{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:44:03Z","timestamp":1792107843299,"version":"4.4.0"},"reference-count":35,"publisher":"JMIR Publications Inc.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMIR Public Health Surveill"],"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Varicella is a prevalent respiratory infectious disease. Continuous monitoring is essential to understand evolving epidemiological patterns, particularly given the impact of vaccination and recent nonpharmacological interventions.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n This study aims to monitor the epidemiological characteristics of varicella and the changes in breakthrough cases to inform adjustments in immunization strategies and enhance prevention efforts.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n From 2010 to 2023, varicella incidence was monitored using active (2010-2011) and passive (2012-2023) surveillance methods. Data were obtained from the Chinese Center for Disease Prevention and Control\u2019s information system and Ningbo\u2019s Immunization Information System. The study period was divided into four intervals to analyze trends. A birth cohort (2009-2013) was established to examine breakthrough cases. A recurrent neural network model was constructed for deep learning analysis of incidence trends and the impact of nonpharmaceutical interventions.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Between 2010 and 2023, a total of 70,163 varicella cases were reported in Ningbo. Seasonal distribution indicated two incidence troughs before 2020 and only one from 2020 to 2023. The predominant age of onset was 10\u201014 years, accounting for 23.93% (16,795\/70,163) of cases. From 2010 to 2013, the highest incidence was among children aged 5\u20109 years; from 2014 to 2019, it shifted to those aged 10\u201014 years; and from 2020 to 2023, it was primarily among individuals aged 15\u201019 years. Following the introduction of a second vaccine dose (2014\u20102019), incidence among children younger than 10 years of age decreased, notably by 59.54% in those aged 1\u20104 years. Conversely, incidence among individuals aged 10 years and older increased, particularly by 123.78% in the 15\u201019 years age group, with a significant upward trend (\n P<\/jats:italic>\n trend<\/jats:sub>\n <.001). From 2020 to 2023, although incidence rates increased across age groups 15 years and older, the rise was modest. The average annual incidence rate of breakthrough cases after one vaccine dose was 83.40\/100,000 (range, 51.21\u2010119.50\/100,000), significantly higher than the 24.80\/100,000 (range, 17.67\u201032.90\/100,000) observed after two doses. However, the incidence of breakthrough cases after the first dose declined following the implementation of the 2-dose program. The median time from vaccination to breakthrough case occurrence was 27 (IQR 17.50\u201048) months. The recurrent neural network model demonstrated high accuracy (mean squared error, 49.96) and indicated that implementation of emergency response and community lockdown measures in early 2020 correlated with a divergence between predicted and actual case numbers, suggesting an impact of nonpharmaceutical interventions on varicella transmission.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The significant shifts in varicella epidemiology between 2010 and 2023 highlight the importance of continuous monitoring and proactive immunization adjustments. We recommend enhanced varicella surveillance focusing on adult populations, and a targeted increase in 2-dose vaccine coverage, particularly in high-risk environments such as high schools and universities.<\/jats:p>\n <\/jats:sec>","DOI":"10.2196\/71691","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T13:55:06Z","timestamp":1744725306000},"page":"e71691-e71691","source":"Crossref","is-referenced-by-count":6,"title":["Changes in Epidemiological Characteristics of Varicella and Breakthrough Cases in Ningbo, China, From 2010 to 2023: Surveillance 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