{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T18:55:35Z","timestamp":1782845735127,"version":"3.54.5"},"reference-count":50,"publisher":"JMIR Publications Inc.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Internet Res"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec sec-type=\"background\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Postoperative anxiety following voluntary medical male circumcision (VMMC) poses a significant health challenge, with limited telemedicine access and inadequate communication compromising recovery and adherence. Narrative-based interventions have shown promise in reducing psychological distress in other contexts, and large language models may enable automated follow-up, but their role in VMMC care remains underexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"objective\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We evaluated the effect of a narrative-enhanced tool (NET) on anxiety, sleep quality, quality of life, and pain management and identified risk factors for postoperative anxiety. We also assessed the feasibility of an artificial intelligence\u2013assisted consultation (AAC) system in improving follow-up efficiency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From October 1, 2023, to April 29, 2024, patients aged \u226515 years undergoing VMMC were recruited and randomized 1:1 to a standardized risk tool (SRT) or NET group. In addition to the routine postoperative communication, the NET group received a narrative video highlighting positive recovery experiences. Both groups accessed an AAC chatbot for automated follow-ups. Primary outcomes were anxiety levels measured by the 7-item Generalized Anxiety Disorder scale (GAD-7), sleep quality measured by Pittsburgh Sleep Quality Index, quality of life measured by 3-level EuroQoL 5D questionnaire, and pain levels measured by Numerical Rating Scale. Secondary outcomes included analgesic use, satisfaction, and health care worker efficiency. Repeated measures ANOVA assessed trends and regression identified risk factors for anxiety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Between October 1, 2023, and April 29, 2024, 671 eligible participants were enrolled, with 388 completing the 30-day follow-up (SRT group: n=189, mean age 26.21, SD 3.69 years; NET group: n=199, mean age 26.41, SD 3.56 years;\n                      <jats:italic>P<\/jats:italic>\n                      =.60). Both groups exhibited increased anxiety levels, diminished quality of life, and poorer sleep quality during the 30-day postoperative period. However, compared to SRT, the NET group demonstrated lower GAD-7 scores (7.06, SD 2.73 vs. 9.95, SD 3.50;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;.001), improved sleep quality (12.29, SD 3.57 vs 13.20, SD 3.54;\n                      <jats:italic>P<\/jats:italic>\n                      =.01), higher quality of life scores (0.87, SD 0.07 vs 0.84, SD 0.09;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;.001), more regular analgesic use (154\/173, 89.02% vs 100\/169, 59.17%;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;.001), reduced opioid consumption (5\/173, 2.89% vs 25\/169, 14.79%;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;.001), and higher pain medication satisfaction (4.21, SD 0.69 vs 3.76, SD 0.97;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;.001). Multivariate analysis identified SRT assignment, inability to recall opioid risk levels, hematoma, swelling, and pain as independent risk factors for elevated GAD-7 scores. Implementation of the AAC substantially reduced health care worker follow-up time (2.34, SD 1.95 min vs 7.85, SD 2.65 min;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The study demonstrates that narrative is effective in reducing anxiety, improving quality of life, and improving pain management post-VMMC. The integration of artificial intelligence into clinical follow-up protocols has the potential to enhance health care worker efficiency without compromising patient satisfaction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2196\/68573","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T21:11:07Z","timestamp":1763413867000},"page":"e68573-e68573","source":"Crossref","is-referenced-by-count":0,"title":["Application of Narrative and AI-Assisted Follow-Up After Voluntary Medical Male Circumcision: Multicenter, Double-Blind, Prospective, Randomized Controlled