{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:32:25Z","timestamp":1792056745738,"version":"4.4.0"},"reference-count":95,"publisher":"JMIR Publications Inc.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMIR Cancer"],"abstract":"\n Background<\/jats:title>\n Black\/African American adults are underrepresented in oncology clinical trials in the United States, despite efforts at narrowing this disparity.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n This study aims to explore differences in how Black\/African American oncology patients perceive clinical trials to improve support for the clinical trial participation decision-making process.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n As part of a larger randomized controlled trial, a total of 244 adult oncology patients receiving active treatment or follow-up care completed a cross-sectional baseline survey on sociodemographic characteristics, clinical trial knowledge, health literacy, perceptions of cancer clinical trials, patient activation, patient advocacy, health care self-efficacy, decisional conflict, and clinical trial intentions. Self-reported race was dichotomized into Black\/African American and non\u2013Black\/African American. As appropriate, 2-tailed t tests and chi-square tests of independence were used to examine differences between groups.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Black\/African American participants had lower clinical trial knowledge (P=.006), lower health literacy (P<.001), and more medical mistrust (all P values <.05) than non\u2013Black\/African American participants. While intentions to participate in a clinical trial, if offered, did not vary between Black\/African American and non\u2013Black\/African American participants, Black\/African American participants indicated lower awareness of clinical trials, fewer benefits of clinical trials, and more uncertainty around clinical trial decision-making (all P values <.05). There were no differences for other variables.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Despite no significant differences in intent to participate in a clinical trial if offered and high overall trust in individual health care providers among both groups, beliefs persist about barriers to and benefits of clinical trial participation among Black\/African American patients. Findings highlight specific ways that education and resources about clinical trials could be tailored to better suit the informational and decision-making needs and preferences of Black\/African American oncology patients.<\/jats:p>\n <\/jats:sec>","DOI":"10.2196\/56048","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T17:01:47Z","timestamp":1727715707000},"page":"e56048","source":"Crossref","is-referenced-by-count":8,"title":["Exploring Racial Disparities in Awareness and Perceptions of Oncology Clinical Trials: Cross-Sectional Analysis of Baseline Data From the mychoice 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