{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T18:58:41Z","timestamp":1782845921864,"version":"3.54.5"},"reference-count":41,"publisher":"JMIR Publications Inc.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMIR Mhealth Uhealth"],"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n The management of chronic obstructive pulmonary disease (COPD) places a significant burden on health care systems worldwide. Home noninvasive positive pressure ventilation (NPPV) is an established treatment option associated with significant benefits for patients with COPD and hypercapnic chronic respiratory failure. Internet of Things (IoT)\u2013based management may improve communication between patients and physicians and strengthen the integration and comprehensiveness of home NPPV telemonitoring. However, the economic value of such systems remains insufficiently understood.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n This study aimed to assess the cost-effectiveness of IoT-based management versus standard management of home NPPV in patients with COPD and hypercapnic chronic respiratory failure.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A Markov decision analytic model was developed to simulate real-world COPD progression and predict health outcomes and costs associated with IoT-based and standard management of home NPPV. COPD progression consisted of 4 health states: stable period, nonserious exacerbation period, serious exacerbation period, and death. Efficacy and cost inputs were primarily sourced from a published multicenter, prospective, randomized controlled trial and supplemented by official Chinese databases where necessary. Quality-adjusted life years (QALYs) were used as effect indicators for this model, which were derived from COPD Assessment Test scores. The discounted lifetime cost per QALY gained was calculated from the Chinese health care payer perspective, and sensitivity analyses were conducted to test the robustness of model results across different assumptions.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Compared with standard NPPV, IoT-based NPPV increased costs by \u00a53607.26 and improved QALYs by 0.24 per person across the lifetime horizon, resulting in an incremental cost-effectiveness ratio of \u00a515,030.25 per QALY, with a 93.6% probability of being cost-effective at the given willingness-to-pay threshold (currency conversion to US dollars was based on the average exchange rate in 2019 [US $1=\u00a56.9]). Base case results were also robust to multiple one-way sensitivity analyses, with the main drivers being hospitalization costs for the standard and IoT-based NPPV groups during the serious exacerbation period.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n IoT-based NPPV was cost-effective compared with standard NPPV for patients with COPD and hypercapnic chronic respiratory failure.<\/jats:p>\n <\/jats:sec>","DOI":"10.2196\/71340","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:40:07Z","timestamp":1776732007000},"page":"e71340-e71340","source":"Crossref","is-referenced-by-count":0,"title":["Cost-Effectiveness of Internet of Things\u2013Based Management of Home Noninvasive Positive Pressure Ventilation in Patients With Chronic Obstructive Pulmonary Disease and Hypercapnic Chronic Respiratory Failure: Trial-Based Economic Evaluation"],"prefix":"10.2196","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6376-9528","authenticated-orcid":false,"given":"Ruihua","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7069-1579","authenticated-orcid":false,"given":"Jiu","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7464-6620","authenticated-orcid":false,"given":"Yueying","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1465-7752","authenticated-orcid":false,"given":"Xi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3449-0927","authenticated-orcid":false,"given":"Yinghao","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3028-891X","authenticated-orcid":false,"given":"Weipeng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7616-1763","authenticated-orcid":false,"given":"Chenjun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3373-6631","authenticated-orcid":false,"given":"Yuanlin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6233-3973","authenticated-orcid":false,"given":"Hui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1010","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"R1","unstructured":"Healthy China initiative (2019-2030) [Article in Chinese]. 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