Trial"],"prefix":"10.2196","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9311-2834","authenticated-orcid":false,"given":"Linfeng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6990-5367","authenticated-orcid":false,"given":"Yueqiang","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9999-9944","authenticated-orcid":false,"given":"Gaojie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3371-8517","authenticated-orcid":false,"given":"Yong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3683-5587","authenticated-orcid":false,"given":"Guo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2815-9019","authenticated-orcid":false,"given":"Yu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9036-1022","authenticated-orcid":false,"given":"Qiao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0355-6384","authenticated-orcid":false,"given":"Jiang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9193-0339","authenticated-orcid":false,"given":"Jiajia","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1675-0128","authenticated-orcid":false,"given":"Hong","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0910-2054","authenticated-orcid":false,"given":"Qingyu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5271-3904","authenticated-orcid":false,"given":"Ziling","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1493-4061","authenticated-orcid":false,"given":"Wei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3874-3075","authenticated-orcid":false,"given":"Jiayu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1010","published-online":{"date-parts":[[2025,11,17]]},"reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmedinf.2023.105173","article-title":"Performance and exploration of ChatGPT in medical examination, records and education in Chinese: pave the way for medical AI","volume":"177","author":"Wang","journal-title":"Int J Med Inform"},{"issue":"1","key":"R2","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1097\/JS9.0000000000001989","article-title":"Advancements in AI-driven oncology: assessing ChatGPT\u2019s impact from GPT-3.5 to GPT-4o","volume":"111","author":"Mu","journal-title":"Int J Surg"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1220160","article-title":"Healthcare professionals\u2019 and patients\u2019 assessments of listed mobile health apps in China: a qualitative study","volume":"11","author":"Liu","journal-title":"Front Public Health"},{"issue":"11","key":"R4","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.48482","article-title":"Towards ideal health ecosystem with artificial intelligence-driven medical services in India: an overview","volume":"15","author":"Kumar","journal-title":"Cureus"},{"issue":"1","key":"R5","doi-asserted-by":"publisher","DOI":"10.1111\/hel.13055","article-title":"Comparative analysis of large language models in medical counseling: a focus on Helicobacter pylori infection","volume":"29","author":"Kong","journal-title":"Helicobacter"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.2196\/54706","article-title":"Physician versus large language model chatbot responses to web-based questions from autistic patients in Chinese: cross-sectional comparative analysis","volume":"26","author":"He","journal-title":"J Med Internet Res"},{"issue":"9","key":"R7","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1093\/jamia\/ocae087","article-title":"Lingdan: enhancing encoding of traditional Chinese medicine knowledge for clinical reasoning tasks with large language models","volume":"31","author":"Hua","journal-title":"J Am Med Inform Assoc"},{"issue":"12","key":"R8","doi-asserted-by":"publisher","first-page":"e917","DOI":"10.1016\/S2589-7500(23)00201-7","article-title":"Large language models and their impact in ophthalmology","volume":"5","author":"Betzler","journal-title":"Lancet Digit Health"},{"issue":"6","key":"R9","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering11060521","article-title":"A comparative sentiment analysis of Greek clinical conversations using BERT, RoBERTa, GPT-2, and XLNet","volume":"11","author":"Chatzimina","journal-title":"Bioengineering (Basel)"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1177\/20552076241227132","article-title":"Reliability of ChatGPT for performing triage task in the emergency department using the Korean triage and acuity scale","volume":"10","author":"Kim","journal-title":"Digit Health"},{"issue":"10","key":"R11","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.36483","article-title":"Accuracy and reliability of chatbot responses to physician questions","volume":"6","author":"Goodman","journal-title":"JAMA Netw Open"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.2196\/51282","article-title":"Assessing GPT-4\u2019s performance in delivering medical advice: comparative analysis with human experts","volume":"10","author":"Jo","journal-title":"JMIR Med Educ"},{"issue":"4","key":"R13","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1007\/s12160-014-9685-9","article-title":"Exercise as treatment for anxiety: systematic review and analysis","volume":"49","author":"Stonerock","journal-title":"Ann Behav Med"},{"issue":"5","key":"R14","doi-asserted-by":"publisher","DOI":"10.2196\/jmir.6775","article-title":"Efficacy of a web-based guided recommendation service for a curated list of readily available mental health and well-being mobile apps for young people: randomized controlled trial","volume":"19","author":"Bidargaddi","journal-title":"J Med Internet Res"},{"issue":"7","key":"R15","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1007\/s11606-021-06988-y","article-title":"Readability of patient discharge instructions","volume":"37","author":"Burns","journal-title":"J Gen Intern Med"},{"issue":"1","key":"R16","doi-asserted-by":"publisher","DOI":"10.1177\/15579883241228243","article-title":"Comparing the strength of associations between male genital