{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:09:34Z","timestamp":1790510974327,"version":"4.1.0"},"reference-count":37,"publisher":"JMIR Publications Inc.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMIR Infodemiology"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>As we move beyond the COVID-19 pandemic, the risk of future infodemics remains significant, driven by emerging health crises and the increasing influence of artificial intelligence in the information ecosystem. During periods of apparent stability, proactive efforts to advance infodemiology are essential for enhancing preparedness and improving public health outcomes. This requires a thorough examination of the foundations of this evolving discipline, particularly in understanding how to accurately identify an infodemic at the appropriate time and scale, and how to distinguish it from other processes of viral information spread, both within and outside the realm of public health. In this paper, we integrate expertise from data science and public health to examine the key differences between information production during an infodemic and viral information spread. We explore both clear and subtle distinctions, including context and contingency (ie, the association of an infodemic and viral information spread with a health crisis); information dynamics in terms of volume, spread, and predictability; the role of misinformation and information voids; societal impact; and mitigation strategies. By analyzing these differences, we highlight challenges and open questions. These include whether an infodemic is solely associated with pandemics or whether it could arise from other health emergencies; if infodemics are limited to health-related issues or if they could emerge from crises initially unrelated to health (like climate events); and whether infodemics are exclusively global phenomena or if they can occur on national or local scales. Finally, we propose directions for future quantitative research to help the scientific community more robustly differentiate between these phenomena and develop tailored management strategies.<\/jats:p>","DOI":"10.2196\/57455","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T17:50:51Z","timestamp":1746640251000},"page":"e57455-e57455","source":"Crossref","is-referenced-by-count":6,"title":["Infodemic Versus Viral Information Spread: Key Differences and Open Challenges"],"prefix":"10.2196","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3899-4592","authenticated-orcid":false,"given":"Matteo","family":"Cinelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9087-4398","authenticated-orcid":false,"given":"Francesco","family":"Gesualdo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1010","published-online":{"date-parts":[[2025,5,7]]},"reference":[{"key":"R1","unstructured":"Rothkopf DJ . 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