{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T18:57:41Z","timestamp":1782845861351,"version":"3.54.5"},"reference-count":18,"publisher":"JMIR Publications Inc.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMIR Res Protoc"],"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Noncommunicable diseases, particularly diabetes, pose a growing global burden, with India disproportionately affected. India also has a rich repository of traditional medical systems\u2014Ayurveda, yoga and naturopathy, Unani, Siddha, Sowa Rigpa, and homeopathy (AYUSH)\u2014collectively governed under the Ministry of Ayush. These systems adopt a personalized and integrative approach to diabetes management, addressing glycemic control alongside metabolic and lifestyle factors. Despite growing use and evidence for AYUSH interventions, standardized evaluation methods remain limited.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n This study aims to quantitatively evaluate the evidence status for AYUSH interventions for the management of prediabetes and type 2 diabetes mellitus and establish a road map of evidence through research for better outcomes in the future.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n The systematic review will be conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines and is registered in PROSPERO. All primary study designs, including randomized controlled trials, nonrandomized controlled trials, parallel-arm intervention trials, pretest-posttest trials, observational studies (including cross-sectional, case-control, and cohort studies), and case series and case reports will be assessed. Systematic reviews and meta-analyses will be screened for background information and identification of relevant primary studies but will not be included in the evidence synthesis. Studies involving AYUSH interventions either as stand-alone therapies or as an add-on to standard care will be reviewed. Electronic databases along with AYUSH-specific sources, including PubMed, CENTRAL, clinical trial registries, AYUSH Research Portal, MEDLINE, Scopus, Web of Science, Embase, Digital Helpline for Ayurveda Research Articles, and IndMED, will be searched using database-specific search strategies combining AYUSH-related and diabetes-specific keywords with Boolean operators. Outcome measures will include clinical recovery, biochemical parameters, quality of life, and adverse events. Data will be synthesized systematically and represented through an evidence map.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Database searches and pilot-testing of strategies are planned to commence in September 2025. Screening of eligible studies, data extraction, and quality assessment are planned for December 2025; data compilation and manuscript preparation will be conducted from July 2026 to October 2026; and the final systematic review and evidence map are anticipated by December 2026. Publication of the results is expected in early 2027. Anticipated findings will include a systematic integration of data relevant to the efficacy and safety profiles of AYUSH interventions for prediabetes and type 2 diabetes accompanied by an evidence map showcasing the allocation and reliability of the current evidence base on different AYUSH modalities.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n This review seeks to consolidate and evaluate existing data to facilitate evidence-based integration of Indian traditional medicine in diabetes management. The resulting evidence map will serve as a strategic tool for clinical research, health care policy, and future systematic reviews in the field of integrative medicine.<\/jats:p>\n <\/jats:sec>","DOI":"10.2196\/70617","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T22:25:05Z","timestamp":1770157505000},"page":"e70617-e70617","source":"Crossref","is-referenced-by-count":0,"title":["Status of Evidence on the Efficacy and Safety of Indian Traditional Medicine for Prediabetes and Type 2 Diabetes Mellitus: Protocol for a Systematic Review and Evidence Map 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