problems and mental illnesses and sleep disorders","volume":"18","author":"Merrill","journal-title":"Am J Mens Health"},{"issue":"S1","key":"R17","doi-asserted-by":"publisher","first-page":"S45","DOI":"10.2105\/AJPH.2021.306511","article-title":"A multicentered randomized controlled trial comparing the effectiveness of pain treatment communication tools in emergency department patients with back or kidney stone pain","volume":"112","author":"Meisel","journal-title":"Am J Public Health"},{"issue":"4","key":"R18","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1007\/s00737-018-0822-5","article-title":"Women generating narratives after an unwanted prenatal diagnosis result: randomized controlled trial","volume":"21","author":"Rocha","journal-title":"Arch Womens Ment Health"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1016\/j.pec.2022.10.348","article-title":"Development of a web-based, theory-guided narrative intervention for women at elevated risk for breast cancer","volume":"106","author":"Katz","journal-title":"Patient Educ Couns"},{"issue":"6","key":"R20","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1016\/j.jopan.2023.04.007","article-title":"Effects of videos and therapeutic music on preoperative anxiety and postoperative anxiety and pain levels in boys who undergo circumcision","volume":"38","author":"Yeniay","journal-title":"J Perianesth Nurs"},{"issue":"6","key":"R21","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1016\/j.pmn.2024.06.007","article-title":"Effects of virtual reality on pain and anxiety during children\u2019s circumcision: a systematic review and meta-analysis","volume":"25","author":"Chen","journal-title":"Pain Manag Nurs"},{"issue":"7","key":"R22","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1111\/iju.15184","article-title":"The effect of nursing interventions with therapeutic play and video animations prepared with psychodrama technique in reducing fear, anxiety, and pain of children at male circumcision: a randomized controlled study","volume":"30","author":"Tuncay","journal-title":"Int J Urol"},{"issue":"4","key":"R23","doi-asserted-by":"publisher","DOI":"10.2196\/jmir.1923","article-title":"CONSORT-EHEALTH: improving and standardizing evaluation reports of Web-based and mobile health interventions","volume":"13","author":"Eysenbach","journal-title":"J Med Internet Res"},{"key":"R24","unstructured":"Narrative enhenced tool (video). Google Drive. URL: https:\/\/drive.google.com\/file\/d\/1PpVbejWLZJXNNiDtRiDCPjcT2o-NJHCL\/view [Accessed 31-10-2025]"},{"key":"R25","unstructured":"In-depth investigation of drug addiction (part i) \u2014 behind the angel lies the devil. YouTube. 2019. URL: https:\/\/www.youtube.com\/watch?v=-YmBvsxazrk [Accessed 31-10-2025]"},{"issue":"6","key":"R26","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1001\/jama.2024.0018","article-title":"AI\u2019s threat to the medical profession","volume":"331","author":"Fogo","journal-title":"JAMA"},{"issue":"4","key":"R27","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.26599\/BDMA.2024.9020044","article-title":"MedBench: a comprehensive, standardized, and reliable benchmarking system for evaluating Chinese medical large language models","volume":"7","author":"Liu","journal-title":"Big Data Min Anal"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2023.04.065","article-title":"A network analysis of anxiety and depression symptoms in Chinese disabled elderly","volume":"333","author":"Zhang","journal-title":"J Affect Disord"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.01.032","article-title":"Sensitivity to change and minimal clinically important difference of the 7-item Generalized Anxiety Disorder Questionnaire (GAD-7)","volume":"265","author":"Toussaint","journal-title":"J Affect Disord"},{"issue":"7","key":"R30","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.5498\/wjp.v14.i7.1009","article-title":"Impact of comorbid subthreshold depressive symptoms on cancer-related fatigue and complications in adults with leukemia","volume":"14","author":"Liu","journal-title":"World J Psychiatry"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.11.08001","article-title":"Population norms for the EQ-5D-3L in China derived from the 2013 National Health Services Survey","volume":"11","author":"Yao","journal-title":"J Glob Health"},{"issue":"5","key":"R32","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/j.jval.2014.05.007","article-title":"Chinese time trade-off values for EQ-5D health states","volume":"17","author":"Liu","journal-title":"Value Health"},{"issue":"11","key":"R33","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1016\/j.jval.2018.04.1370","article-title":"Time trade-off value set for EQ-5D-3L based on a nationally representative Chinese population survey","volume":"21","author":"Zhuo","journal-title":"Value Health"},{"issue":"4","key":"R34","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1136\/jnnp.51.4.481","article-title":"Pain intensity measurements in patients with acute pain receiving afferent stimulation","volume":"51","author":"Ekblom","journal-title":"J Neurol Neurosurg