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To address these issues, we developed and assessed the feasibility of a digital health platform, CRCWeb, to improve the accessibility of educational resources on symptom management for disadvantaged patients with CRC and their caregivers facing limited health literacy or low income. CRCWeb was developed through a stakeholder-centered participatory design approach. Two-phase semistructured interviews with patients, caregivers, and oncology experts informed the iterative design process. From the interviews, we developed the following 5 key design principles: user-friendly navigation, multimedia integration, concise and clear content, enhanced accessibility for individuals with vision and reading disabilities, and scalability for future content expansion. Initial feedback from iterative stakeholder engagements confirmed high user satisfaction, with participants rating CRCWeb an average of 3.98 out of 5 on the postintervention survey. Additionally, using generative artificial intelligence tools, including large language models like ChatGPT and multimedia generation tools such as Pictory, complex health care guidelines were transformed into concise, easily comprehensible multimedia content, and made accessible through CRCWeb. User engagement was notably higher among disadvantaged participants with limited health literacy or low income, who logged into the platform 2.52 times more frequently than nondisadvantaged participants. The structured development approach of CRCWeb demonstrates that generative artificial intelligence\u2013powered multimedia interventions can effectively address health care accessibility barriers faced by disadvantaged patients with CRC and caregivers with limited health literacy or low income. This structured approach highlights how digital innovations can enhance health care.<\/jats:p>","DOI":"10.2196\/68516","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T09:40:07Z","timestamp":1746438007000},"page":"e68516-e68516","source":"Crossref","is-referenced-by-count":7,"title":["Leveraging Artificial Intelligence for Digital Symptom Management in Oncology: The Development of CRCWeb"],"prefix":"10.2196","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5019-4402","authenticated-orcid":false,"given":"Darren","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9182-2928","authenticated-orcid":false,"given":"Yufen","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6558-4567","authenticated-orcid":false,"given":"Runze","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1611-2053","authenticated-orcid":false,"given":"Zhiyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2983-571X","authenticated-orcid":false,"given":"Delgersuren","family":"Bold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9478-5571","authenticated-orcid":false,"given":"Xiao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1010","published-online":{"date-parts":[[2025,6,16]]},"reference":[{"issue":"1","key":"R1","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3322\/caac.21820","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","journal-title":"CA Cancer J Clin"},{"issue":"6","key":"R2","doi-asserted-by":"publisher","first-page":"565","DOI":"10.3322\/caac.21788","article-title":"Patient navigation across the cancer care continuum: an overview of systematic reviews and emerging literature","volume":"73","author":"Chan","journal-title":"CA Cancer J Clin"},{"issue":"8","key":"R3","doi-asserted-by":"publisher","first-page":"4461","DOI":"10.1007\/s00520-020-05946-4","article-title":"Distinct profiles of multiple co-occurring symptoms in patients with gastrointestinal cancers receiving chemotherapy","volume":"29","author":"Lin","journal-title":"Support Care Cancer"},{"issue":"2","key":"R4","doi-asserted-by":"publisher","first-page":"E417","DOI":"10.1097\/NCC.0000000000000975","article-title":"Distinct sleep disturbance profiles in patients with gastrointestinal cancers receiving chemotherapy","volume":"45","author":"Lin","journal-title":"Cancer Nurs"},{"issue":"9","key":"R5","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-021-01274-4","article-title":"Disparities in health care and the digital divide","volume":"23","author":"Saeed","journal-title":"Curr Psychiatry Rep"},{"issue":"9 Suppl","key":"R6","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1097\/01.NAJ.0000336406.45248.4c","article-title":"Physical and mental health effects of family caregiving","volume":"108","author":"Schulz","journal-title":"Am J Nurs"},{"issue":"1","key":"R7","doi-asserted-by":"publisher","DOI":"10.2196\/48499","article-title":"A web-based dyadic intervention to manage psychoneurological symptoms for patients with colorectal cancer and their caregivers: protocol for a mixed methods study","volume":"12","author":"Lin","journal-title":"JMIR Res Protoc"},{"issue":"3","key":"R8","doi-asserted-by":"publisher","DOI":"10.5334\/egems.191","article-title":"Detecting risk of low health literacy in disadvantaged populations using area-based measures","volume":"5","author":"Knighton","journal-title":"EGEMS (Wash DC)"},{"issue":"2","key":"R9","doi-asserted-by":"publisher","DOI":"10.5001\/omj.2020.40","article-title":"Implications of language barriers for healthcare: a systematic review","volume":"35","author":"Al Shamsi","journal-title":"Oman Med J"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmedinf.2024.105474","article-title":"Generative artificial intelligence in healthcare: a scoping review on benefits, challenges and applications","volume":"188","author":"Moulaei","journal-title":"Int J Med Inform"},{"issue":"1","key":"R11","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7432849","article-title":"Communication needs of cancer patients and\/or caregivers: a critical literature review","volume":"2020","author":"Li","journal-title":"J Oncol"},{"key":"R12","unstructured":"Achiam J Adler S Agarwal S Ahmad L Akkaya I Aleman FL et al. 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