{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:45:35Z","timestamp":1792172735754,"version":"4.4.0"},"reference-count":34,"publisher":"JMIR Publications Inc.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMIR Cardio"],"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Surgical site infection (SSI) in patients with frailty undergoing myocardial revascularization is a major clinical challenge, and there is a gap in the literature related to this topic.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n This study aimed to identify perioperative variables associated with SSI in patients with frailty and prefrailty undergoing coronary artery bypass grafting within 30 days of the procedure.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This retrospective observational study included 467 patients with frailty or prefrailty aged 60 years and older who underwent coronary artery bypass grafting in 6 Brazilian centers between January 2018 and December 2024. Frailty was defined using the Fried criteria. SSI was defined as a wound with exposed tissue with positive culture requiring antibiotic treatment. Univariate and multivariate analyses were carried out.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The rate of SSI was 5.6% (26\/467). The New York Heart Association classification (\n P<\/jats:italic>\n =.02), Charlson Comorbidity Index (CCI;\n P<\/jats:italic>\n =.01), use of cardiopulmonary bypass (CPB;\n P<\/jats:italic>\n =.003), CPB time (\n P<\/jats:italic>\n =.02), total surgery time (\n P<\/jats:italic>\n <.001), occurrence of bleeding (\n P<\/jats:italic>\n =.04), mechanical ventilation time (\n P<\/jats:italic>\n =.001), length of hospital stay (\n P<\/jats:italic>\n <.001), intensive care unit stay (\n P<\/jats:italic>\n <.001), and need for reoperation (\n P<\/jats:italic>\n <.001) variables were associated with SSI in unadjusted comparisons. In the multivariate model, the CCI (odds ratio 1.58, 95% CI 1.25\u20101.99;\n P<\/jats:italic>\n <.001) and use of CPB (odds ratio 4.89, 95% CI 1.71\u201013.94;\n P<\/jats:italic>\n =.003) were independently associated with SSI.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The CCI and the use of CPB were independently associated with SSI.<\/jats:p>\n <\/jats:sec>","DOI":"10.2196\/79408","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T22:40:09Z","timestamp":1786574409000},"page":"e79408-e79408","source":"Crossref","is-referenced-by-count":0,"title":["Influence of Perioperative Variables on Surgical Site Infection in Patients With Frailty and Prefrailty Undergoing Coronary Artery Bypass Grafting: Retrospective Multicenter Study"],"prefix":"10.2196","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8710-4316","authenticated-orcid":false,"given":"Mauricio","family":"Guerrieri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1635-4984","authenticated-orcid":false,"given":"Omar","family":"Mejia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1352-2847","authenticated-orcid":false,"given":"Bianca","family":"Meneghini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0033-4141","authenticated-orcid":false,"given":"Natali","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2964-8587","authenticated-orcid":false,"given":"William","family":"Burato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5973-978X","authenticated-orcid":false,"given":"Maisa","family":"Barros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7517-4736","authenticated-orcid":false,"given":"Daniel","family":"Wernsbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7857-0228","authenticated-orcid":false,"given":"Lucas","family":"Bartelega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0112-8589","authenticated-orcid":false,"given":"Alexandre","family":"Hueb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6175-5595","authenticated-orcid":false,"given":"Fabio","family":"Jatene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1010","published-online":{"date-parts":[[2026,10,16]]},"reference":[{"key":"R1","unstructured":"DataBank | World development indicators. 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