{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:05:48Z","timestamp":1791360348137,"version":"4.3.1"},"reference-count":61,"publisher":"JMIR Publications Inc.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMIR Res Protoc"],"abstract":"\n Background<\/jats:title>\n Hypertension affects 31% of the global adult population. Artificial intelligence\u2013based chatbots may support self-management of hypertension and other chronic disorders. Chronic Disease Management Program (CHAMP) is a digital health intervention designed to support chronic disease self-management, comprising a patient-facing chatbot and an artificial intelligence\u2013augmented clinical decision support system linked to electronic medical records.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n This project aims to optimize the deployment of CHAMP across primary care centers by developing implementation strategies and pilot-testing their appropriateness and effectiveness.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We report 3 interlinked studies. Study 1 is a rapid evidence review to evaluate the factors influencing the implementation of mobile health and chatbot interventions in health care settings and the strategies and processes involved. We will follow the Cochrane Rapid Reviews Methods Group methodology and use the Consolidated Framework for Implementation Research and the unified theory of acceptance and use of technology frameworks to analyze the data. Study 2 is a formative, mixed methods study to inform the state of CHAMP deployment to date, the organizational structure of primary care centers, and the barriers and facilitators influencing the implementation and scale-up of CHAMP in primary care centers. We will interview members of the CHAMP development and initial implementation team, health care providers (HCPs), primary care centers\u2019 leadership, and patient users and nonusers of CHAMP; conduct 1-day on-site visits to primary care centers; and assess the readiness to change among HCPs using validated questionnaires. Study 3 involves the development of implementation strategies for the implementation of CHAMP in primary care centers. We will develop a process map informed by the findings of studies 1 and 2 to outline the patient journey; map the barriers and facilitators influencing the implementation of CHAMP; and develop a set of implementation strategies to effectively implement CHAMP using the Expert Recommendations for Implementing Change taxonomy to define the implementation strategies and the action, actor, context, target, and time framework to define the strategy implementation processes. In parallel, we will use evidence-based behavioral science to test variations of the chatbot\u2019s messages to increase patient engagement.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n To date, the evidence review protocol (study 1) has been registered on PROSPERO. We have completed title and abstract screening and are in the full-text screening phase. For study 2, we obtained ethics approval and conducted the semistructured interviews with HCPs, primary care centers\u2019 leadership, and members of the CHAMP development and initial implementation team. We are awaiting institutional review board approval to start the interviews with patients.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The study results will inform the further implementation and scale-up of CHAMP across primary care centers in Singapore. Successful implementation of digital health interventions to support self-management of chronic disorders may improve health care delivery without further straining health care systems.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n PROSPERO CRD42024613653; https:\/\/www.crd.york.ac.uk\/PROSPERO\/view\/CRD42024613653<\/jats:p>\n <\/jats:sec>\n \n International Registered Report Identifier (IRRID)<\/jats:title>\n DERR1-10.2196\/72942<\/jats:p>\n <\/jats:sec>","DOI":"10.2196\/72942","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:50:09Z","timestamp":1756993809000},"page":"e72942","source":"Crossref","is-referenced-by-count":3,"title":["Implementation of a Digital Health Intervention (CHAMP) for Self-Monitoring of Hypertension: Protocol for 3 Interlinked Implementation Studies"],"prefix":"10.2196","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3539-7207","authenticated-orcid":false,"given":"Laura","family":"Martinengo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2217-1467","authenticated-orcid":false,"given":"Ngoc Huong Lien","family":"Ha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6781-1049","authenticated-orcid":false,"given":"Eugene","family":"Tay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1017-6889","authenticated-orcid":false,"given":"Shao Chuen","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7560-8924","authenticated-orcid":false,"given":"Nick","family":"Sevdalis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1010","published-online":{"date-parts":[[2025,10,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00933-4"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-019-0244-2"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-025869"},{"key":"ref4","unstructured":"Global report on hypertension: the race against a silent killerWorld Health Organization20232025-10-03https:\/\/www.who.int\/publications\/i\/item\/9789240081062"},{"key":"ref5","unstructured":"Disease Policy and Strategy Division, Ministry of HealthHealth Analytics Division, Ministry of HealthNational Population Health Survey 2022 (household interview and health examination)Disease Policy and Strategy Division202309272024-04-17Republic of SingaporeMinistry of Healthhttps:\/\/www.moh.gov.sg\/resources-statistics\/reports\/national-population-health-survey-2022"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.160911"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1001737"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.24.2857"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/hjh.0b013e3283163caf"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpz182"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002389"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000803"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.31772"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-019-0916-0"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3109\/10641963.2013.764890"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2196\/34767"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000003793"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.2196\/52464"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab559"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.2196\/20346"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.2196\/20701"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.2196\/39649"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038\/s41746-023-00856-1"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2023.104494"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.2196\/40789"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1093\/ntr\/ntac281"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1177\/20552076231211634"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1093\/jamia\/ocy072"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1007\/s10916-025-02176-1"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.2196\/12887"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1055\/a-2035-5342"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1177\/2055207619871808"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-022-02512-2"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1177\/20552076211063012"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.2196\/11951"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.2196\/44688"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1038\/s41746-023-00899-4"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2020.10.007"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2022-070849"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38336.804167.47"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-016-0384-4"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n160"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1186\/1748-5908-4-50"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1186\/s13012-022-01245-0"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.2307\/30036540"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-13-117"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1080\/2159676x.2019.1704846"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-018-0594-7"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1177\/1525822x05279903"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1186\/1748-5908-9-7"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1186\/1748-5908-4-67"},{"key":"ref52","unstructured":"HartleySNThe readiness monitoring tool: investigating the psychometric evidence for group-level aggregation in two samplesUniversity of South Carolina20182025-10-03https:\/\/scholarcommons.sc.edu\/etd\/4821\/"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1002\/jcop.21698"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1186\/s13012-020-01041-8"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1186\/s13012-015-0295-0"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1186\/s13012-019-0951-x"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1111\/puar.12564"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1016\/j.joep.2011.10.009"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-025-04028-8"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1080\/10810730.2013.768727"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-023-16198-2"}],"container-title":["JMIR Research Protocols"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.researchprotocols.org\/2025\/1\/e72942","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T18:03:24Z","timestamp":1782842604000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.researchprotocols.org\/2025\/1\/e72942"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,17]]},"references-count":61,"URL":"https:\/\/doi.org\/10.2196\/72942","relation":{"has-preprint":[{"id-type":"doi","id":"10.2196\/preprints.72942","asserted-by":"object"}]},"ISSN":["1929-0748"],"issn-type":[{"value":"1929-0748","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,17]]}}}