{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T19:04:43Z","timestamp":1782846283995,"version":"3.54.5"},"reference-count":53,"publisher":"JMIR Publications Inc.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Internet Res"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec sec-type=\"background\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Early in the children\u2019s COVID-19 rollout in the United States, racial and ethnic vaccination rate disparities were evident. Based on COVID-19 communication literature and qualitative interviews with Hispanic parents, we developed a mobile phone\u2013delivered digital intervention to address factors associated with low vaccine confidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"objective\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We conducted a community-based randomized controlled trial of a digital intervention called MiVacunaLA\/MyShotLA to increase COVID-19 vaccine uptake among Hispanic children. The fully automated digital intervention was designed in collaboration with community organizations and linguistically and culturally tailored to meet the informational needs of Hispanic caregivers. The intervention focused on families with unvaccinated children 5 to 11 years old but was offered to families with any unvaccinated children 17 years or younger.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants were recruited with community organization partners and trained parent ambassadors via an open online screener. The 4-week intervention consisted of 3 SMS text messages with culturally and linguistically tailored educational information weekly. Intervention materials were delivered digitally through a closed online platform. Study team members were blinded. We used a difference-in-difference model with an intention-to-treat approach. The primary outcome was self-reported COVID-19 vaccine uptake among household children collected via online questionnaires. Secondary outcomes included COVID-19 vaccine knowledge, vaccine trust, and measures of participant engagement. We conducted a sensitivity analysis using the treatment-on-the-treated approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 254 participants completed the baseline survey (128 control and 126 intervention). The average participant age was 34 (SD 6.3) years with an average of 1.7 (SD 0.8) minors in the household, and among households, 62.2% (n=158) reported having children aged 5 to 11 years old. Most participants (n=207, 81.5%) reported English as their primary language. We found a statistically significant difference of 13.3% (95% CI 0.3%-26.4%;\n                      <jats:italic>P<\/jats:italic>\n                      =.04) points in self-reported vaccine uptake between intervention and control groups among caregivers of Hispanic children aged 5 to 11 years old. We also found a statistically significant point difference of 14.3% (95% CI 0%\u201023.7%;\n                      <jats:italic>P<\/jats:italic>\n                      =.003) between intervention and control groups in trust of governmental approval processes for the children\u2019s COVID-19 vaccine. Most participants reported that the weekly digital videos and educational information were \u201cvery\u201d (892\/1031, 86.5%) or \u201cextremely\u201d (888\/1019, 87.1%) useful.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MiVacunaLA demonstrates that a culturally tailored, community-based, mobile phone\u2013delivered vaccine educational intervention can increase COVID-19 vaccine uptake among Hispanic children and improve caregivers\u2019 trust in governmental vaccine processes. MiVacunaLA is innovative in its integration of community-informed design with a fully automated, mobile phone\u2013centric format and builds on prior literature by prospectively evaluating a culturally tailored, SMS text messaging\u2013linked web curriculum in a community setting. Findings provide evidence that scalable, low-cost, digital strategies can measurably improve trust and uptake in a population facing persistent vaccination gaps. Real-world implications include the portability and adaptability of this approach across diverse communities and settings to support timely, community-engaged vaccination efforts for broader applicability and scalability in public health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2196\/78103","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T08:55:07Z","timestamp":1765356907000},"page":"e78103-e78103","source":"Crossref","is-referenced-by-count":0,"title":["Digital Intervention (MiVacunaLA 2.0) to Promote COVID-19 Vaccine Acceptance Among Hispanic Children: Community-Based Randomized Controlled Trial"],"prefix":"10.2196","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3609-0645","authenticated-orcid":false,"given":"Luisa R","family":"Blanco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7676-3595","authenticated-orcid":false,"given":"Alexandra","family":"Klomhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9457-0562","authenticated-orcid":false,"given":"Rebecca","family":"Dudovitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6211-5590","authenticated-orcid":false,"given":"Denise","family":"Marquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5612-5582","authenticated-orcid":false,"given":"Ray","family":"Lopez-Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0174-023X","authenticated-orcid":false,"given":"Evelyn","family":"Aleman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5926-7286","authenticated-orcid":false,"given":"Bas","family":"Weerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3400-981X","authenticated-orcid":false,"given":"Michael","family":"Moldoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3071-0700","authenticated-orcid":false,"given":"Keith","family":"Norris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4886-7792","authenticated-orcid":false,"given":"Yelba","family":"Castellon-Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1010","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"issue":"5","key":"R1","doi-asserted-by":"publisher","first-page":"986","DOI":"10.3201\/eid2805.220166","article-title":"Disparities in first dose COVID-19 vaccination coverage among children 5-11 years of age, United States","volume":"28","author":"Murthy","journal-title":"Emerg Infect Dis"},{"key":"R2","unstructured":"COVID-19 vaccination coverage and intent for vaccination, children 6 months through 17 years, United States. 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