Psychiatr"},{"issue":"3","key":"R35","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1111\/j.1553-2712.2001.tb01310.x","article-title":"Ability of patients to accurately recall the severity of acute painful events","volume":"8","author":"Singer","journal-title":"Acad Emerg Med"},{"issue":"1","key":"R36","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1097\/PEC.0b013e31827b2299","article-title":"The Wong-Baker pain FACES scale measures pain, not fear","volume":"29","author":"Garra","journal-title":"Pediatr Emerg Care"},{"issue":"1","key":"R37","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1136\/acupmed-2015-010852","article-title":"Acupuncture for pain control after caesarean section: a prospective observational pilot study","volume":"34","author":"Hesse","journal-title":"Acupunct Med"},{"issue":"6","key":"R38","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1111\/j.1526-4637.2005.00072.x","article-title":"Predicting aberrant behaviors in opioid-treated patients: preliminary validation of the opioid risk tool","volume":"6","author":"Webster","journal-title":"Pain Med"},{"issue":"5","key":"R39","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1037\/\/0022-3514.79.5.701","article-title":"The role of transportation in the persuasiveness of public narratives","volume":"79","author":"Green","journal-title":"J Pers Soc Psychol"},{"issue":"6","key":"R40","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1080\/10503307.2020.1847345","article-title":"Systematic review and meta-analyses of the long-term efficacy of narrative exposure therapy for adults, children and perpetrators","volume":"31","author":"Siehl","journal-title":"Psychother Res"},{"issue":"7","key":"R41","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1007\/s00383-010-2632-3","article-title":"Minimally invasive circumcision with a novel plastic clamp technique: a review of 7,500 cases","volume":"26","author":"Senel","journal-title":"Pediatr Surg Int"},{"issue":"2","key":"R42","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1111\/j.1442-2042.2012.03132.x","article-title":"Circumcision with a novel disposable device in Chinese children: a randomized controlled trial","volume":"20","author":"Pan","journal-title":"Int J Urol"},{"key":"R43","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2020.06.018","article-title":"Modified circumcision using the disposable circumcision suture device in children: a randomized controlled trial","volume":"143","author":"Rao","journal-title":"Urology"},{"issue":"10","key":"R44","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.36100","article-title":"Generative artificial intelligence for chest radiograph interpretation in the emergency department","volume":"6","author":"Huang","journal-title":"JAMA Netw Open"},{"issue":"8","key":"R45","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.29289","article-title":"Association of artificial intelligence-aided chest radiograph interpretation with reader performance and efficiency","volume":"5","author":"Ahn","journal-title":"JAMA Netw Open"},{"issue":"3","key":"R46","doi-asserted-by":"publisher","first-page":"e841","DOI":"10.1210\/clinem\/dgae235","article-title":"Comparing ChatGPT\u2019s and surgeon\u2019s responses to thyroid-related questions from patients","volume":"110","author":"Guo","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"R47","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1001\/jamainternmed.2023.1838","article-title":"Comparing physician and artificial intelligence chatbot responses to patient questions posted to a public social media forum","volume":"183","author":"Ayers","journal-title":"JAMA Intern Med"},{"issue":"1","key":"R48","doi-asserted-by":"publisher","DOI":"10.1186\/s12978-024-01738-9","article-title":"A qualitative assessment of the impact of a community-embedded intervention on beneficiaries\u2019 attitudes and beliefs about adolescent sexual reproductive health in Ebonyi State, Southeast, Nigeria","volume":"21","author":"Agu","journal-title":"Reprod Health"},{"issue":"4","key":"R49","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1037\/ort0000677","article-title":"Barriers experienced by emerging adults in discussing their sexuality with parents and health care providers: a mixed-method study","volume":"93","author":"S\u00e1nchez","journal-title":"Am J Orthopsychiatry"},{"issue":"1","key":"R50","doi-asserted-by":"publisher","DOI":"10.1038\/s41746-024-01157-x","article-title":"The ethics of ChatGPT in medicine and healthcare: a systematic review on large language models (LLMs)","volume":"7","author":"Haltaufderheide","journal-title":"NPJ Digit Med"}],"container-title":["Journal of Medical Internet Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jmir.org\/2025\/1\/e68573","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T17:55:29Z","timestamp":1782842129000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jmir.org\/2025\/1\/e68573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,17]]},"references-count":50,"URL":"https:\/\/doi.org\/10.2196\/68573","relation":{},"ISSN":["1438-8871"],"issn-type":[{"value":"1438-8871","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,17]]},"article-number":"v27i1e68573"}}