{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:45:49Z","timestamp":1785545149405,"version":"3.56.0"},"reference-count":47,"publisher":"JMIR Publications Inc.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMIR Form Res"],"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Insulin resistance and the G allele of rs738409 interact to create a greater risk of metabolic dysfunction\u2013associated steatotic liver disease.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n This study aims to confirm that one promising way to reduce insulin resistance is by following a very low\u2013carbohydrate (VLC) dietary pattern.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Adults with rs738409-GG or -CG with liver steatosis and elevated liver function tests, were taught an ad libitum VLC diet, positive affect and mindful eating skills, goal setting, and self-monitoring and given feedback and coaching for 4 months. We measured liver steatosis, anthropometric, serum metabolic diet adherence, and quality of life measures.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n In this small pilot trial, of the 11 participants enrolled, 9 (82%) participants completed outcomes. All 11 participants viewed at least 1 session of the intervention, and 8 (73%) participants viewed at least half of the sessions. Among the 9 participants who provided 4-month self-report information, intervention satisfaction was high (mean 6.22, 95% CI 5.58-6.85), with 5 (56%) participants rating the intervention the top score, and 4 (44%) participants reporting they did not plan to stop following the VLC diet. Across participants with a 4-month hepatic liver fat percent measurement, the percent change in liver fat was \u221233.17% (95% CI \u221286.48 to 20.14), and in only the participants who were adherent to the eating pattern, the percent change in liver fat was \u221253.12% (95% CI \u221271.25 to \u221234.99). Amongst participants with a 4-month hepatic liver fat percent measurement, 6 out of 8 (75%) participants were considered responders, with a relative decline in liver fat \u226530%, and of the 9 participants with a 4-month body weight, 9 (100%) participants lost \u22655% of their body weight. There were no serious adverse events.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Results suggest the feasibility, acceptability, and preliminary efficacy of the VLC intervention in adults with higher genetic risk for metabolic dysfunction\u2013associated steatotic liver disease, although there is a need for further studies given the small sample size and the high risk of substantial biases in this small pilot study.<\/jats:p>\n <\/jats:sec>","DOI":"10.2196\/60051","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T02:08:22Z","timestamp":1736734102000},"page":"e60051-e60051","source":"Crossref","is-referenced-by-count":3,"title":["A Very Low\u2013Carbohydrate Program in Adults With Metabolic Dysfunction\u2013Associated Steatotic Liver Disease and Phospholipase Domain\u2013Containing Protein 3 Risk Genotype: Pre-Post Intervention 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