{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:52:21Z","timestamp":1785891141782,"version":"3.56.0"},"reference-count":75,"publisher":"JMIR Publications Inc.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMIR Mhealth Uhealth"],"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Anxiety and mood disorders, characterized by elevated negative affect (NA) and cognitive impairments, are highly prevalent among college students. Within-person (WP) NA variability, which captures moment-to-moment fluctuations in NA, provides unique insights into emotional processes that are not reflected in mean NA levels. Cognitive variability, particularly reaction time (RT) inconsistency, is increasingly recognized as a sensitive marker of cognitive health and functional integrity. Although prior research links NA to cognitive variability, the short-term dynamics of these associations in naturalistic settings remain understudied. College students provide an ideal population for examining these dynamics using ecological momentary assessment (EMA).<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n This study investigated the association between WP NA and RT inconsistency, hypothesizing that higher WP fluctuations in NA would predict increased RT inconsistency. We also examined the moderating roles of practice effects and covariates, including neuroticism, insomnia, and sex.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Using EMA, 99 university students completed morning and evening assessments over 14 days, including a cognitive task measuring RT inconsistency (standard deviation in trial-level RT) and self-reported NA. Multilevel modeling was used to assess WP fluctuations in NA and their impact on RT inconsistency, accounting for time (session number), between-person differences in NA, and covariates such as sleep problems, neuroticism, age, sex, and use of a touch device.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n WP fluctuations in NA significantly predicted increased RT inconsistency (exp(\u03b2)=1.022, 95% CI 1.008\u20101.037;\n P<\/jats:italic>\n =.007), supporting the hypothesis that NA variability disrupts cognitive performance. Male students exhibited lower RT inconsistency than female students, with a small effect size (exp(\u03b2)=0.824, 95% CI 0.694\u20100.977;\n P<\/jats:italic>\n =.049). Finally, EMA sessions were inversely associated with RT inconsistency, with a stronger effect up to session 3 (exp(\u03b2)=0.930, 95% CI 0.879\u20100.985;\n P<\/jats:italic>\n =.03) than after session 3 (exp(\u03b2)=0.986, 95% CI=0.979\u20100.992;\n P<\/jats:italic>\n <.001), indicating practice effects.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Momentary fluctuations in NA influence cognitive variability, particularly in the early stages of repeated cognitive tasks, underscoring the role of emotional processes in cognitive performance. Practice effects and individual differences, such as sex and insomnia, influence these associations. These findings highlight the use of EMA for understanding cognitive-affective processes and suggest potential intervention targets, such as addressing NA, to improve cognitive functioning in emotionally vulnerable populations like college students.<\/jats:p>\n <\/jats:sec>","DOI":"10.2196\/64397","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T18:55:09Z","timestamp":1778525709000},"page":"e64397-e64397","source":"Crossref","is-referenced-by-count":1,"title":["Daily Negative Affect and Reaction Time Inconsistency in Emerging Adults: Ecological Momentary Assessment Study"],"prefix":"10.2196","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8852-7602","authenticated-orcid":false,"given":"Lauren Alexandra","family":"Rutter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5124-5054","authenticated-orcid":false,"given":"Pei-Ying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8126-2429","authenticated-orcid":false,"given":"Prabhvir","family":"Lakhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8690-8412","authenticated-orcid":false,"given":"Laura Thi","family":"Germine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3796-0289","authenticated-orcid":false,"given":"Zoe","family":"Hawks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1010","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"issue":"2","key":"R1","doi-asserted-by":"publisher","first-page":"155","DOI":"10.4088\/JCP.14m09298","article-title":"The economic burden of adults with major depressive disorder in the United States (2005 and 2010)","volume":"76","author":"Greenberg","journal-title":"J Clin Psychiatry"},{"issue":"9859","key":"R2","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1016\/S0140-6736(12)61689-4","article-title":"Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Murray","journal-title":"Lancet"},{"issue":"5","key":"R3","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1177\/1745691614544528","article-title":"The origins of neuroticism","volume":"9","author":"Barlow","journal-title":"Perspect Psychol Sci"},{"issue":"4","key":"R4","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1177\/0031512519848221","article-title":"Associations between neuroticism and executive function outcomes: response inhibition and sustained attention on a continuous performance test","volume":"126","author":"Crow","journal-title":"Percept Mot Skills"},{"issue":"2","key":"R5","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1111\/j.1745-6916.2008.00067.x","article-title":"Affect and cognition","volume":"3","author":"Forgas","journal-title":"Perspect Psychol Sci"},{"issue":"2","key":"R6","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1037\/pspp0000186","article-title":"The bipolarity of affect and depressive symptoms","volume":"114","author":"Dejonckheere","journal-title":"J Pers Soc Psychol"},{"issue":"4","key":"R7","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1037\/a0038822","article-title":"The relation between short-term emotion dynamics and psychological well-being: a meta-analysis","volume":"141","author":"Houben","journal-title":"Psychol Bull"},{"issue":"2","key":"R8","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1037\/emo0000541","article-title":"Everyday emotional dynamics in major depression","volume":"20","author":"Nelson","journal-title":"Emotion"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2020.112932","article-title":"On the nature of objective and perceived cognitive impairments in depressive symptoms and real-world functioning in young adults","volume":"287","author":"Dhillon","journal-title":"Psychiatry Res"},{"key":"R10","doi-asserted-by":"crossref","unstructured":"Waugh CE Kuppens P . 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