","author":"Rule","journal-title":"Acta Paediatr"},{"issue":"4","key":"R30","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1093\/intqhc\/mzy003","article-title":"Using statistical process control methods to trace small changes in perinatal mortality after a training program in a low-resource setting","volume":"30","author":"Mduma","journal-title":"Int J Qual Health Care"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2015.04.019","article-title":"Frequent brief on-site simulation training and reduction in 24-h neonatal mortality--an educational intervention study","volume":"93","author":"Mduma","journal-title":"Resuscitation"},{"issue":"1","key":"R32","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-018-1705-5","article-title":"Accelerating newborn survival in Ghana through a low-dose, high-frequency health worker training approach: a cluster randomized trial","volume":"18","author":"Gomez","journal-title":"BMC Pregnancy Childbirth"},{"issue":"1","key":"R33","doi-asserted-by":"publisher","DOI":"10.1080\/16549716.2017.1387985","article-title":"Retention and use of newborn resuscitation skills following a series of helping babies breathe trainings for midwives in rural Ghana","volume":"10","author":"Eblovi","journal-title":"Glob Health Action"},{"issue":"8","key":"R34","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1111\/j.1471-0528.2009.02178.x","article-title":"The active components of effective training in obstetric emergencies","volume":"116","author":"Siassakos","journal-title":"BJOG An Int J Obstet Gynaecol"},{"issue":"10","key":"R35","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-008344","article-title":"Simulation-based multiprofessional obstetric anaesthesia training conducted in situ versus off-site leads to similar individual and team outcomes: a randomised educational trial","volume":"5","author":"S\u00f8rensen","journal-title":"BMJ Open"},{"issue":"12","key":"R36","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011545.pub2","article-title":"Multi-professional simulation-based team training in obstetric emergencies for improving patient outcomes and trainees\u2019 performance","volume":"12","author":"Fransen","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"R37","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1111\/1471-0528.14369","article-title":"Simulation-based team training for multi-professional obstetric care teams to improve patient outcome: a multicentre, cluster randomised controlled trial","volume":"124","author":"Fransen","journal-title":"BJOG An Int J Obstet Gynaecol"},{"issue":"2","key":"R38","doi-asserted-by":"publisher","first-page":"146","DOI":"10.2471\/BLT.13.124347","article-title":"Adaptation and implementation of local maternity dashboards in a Zimbabwean hospital to drive clinical improvement","volume":"92","author":"Crofts","journal-title":"Bull World Health Organ"}],"container-title":["JMIR Medical Education"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/mededu.jmir.org\/2025\/1\/e54911","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T17:42:09Z","timestamp":1782841329000},"score":1,"resource":{"primary":{"URL":"https:\/\/mededu.jmir.org\/2025\/1\/e54911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,9]]},"references-count":38,"URL":"https:\/\/doi.org\/10.2196\/54911","relation":{},"ISSN":["2369-3762"],"issn-type":[{"value":"2369-3762","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,9]]},"article-number":"v11i1e54911"}}