{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T19:01:51Z","timestamp":1782846111785,"version":"3.54.5"},"reference-count":31,"publisher":"JMIR Publications Inc.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMIR Res Protoc"],"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Skin grafting is currently the gold standard for managing traumatic skin defects. However, split-thickness skin grafting, the most common technique, is challenging because it yields a limited amount of skin and creates a new wound at the healthy donor site. RECELL (Avita Medical), a noncultured skin cell suspension technique, yields healing outcomes with comparable duration and quality to skin grafting for burn trauma. Although RECELL is widely used for burn trauma, its use for severe traumatic skin defects is not yet prevalent in Japan.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n This study aims to evaluate the utility of the RECELL skin reconstruction technique in trauma cases involving significant skin defects. Specifically, the primary aim is to validate the efficacy of the RECELL skin reconstruction technique when combined with split-thickness mesh grafting in patients with significant posttraumatic skin defects, with a particular focus on wound closure and scar quality.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This prospective, single-center, open-label pilot study will enroll patients aged 16 years and older with traumatic limb skin defects \u2265160 cm\u00b2 and sufficient dermal-like tissue. Participants will undergo RECELL-assisted autologous skin grafting with mesh grafts under general anesthesia. Wound healing, scarring (Vancouver Scar Scale), and pain (visual analog scale) will be assessed up to 24 weeks postoperatively. The primary end point is \u226595% reepithelialization at postoperative day 14. Descriptive statistical analyses will be performed to evaluate outcomes and inform future randomized trials.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Patient recruitment began in April 2024 and is currently ongoing in our hospital. As of April 10, 2025, 10 patients had been screened, of whom 4 were enrolled. No adverse events or protocol deviations have been noted.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n This study aims to validate the utility of RECELL for skin defects resulting from trauma by assessing wound closure and scar formation, including adverse events, delayed healing, infection, and durability.<\/jats:p>\n <\/jats:sec>","DOI":"10.2196\/74159","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T19:40:10Z","timestamp":1764013210000},"page":"e74159-e74159","source":"Crossref","is-referenced-by-count":0,"title":["Utility of RECELL for Traumatic Skin Defects: Protocol for a Prospective, Single-Arm Pilot Study"],"prefix":"10.2196","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3908-3838","authenticated-orcid":false,"given":"Naoki","family":"Maegawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2780-9566","authenticated-orcid":false,"given":"Hironobu","family":"Konishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2352-1963","authenticated-orcid":false,"given":"Keisuke","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9072-9916","authenticated-orcid":false,"given":"Akinori","family":"Okuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3980-3904","authenticated-orcid":false,"given":"Hideki","family":"Asai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9645-3885","authenticated-orcid":false,"given":"Keita","family":"Miyazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3630-6135","authenticated-orcid":false,"given":"Yasuyuki","family":"Kawai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8135-8626","authenticated-orcid":false,"given":"Hidetada","family":"Fukushima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1010","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1097\/BOT.0000000000000605","article-title":"Split thickness skin graft to lower leg","volume":"30 Suppl 2","author":"Fuller","journal-title":"J Orthop Trauma"},{"issue":"1","key":"R2","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1097\/PRS.0000000000003927","article-title":"Muscle versus fasciocutaneous free flaps in lower extremity traumatic reconstruction: a multicenter outcomes analysis","volume":"141","author":"Cho","journal-title":"Plast Reconstr Surg"},{"issue":"1","key":"R3","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.oooo.2013.01.007","article-title":"Management of the radial forearm free flap donor site using a topically applied tissue expansion device","volume":"116","author":"Bonaparte","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"issue":"1","key":"R4","doi-asserted-by":"publisher","DOI":"10.1002\/micr.31126","article-title":"Comparison of the outcomes of split thickness skin graft versus thickness skin graft for closure of the radial forearm free flap donor site: a systematic review","volume":"44","author":"Mosquera","journal-title":"Microsurgery"},{"issue":"5","key":"R5","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1097\/00000637-199805000-00001","article-title":"Negative-pressure dressings as a bolster for skin grafts","volume":"40","author":"Blackburn","journal-title":"Ann Plast Surg"},{"issue":"5","key":"R6","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1111\/wrr.12840","article-title":"Course of scar quality of donor sites following split skin graft harvesting: comparison between patients and observers","volume":"28","author":"Legemate","journal-title":"Wound Repair Regen"},{"key":"R7","unstructured":"Instructions for use: RECELL\u00ae autologous cell harvesting device. 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