{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T19:03:26Z","timestamp":1782846206411,"version":"3.54.5"},"reference-count":49,"publisher":"JMIR Publications Inc.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMIR Cancer"],"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Clinical trials are important for all stages of the cancer control continuum, including cancer survivorship.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n The purpose of this study was to evaluate correlates of general clinical trial knowledge among US adult cancer survivors.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We conducted a cross-sectional analysis of the National Cancer Institute\u2019s 2021 Health Information National Trends Survey. Cancer survivors were recruited from 3 Surveillance, Epidemiology, and End Results registries: Iowa Cancer Registry, Greater Bay Area Cancer Registry, and New Mexico Tumor Registry. Data collection occurred from January 11 to August 20, 2021. Eligible participants had a cancer diagnosis prior to 2018. The primary outcome was self-reported knowledge of clinical trials, assessed by the question: \u201c\n How would you describe your level of knowledge about clinical trials?<\/jats:italic>\n \u201d Responses were dichotomized as knowing \u201ca lot\u201d or \u201ca little bit\u201d versus \u201cdon\u2019t know anything.\u201d Independent variables included sociodemographic characteristics, patient-centered communication, health information seeking (including watching health-related videos on YouTube), and confidence in obtaining cancer-related information. We used survey-weighted logistic regression to examine univariable and multivariable associations with clinical trial knowledge. A total of 2 a priori hypotheses were specified: (1) cancer survivors with a higher perceived quality of patient-centered communication would have greater knowledge of clinical trials than those with a lower perceived quality of patient-centered communication and (2) cancer survivors who were \u201ccompletely confident\u201d in their ability to obtain cancer-related information would have greater knowledge of clinical trials than those less confident. Odds ratios (ORs), 95% CIs, and\n P<\/jats:italic>\n values were estimated using SAS (version 9.4; SAS Institute Inc, Cary, NC, USA).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among cancer survivors (N=1207) included in the analysis, 269 (22.3%) reported that they did not know anything about clinical trials, while 938 (77.7%) reported knowing \u201ca lot\u201d or \u201ca little.\u201d Neither of the 2 a priori hypotheses was supported. In the multivariable weighted logistic regression model, greater knowledge of clinical trials was significantly associated with non-Hispanic White race compared with all other races (OR 2.55, 95% CI 1.59, 4.08;\n P<\/jats:italic>\n <.001), having a college degree compared with less than a college degree (OR 3.50, 95% CI 2.25, 5.46;\n P<\/jats:italic>\n <.001), seeking cancer information from any source (OR 3.04, 95% CI 2.10\u20104.40;\n P<\/jats:italic>\n <.001) compared with not, and ever watched health-related videos on YouTube (OR 2.71, 95% CI 1.49\u20104.94;\n P<\/jats:italic>\n =.002) compared with never watched. In contrast, female sex assigned at birth was associated with lower odds of clinical trial knowledge compared with male sex assigned at birth (OR 0.57, 95% CI 0.41\u20100.80;\n P<\/jats:italic>\n <.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Sociodemographic characteristics and health-seeking behaviors including watching health-related videos on YouTube were associated with clinical trial knowledge among cancer survivors. These findings highlight opportunities to leverage YouTube as a platform to promote clinical trial awareness and to strengthen survivors\u2019 cancer-specific information-seeking skills to improve access to clinical trial information.<\/jats:p>\n <\/jats:sec>","DOI":"10.2196\/76187","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T02:25:08Z","timestamp":1761531908000},"page":"e76187-e76187","source":"Crossref","is-referenced-by-count":0,"title":["Knowledge of Clinical Trials Among US Cancer Survivors: Cross-Sectional Study of HINTS-SEER Data"],"prefix":"10.2196","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1758-691X","authenticated-orcid":false,"given":"Aisha Tene","family":"Langford","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1709-3912","authenticated-orcid":false,"given":"Katrina Renee","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8187-2710","authenticated-orcid":false,"given":"Nancy","family":"Buderer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2157-3497","authenticated-orcid":false,"given":"Navreet","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1010","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmedr.2023.102564","article-title":"Racial and ethnic disparities in knowledge, attitudes, and invitation to participate in clinical trials among cancer survivors in the United States: an analysis of the 2020 U.S. HINTS","volume":"37","author":"Commaroto","journal-title":"Prev Med Rep"},{"key":"R2","unstructured":"About cancer clinical research. 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