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However, there is a lack of evidence of the impact of health coaching apps on individuals with multimorbidity.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n This study aimed to assess the impact and acceptability of a health coaching app (the Holly Health [HH] app) on the subjective well-being (SWB) of adults with multimorbidity.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This study used an explanatory-sequential mixed methods design, with quantitative secondary data analysis in the first phase and qualitative interviews in the second phase. In the quantitative phase (n=565), pre- and post-SWB (Office for National Statistics' 4 personal well-being questions [ONS4]) scores from existing app users with multimorbidity were analyzed using Bayesian growth curve modeling to assess the impact of HH. In the qualitative phase (n=22), data were collected via semistructured interviews and analyzed using reflexive thematic analysis. Mechanisms of action that supported SWB were categorized using the Multi-Level Leisure Mechanisms Framework.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n There was a significant increase in life satisfaction (Coef.=0.71, 95% highest density interval [HDI] 0.52\u20100.89), worthwhileness (Coef.=0.62, 95% HDI 0.43\u20100.81), and happiness (Coef.=0.74, 95% HDI 0.54\u20100.92) and a decrease in anxiety (Coef.=\u22120.50, 95% HDI \u22120.74 to \u22120.25) before and after using the HH app. Overall, 8 acceptable app features activated 5 mechanisms of action, including behavioral, psychological, and social mechanisms. Three additional factors influenced the acceptability of the health coaching app: type of chronic condition, availability of time, and the use of other support tools.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The study demonstrates that health coaching apps could be effective and acceptable support tools for individuals with multimorbidity. 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