{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:35:19Z","timestamp":1790613319704,"version":"4.1.0"},"reference-count":73,"publisher":"JMIR Publications Inc.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMIR Res Protoc"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Older adults who are frail face significant barriers to physical activity, and innovative solutions such as synchronous telerehabilitation (STR) may provide a viable alternative to traditional face-to-face programs. However, less is known about its effectiveness compared to a face-to-face program.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to compare the effectiveness of an STR program versus a face-to-face physical therapy (FPT) program in the primary outcomes (lower body strength and cardiorespiratory fitness) and secondary outcomes (upper limb strength, dynamic balance, static balance, number of steps, functional status, and quality of life) in older adults who are frail.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a randomized, blinded, parallel-group controlled trial, all older adults who are frail and aged \u226560 years of both sexes from the Los Angeles Comprehensive Center for Older Adults will be invited to participate. A total of 58 older adults who are frail (aged \u226560 years) meeting the eligibility criteria will be randomly assigned to either an STR group (n=29, 50%) or an FPT group (n=29, 50%). Participants will engage in 1-hour multicomponent exercise sessions twice weekly for 12 weeks. The telerehabilitation group will participate via videoconferencing, supervised remotely by technical staff, while the face-to-face group will attend in-person sessions. Outcomes will include lower limb strength (sit-to-stand test), cardiorespiratory fitness (2-minute step test), upper limb strength (grip strength test), balance (Timed Up and Go, and single-leg stance), quality of life (36-item brief health survey), functional status (functional independence measure), and daily steps (pedometer).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Recruitment will be conducted from April to May 2025. The intervention will run from June to August 2025, follow-up assessments will be completed by September 2025, and data analysis will be finalized by December 2025. Manuscript drafting and submission are planned for March 2026. We hypothesize that STR will yield equal or superior improvements in both primary and secondary outcomes compared to FPT in older adults who are frail.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>STR is emerging as a viable and effective alternative to in-person physical therapy for older adults with frailty. This approach has the potential to improve physical condition and functional and quality of life indicators, overcoming geographical and logistical barriers and optimizing therapeutic resources.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov NCT06784245; https:\/\/clinicaltrials.gov\/study\/NCT06784245<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>International Registered Report Identifier (IRRID)<\/jats:title>\n                    <jats:p>PRR1-10.2196\/72318<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2196\/72318","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:00:10Z","timestamp":1753891210000},"page":"e72318","source":"Crossref","is-referenced-by-count":4,"title":["Effectiveness of Synchronous Telerehabilitation Versus Face-to-Face 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