{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:32:09Z","timestamp":1790883129208,"version":"4.1.0"},"reference-count":50,"publisher":"JMIR Publications Inc.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMIR Cancer"],"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Online self-management interventions for cancer survivors are increasingly being used, but engagement is often difficult for patients. Given the importance of engagement for intervention effectiveness, identifying patient-reported barriers and facilitators is essential.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n The aim of this study was to qualitatively examine barriers and facilitators influencing engagement with an online self-management intervention, offered with or without guidance, for cancer survivors experiencing chronic painful chemotherapy-induced peripheral neuropathy (CIPN).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Patients who took part in the Embrace Pain randomized controlled trial, conducted between December 2021 and July 2024, were invited to participate in this study. Eligible participants were adults with chronic painful CIPN, based on criteria including pain, completion of chemotherapy, and European Organisation for Research and Treatment of Cancer QLQ-CIPN20 Questionnaire (ie, cancer-specific measure of sensory, motor, and autonomic neuropathy). The Embrace Pain randomized controlled trial involved evaluating an online self-management acceptance and commitment therapy intervention for pain interference in daily life, with some participants receiving email guidance and others not. Thereafter, 12 patients experiencing chronic painful CIPN participated in semistructured interviews. Data were analyzed using thematic analysis. An inductive coding approach was applied, and Atlas.ti (Lumivero) was used for coding.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n In total, 2 themes and 17 codes emerged from the data, namely 7 codes for barriers and 10 codes for facilitators. Barriers included program schedule, burden, lack of guidance, irrelevance, mindfulness exercises, usability, and missing content. Facilitators included usability, recognition, positive self-management, program schedule, symptom management, relevance, guidance, experiential exercises, mindfulness exercises, and value-based living. Program schedule, guidance, mindfulness exercises, and usability proved to be barriers for some, while others indicated that they were facilitators for their use.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Participants\u2019 perceptions of the intervention varied, with engagement influenced by individual circumstances. These variations highlight the importance of personal context in shaping both uptake and effectiveness, indicating a need for tailored approaches to address diverse needs and challenges faced by participants.<\/jats:p>\n <\/jats:sec>","DOI":"10.2196\/64983","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T18:48:29Z","timestamp":1758912509000},"page":"e64983-e64983","source":"Crossref","is-referenced-by-count":2,"title":["Exploring Barriers and Facilitators to Engagement of an Online Acceptance and Commitment Therapy Intervention for Cancer Survivors With Chronic Painful Chemotherapy-Induced Peripheral Neuropathy: Qualitative Interview Study"],"prefix":"10.2196","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6862-0172","authenticated-orcid":false,"given":"Dani\u00eblle","family":"van de Graaf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1316-7008","authenticated-orcid":false,"given":"Marije","family":"van der Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3773-0264","authenticated-orcid":false,"given":"Tom","family":"Smeets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4518-6999","authenticated-orcid":false,"given":"Hester","family":"Trompetter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0818-2913","authenticated-orcid":false,"given":"Floortje","family":"Mols","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1010","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"issue":"4","key":"R1","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/j.jpain.2017.11.009","article-title":"Self-guided online cognitive behavioral strategies for chemotherapy-induced peripheral neuropathy: a multicenter, pilot, randomized, wait-list controlled trial","volume":"19","author":"Knoerl","journal-title":"J Pain"},{"issue":"2","key":"R2","doi-asserted-by":"publisher","DOI":"10.2196\/formative.9954","article-title":"A stress management app intervention for cancer survivors: design, development, and usability testing","volume":"2","author":"B\u00f8r\u00f8sund","journal-title":"JMIR Form Res"},{"issue":"1","key":"R3","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1097\/SPC.0000000000000478","article-title":"Online psychosocial interventions for posttreatment cancer survivors: an international evidence review and update","volume":"14","author":"Skrabal Ross","journal-title":"Curr Opin Support Palliat Care"},{"issue":"3","key":"R4","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.pec.2014.11.002","article-title":"A systematic review of types and efficacy of online interventions for cancer patients","volume":"98","author":"McAlpine","journal-title":"Patient Educ Couns"},{"issue":"3","key":"R5","doi-asserted-by":"publisher","DOI":"10.2196\/jmir.1772","article-title":"A systematic review of the impact of adherence on the effectiveness of e-therapies","volume":"13","author":"Donkin","journal-title":"J Med Internet Res"},{"issue":"3","key":"R6","doi-asserted-by":"publisher","DOI":"10.2196\/jmir.4.3.e17","article-title":"Issues in evaluating health websites in an Internet-based randomized controlled trial","volume":"4","author":"Eysenbach","journal-title":"J Med Internet Res"},{"issue":"6","key":"R7","doi-asserted-by":"publisher","DOI":"10.2196\/jmir.2104","article-title":"Persuasive system design does matter: a systematic review of adherence to web-based interventions","volume":"14","author":"Kelders","journal-title":"J Med Internet Res"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2020.00926","article-title":"The concept and components of engagement in different domains applied to eHealth: a systematic scoping review","volume":"11","author":"Kelders","journal-title":"Front Psychol"},{"issue":"4","key":"R9","doi-asserted-by":"publisher","DOI":"10.2196\/jmir.1672","article-title":"A holistic framework to improve the uptake and impact of eHealth technologies","volume":"13","author":"van Gemert-Pijnen","journal-title":"J Med Internet Res"},{"key":"R10","doi-asserted-by":"crossref","unstructured":"Kelders S Kip H Sanderman R van Gemert-Pijnen L . eHealth Research, Theory and Development. 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