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Collaborative practice agreements (CPAs) between pharmacists and clinicians represent a promising strategy to improve PrEP accessibility through pharmacy-based services.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n The Collaborative Agreement\u2013based PrEP Using Pharmacies (CAP-UP) study aims to evaluate the development, implementation, and effectiveness of a CPA template and training resources to enhance pharmacy-based PrEP initiation and adherence in the Southeastern US.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n The CAP-UP study uses a hybrid type 1 effectiveness-implementation design guided by integrated implementation science frameworks. It includes three phases: (1) exploration, using online surveys and in-depth interviews to identify barriers and facilitators to CPA implementation; (2) preparation, developing and refining a CPA template and training resources; and (3) implementation, piloting the CPA template in 10 community pharmacies within high-HIV-prevalence neighborhoods.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The CAP-UP study was funded in October 2023 by the National Institutes of Health through the Center for AIDS Research (grant P30-AI050409-25S1) as an Ending the HIV Epidemic supplement. Recruitment launched in November 2023 and is actively ongoing, with 264 pharmacy staff having completed surveys as of January 2026. The study aims to recruit a total of 300 participants for surveys and conduct 68 in-depth interviews by February 2026.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Expanding HIV prevention services through community pharmacies represents a practical and impactful strategy for addressing inequities in HIV prevention that advances health equity. By leveraging implementation science frameworks, our study explores a novel approach to integrating HIV prevention services in pharmacies located in areas with high HIV prevalence. Findings from this work will contribute to the evidence base needed to optimize pharmacy-based PrEP delivery and support the national goal of Ending the HIV Epidemic in the US.<\/jats:p>\n <\/jats:sec>","DOI":"10.2196\/76058","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T06:40:07Z","timestamp":1773988807000},"page":"e76058-e76058","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of a Collaborative Practice Agreement Intervention to Improve Access to HIV Prevention Services in Southeastern US Pharmacies: Protocol for a Hybrid Type 1 Effectiveness-Implementation Study"],"prefix":"10.2196","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8283-7887","authenticated-orcid":false,"given":"Chante","family":"Hamilton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1406-3635","authenticated-orcid":false,"given":"Alexis","family":"Hudson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9471-5749","authenticated-orcid":false,"given":"Christina","family":"Chandra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6502-2986","authenticated-orcid":false,"given":"Seth","family":"Zissette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5381-0914","authenticated-orcid":false,"given":"Rachel","family":"Rothman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9970-7265","authenticated-orcid":false,"given":"Daniel I","family":"Alohan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6564-7513","authenticated-orcid":false,"given":"Donald G","family":"Klepser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7494-1450","authenticated-orcid":false,"given":"Alvan","family":"Quamina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3062-0384","authenticated-orcid":false,"given":"R Wayne","family":"Woodson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5052-1563","authenticated-orcid":false,"given":"David","family":"Holland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4859-6304","authenticated-orcid":false,"given":"Natalie D","family":"Crawford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1010","published-online":{"date-parts":[[2026,5,11]]},"reference":[{"key":"R1","unstructured":"Fast facts: HIV in the United States. 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