{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T18:56:40Z","timestamp":1782845800673,"version":"3.54.5"},"reference-count":20,"publisher":"JMIR Publications Inc.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMIR Diabetes"],"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n The 75-g oral glucose tolerance test (OGTT) remains the optimal diagnostic test for use in pregnancy but needs to be performed in the clinical setting. The GTT@home OGTT device offers the potential to enable patients to perform the test at home using capillary blood samples.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n This study aimed to determine the accuracy of the GTT@home device compared to the routine National Health Service laboratory reference method using blood samples during an OGTT from pregnant women at high risk of developing gestational diabetes mellitus (GDM).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A total of 65 women (aged >18 y), at high risk for GDM (per the National Institute for Health and Care Excellence guidelines) were recruited for this performance evaluation. Following an overnight fast, participants went for a 75-g OGTT. Fasting and 2-hour capillary glucose levels were measured using the GTT@home device with corresponding venous samples measured in the laboratory.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The complete data for analysis was available for 61\/65 devices. The overall bias for the GTT@home device was +0.16 mmol\/L. Correlation analysis of the clinical performance of the two methods using a surveillance error grid showed 79.8% of results in the lowest, 16.9% in the \u201cslight, lower\u201d and 2.4% in the \u201cslight, higher\u201d risk categories. Only 0.8% were \u201cmoderate, lower\u201d risk, and none were in any higher risk categories. There was agreement in the classification in 54\/61 cases. The GTT@home device under-classified 2 cases and over-classified 5 cases.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The GTT@home device worked well in a controlled, antenatal clinical setting. Differences in classification observed were generally due to small differences in glucose values close to the diagnostic cut-offs. The GTT@home device shows promise for home testing of glucose tolerance in pregnant women.<\/jats:p>\n <\/jats:sec>","DOI":"10.2196\/69695","type":"journal-article","created":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T14:50:06Z","timestamp":1746888606000},"page":"e69695-e69695","source":"Crossref","is-referenced-by-count":0,"title":["Use of the GTT@home Oral Glucose Tolerance Test Kit in Gestational Diabetes Mellitus: Performance Evaluation Study"],"prefix":"10.2196","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6022-862X","authenticated-orcid":false,"given":"Gareth J","family":"Dunseath","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7206-6530","authenticated-orcid":false,"given":"Stephen D","family":"Luzio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0915-9312","authenticated-orcid":false,"given":"Wai Yee","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5841-8309","authenticated-orcid":false,"given":"Sharon N","family":"Parsons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3111-5593","authenticated-orcid":false,"given":"Nicola","family":"John","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6400-6933","authenticated-orcid":false,"given":"Mahmoud","family":"Chokor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7767-9715","authenticated-orcid":false,"given":"Michael","family":"Atkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1671-627X","authenticated-orcid":false,"given":"Rajesh","family":"Peter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1010","published-online":{"date-parts":[[2026,2,11]]},"reference":[{"key":"R1","unstructured":"Centers for Disease Control and Prevention. National diabetes fact sheet: general information and national estimates on diabetes in the United States, 2007. US Department of Health and Human Services, Centers for Disease Control and Prevention; 2008. URL: https:\/\/stacks.cdc.gov\/view\/cdc\/5613\/cdc_5613_DS1.pdf [Accessed 28-01-2026]"},{"key":"R2","unstructured":"NICE guideline NG3 diabetes in pregnancy: management from preconception to the postnatal period. NICE. Feb 25, 2015. URL: https:\/\/www.nice.org.uk\/guidance\/ng3 [Accessed 28-01-2026]"},{"issue":"5","key":"R3","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1111\/1471-0528.16482","article-title":"Impact of changes to national UK Guidance on testing for gestational diabetes screening during a pandemic: a single-centre observational study","volume":"128","author":"van-de-l\u2019Isle","journal-title":"BJOG"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1016\/j.deman.2021.100023","article-title":"Performance of guidelines for the screening and diagnosis of gestational diabetes mellitus during the COVID-19 pandemic: a scoping review of the guidelines and diagnostic studies evaluating the recommended testing strategies","volume":"3","author":"Curtis","journal-title":"Diabet Epidemiol Manag"},{"issue":"3","key":"R5","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.pcd.2015.11.003","article-title":"Which sample tube should be used for routine glucose determination?","volume":"10","author":"Bonetti","journal-title":"Prim Care Diabetes"},{"issue":"7-8","key":"R6","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/j.clinbiochem.2014.01.011","article-title":"The shift from fluoride\/oxalate to acid citrate\/fluoride blood collection tubes for glucose testing - 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