{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:55:58Z","timestamp":1790808958411,"version":"4.1.0"},"reference-count":106,"publisher":"JMIR Publications Inc.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Internet Res"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec sec-type=\"background\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cataracts are an eye condition characterized by high prevalence and blindness-inducing potential, and effective approaches are required for their early diagnosis, underscoring the clinical significance of this study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"objective\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to evaluate the performance of deep learning (DL) in cataract diagnosis and assess its potential as an effective tool for automated diagnosis, and compare the diagnostic accuracy of DL versus both machine learning and human experts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search was conducted in Web of Science, Embase, IEEE Xplore, PubMed, and Cochrane Library until April 1, 2025, for studies on image-based DL for cataract detection or clinical subtype classification. The included studies were assessed for the risk of bias (RoB) using Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2). Bivariate mixed effects models were used for data analyses, and publication bias was assessed by Deeks\u2019 funnel plots.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty-three studies were finally included. The quality assessment indicated a high or unclear RoB in the patient selection (34 studies) and index test (44 studies) domains. Meanwhile, in the reference standard domain, the risk of bias was high or unclear in only 2 studies. Image-based DL achieved a sensitivity of 96% (95% CI 0.95\u20100.97) and a specificity of 98% (0.96\u20100.98) for cataract detection, with an area under the ROC curve (AUC) of 0.99 (0.98\u20101.00). For cataract classification, the sensitivity and specificity of image-based DL were 94% (0.93\u20100.96) and 97% (0.96\u20100.98), respectively, with an AUC of 0.99 (0.98\u20100.99). Despite the strong overall performance, the model\u2019s generalization capability was challenged by its lower performance observed on independent external datasets (detection: sensitivity 87%, specificity 93%; classification: sensitivity 89%, specificity 90%), potentially attributable to domain shift between the training and validation data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Image-based DL has demonstrated high precision in the detection and classification of cataracts, showing potential advantages over traditional machine learning methods, though validation remains limited. Its performance falls within the range of reported accuracy of human experts, highlighting the high feasibility of automated diagnosis. However, validation data limitations, coupled with moderate-quality evidence and high heterogeneity, constrain the utility of DL in auxiliary diagnosis. The model\u2019s sensitivity dropped to 87% in external validation, restricting its generalization capability, so caution should be exercised in broad clinical implementation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2196\/78869","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:21:01Z","timestamp":1777494061000},"page":"e78869-e78869","source":"Crossref","is-referenced-by-count":1,"title":["Image-Based Deep Learning for Cataract Diagnosis: Systematic Review and Meta-Analysis"],"prefix":"10.2196","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5331-1060","authenticated-orcid":false,"given":"Ruixi","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8337-3341","authenticated-orcid":false,"given":"Hongyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9730-8225","authenticated-orcid":false,"given":"Chong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7062-9808","authenticated-orcid":false,"given":"Shuo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2839-1437","authenticated-orcid":false,"given":"Linhong","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5961-7560","authenticated-orcid":false,"given":"Dan","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1010","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"issue":"10374","key":"R1","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/S0140-6736(22)01839-6","article-title":"Cataracts","volume":"401","author":"Cicinelli","journal-title":"Lancet"},{"issue":"2","key":"R2","doi-asserted-by":"publisher","first-page":"e144","DOI":"10.1016\/S2214-109X(20)30489-7","article-title":"Causes of blindness and VISION impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the Right to Sight: an analysis for the Global Burden of Disease Study","volume":"9","author":"Steinmetz","journal-title":"Lancet Glob Health"},{"issue":"2","key":"R3","doi-asserted-by":"publisher","first-page":"e130","DOI":"10.1016\/S2214-109X(20)30425-3","article-title":"Trends in prevalence of blindness and distance and near vision impairment over 30 years: an analysis for the Global Burden of Disease Study","volume":"9","author":"Bourne","journal-title":"Lancet Glob Health"},{"key":"R4","doi-asserted-by":"crossref","unstructured":"Dawson-Squibb JJ Davids EL Viljoen M Rice K Stein DJ . 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