{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:08:49Z","timestamp":1788260929455,"version":"build-2803163510"},"reference-count":38,"publisher":"JMIR Publications Inc.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMIR Res Protoc"],"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Type 2 diabetes mellitus (T2DM) is a critical global health issue, especially in low- and middle-income countries like Afghanistan and Pakistan, where many cases remain undiagnosed and specialized care is costly. Community Health Participatory Research, which actively involves community members in addressing health issues, is increasingly recognized as an effective approach to deliver sustainable and culturally relevant health solutions. Participatory Learning and Action (PLA), a method of Community Health Participatory Research, was implemented in the D-Magic (Diabetes Mellitus: Action Through Community Groups or mHealth Information for Better Control) trial in Bangladesh that empowered communities to identify challenges and develop locally relevant strategies to prevent and control T2DM.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n This study aims to adapt the PLA-based D-Magic intervention for the prevention and control of T2DM in rural and urban communities of Afghanistan and Pakistan.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This trial, titled \u201cEngagement of Community Through Participatory Learning and Action for Control and Prevention of Type 2 Diabetes and Its Risk Factors\u201d (EMPOWER-D), will systematically adapt the D-Magic intervention using the ADAPT guidance framework. The study will be conducted across 3 sites: rural Afghanistan (Kabul), rural Pakistan (Peshawar and Swabi), and urban Pakistan (Karachi). Stakeholders and community members will be involved to ensure cultural relevance and authenticity. The process includes identifying barriers and facilitators to the implementation of community-based interventions through a qualitative study and a scoping review, co-designing intervention materials, and piloting for feasibility and effectiveness.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n EMPOWER-D was funded and launched in November 2022 by the United Kingdom\u2019s National Institute for Health and Care Research (NIHR203248). Following a year-long development phase, the adaptation protocol was finalized, and a mock run of the interviews was conducted. Recruitment and qualitative data collection, including in-depth interviews and focus group discussions, began in July 2024 and have been completed in Peshawar, Swabi, and Karachi. As of January 2025, data collection has commenced in Afghanistan. Results are anticipated to be published in mid-2026 following the completion of data analysis.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The EMPOWER-D adaptation will align the PLA-based intervention with the local sociocultural context, ensuring health equity and participation. Building on the D-Magic trial\u2019s success, this adaptation will ensure the intervention\u2019s effectiveness and cost-effectiveness in preventing and managing T2DM, not only in Afghanistan and Pakistan but also in other low- and middle-income countries.<\/jats:p>\n <\/jats:sec>","DOI":"10.2196\/71602","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T14:00:08Z","timestamp":1760623208000},"page":"e71602-e71602","source":"Crossref","is-referenced-by-count":1,"title":["Application of the ADAPT Framework to Contextualize a Participatory Learning and Action Community Intervention for the Prevention and Control of Type 2 Diabetes Mellitus in Urban and Rural Settings in Afghanistan and Pakistan: Protocol for Intervention Adaptation"],"prefix":"10.2196","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6335-0516","authenticated-orcid":false,"given":"Amber","family":"Tahir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9437-4203","authenticated-orcid":false,"given":"Noor","family":"Sanauddin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7068-7286","authenticated-orcid":false,"given":"Sara","family":"Imtiaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4023-4693","authenticated-orcid":false,"given":"Nadia","family":"Khaleeq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2528-2687","authenticated-orcid":false,"given":"Mariam","family":"AbdeAli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7737-708X","authenticated-orcid":false,"given":"Asima","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7318-5218","authenticated-orcid":false,"given":"Farrukh","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8580-0327","authenticated-orcid":false,"given":"Hannah Maria","family":"Jennings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2744-0175","authenticated-orcid":false,"given":"Rubia","family":"Zafar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8813-4801","authenticated-orcid":false,"given":"Khalid","family":"Rehman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3304-9276","authenticated-orcid":false,"given":"Abdul Rahman","family":"Shahab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9080-2220","authenticated-orcid":false,"given":"Saima","family":"Afaq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1010","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"issue":"6","key":"R1","doi-asserted-by":"publisher","first-page":"e340","DOI":"10.1016\/s2666-7568(21)00089-1","article-title":"The state of diabetes treatment coverage in 55 low-income and middle-income countries: a cross-sectional study of nationally representative, individual-level data in 680 102 adults","volume":"2","author":"Flood","journal-title":"Lancet Healthy Longev"},{"key":"R2","doi-asserted-by":"crossref","unstructured":"Mueller H Techasunthornwat C . 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