{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T18:58:53Z","timestamp":1782845933989,"version":"3.54.5"},"reference-count":9,"publisher":"JMIR Publications Inc.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMIR Form Res"],"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Advances in antiretroviral therapy have transformed HIV into a manageable chronic condition, allowing people living with HIV to live longer. However, with aging, people living with HIV face increased risks of lifestyle-related diseases and unaddressed psychosocial issues, including stigma, discrimination, and mental health concerns. Patient-reported outcomes are essential tools in person-centered care and have demonstrated clinical utility in oncology and rheumatology; yet remains underutilized in infectious disease settings. Recently, the European AIDS Clinical Society has recommended electronic patient-reported outcome (ePRO) systems to support HIV care.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n This study aimed to evaluate the feasibility and clinical utility of a smartphone-based ePRO system specifically developed for people living with HIV in Japan.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A retrospective study was conducted among people living with HIV who attended the HIV outpatient clinic at Teikyo University Hospital between July and September 2022. Participants who consented to use the ePRO system installed a smartphone app and completed the HIV symptom index prior to their clinic visit. Physicians reviewed the responses during consultations; following the visits, patients completed a usability survey addressing clarity, response time, satisfaction, communication quality, and intention for future use. Medical records were reviewed to determine any new symptoms, findings, or medical actions that had not been documented in the previous two years.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n A total of 27 people living with HIV (median age, 46 years; 100% male) used the ePRO app, and 25 (93%) completed the postuse questionnaire. Of these, 19\/25 (76%) completed the Symptom Index within 5 minutes, while one participant required more than 15 minutes. Regarding usability, 76% (n=19) reported being satisfied or very satisfied, and 76% (n=19) found the system useful in improving communication with their provider. Additionally, 76% (n=19) expressed willingness to use the system again, while 5 (20%) participants indicated interest only if improvements were made. Medical record analysis revealed that 17\/27 patients (63%) had new clinical information documented, including mental health symptoms (n=7, 26%), skin problems (n=7, 26%), and new diagnoses or treatment changes in 6 (22%) cases. Over 40% (n=11) of patients reported issues such as anxiety, insomnia, dermatological symptoms, or concerns related to body image.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n This pilot study demonstrated that a smartphone-based ePRO system for people living with HIV is feasible and well-accepted in real-world clinical practice. It facilitated early detection of psychosocial and physical issues that may otherwise be overlooked in routine care and improved patient\u2013provider communication. These findings support the integration of ePRO systems into HIV care and underscore the need for further refinement of the app and prospective studies to assess long-term impact on patient outcomes and quality of care.<\/jats:p>\n <\/jats:sec>","DOI":"10.2196\/71493","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T04:20:09Z","timestamp":1744258809000},"page":"e71493-e71493","source":"Crossref","is-referenced-by-count":1,"title":["Feasibility of an Electronic Patient-Reported Outcome System in People Living With HIV: Retrospective Analysis of a Mobile App-Based Pilot Study"],"prefix":"10.2196","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3633-4243","authenticated-orcid":false,"given":"Yusuke","family":"Yoshino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5430-9909","authenticated-orcid":false,"given":"Yoshitaka","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8133-6635","authenticated-orcid":false,"given":"Yoshitaka","family":"Wakabayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2350-2922","authenticated-orcid":false,"given":"Takatoshi","family":"Kitazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1010","published-online":{"date-parts":[[2025,6,10]]},"reference":[{"issue":"12","key":"R1","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1093\/cid\/ciu701","article-title":"Cross-sectional comparison of the prevalence of age-associated comorbidities and their risk factors between HIV-infected and uninfected individuals: the AGEhIV cohort study","volume":"59","author":"Schouten","journal-title":"Clin Infect Dis"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.3389\/fgwh.2024.1469465","article-title":"Positive, Open, Proud: an adapted disclosure-based intervention to reduce HIV stigma","volume":"5","author":"Chenneville","journal-title":"Front Glob Womens Health"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-9-86","article-title":"Measuring patient-reported outcomes: moving beyond misplaced common sense to hard science","volume":"9","author":"McKenna","journal-title":"BMC Med"},{"issue":"11","key":"R4","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1016\/S1470-2045(06)70910-X","article-title":"Patient versus clinician symptom reporting using the National Cancer Institute Common Terminology Criteria for Adverse Events: results of a questionnaire-based study","volume":"7","author":"Basch","journal-title":"Lancet Oncol"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S273266","article-title":"Clinical efficacy of baloxavir marboxil in the treatment of seasonal influenza in adult patients: a prospective observational study","volume":"13","author":"Yoshino","journal-title":"Int J Gen Med"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S309920","article-title":"The clinical effect of seasonal flu vaccination on health-related quality of life","volume":"14","author":"Yoshino","journal-title":"Int J Gen Med"},{"issue":"11","key":"R7","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1111\/hiv.13542","article-title":"Major revision version 12.0 of the European AIDS Clinical Society guidelines 2023","volume":"24","author":"Ambrosioni","journal-title":"HIV Med"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1016\/s0895-4356(01)00449-8","article-title":"Development and validation of a self-completed HIV symptom index","volume":"54 Suppl 1","author":"Justice","journal-title":"J Clin Epidemiol"},{"issue":"1","key":"R9","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1089\/regen.2024.0005","article-title":"Clinical value of patient-reported outcomes for people living with HIV: mini-review","volume":"4","author":"Yoshino","journal-title":"Re:GEN Open"}],"container-title":["JMIR Formative Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/formative.jmir.org\/2025\/1\/e71493","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T18:00:53Z","timestamp":1782842453000},"score":1,"resource":{"primary":{"URL":"https:\/\/formative.jmir.org\/2025\/1\/e71493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,10]]},"references-count":9,"URL":"https:\/\/doi.org\/10.2196\/71493","relation":{},"ISSN":["2561-326X"],"issn-type":[{"value":"2561-326X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,10]]},"article-number":"v9i12e71493"}}