{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T14:19:34Z","timestamp":1785161974106,"version":"3.55.0"},"reference-count":50,"publisher":"JMIR Publications Inc.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMIR Cancer"],"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Cancer survivors face long-term health challenges posttreatment. Physical activity (PA) can help manage cancer-related side effects and offer additional health benefits, yet up to 80% of survivors do not meet PA guidelines. Effective and translatable PA interventions are needed.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n This randomized trial assessed the feasibility, acceptability, and preliminary efficacy of a 12-week automated Internet program for increasing moderate-to-vigorous physical activity (MVPA) among cancer survivors. A secondary aim examined the effect of the intervention on physical and mental well-being.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Inactive (<60 min\/wk of PA) cancer survivors who completed cancer-directed treatment in the past 3\u201012 months or those on a stable maintenance treatment regimen were randomized to the Energize! Exercise Program or Newsletter control condition. The Energize! Program was fully automated and involved weekly behaviorally-based video lessons, homework assignments, exercise planning and reporting, and progressive MVPA goals (75 to 200 min\/wk). Algorithm-generated personalized feedback was provided based on PA goal attainment and homework completion. The newsletter group received bimonthly PA education newsletters (a total of 6). Assessments occurred at baseline, 3 months (postintervention), and 6 months (following a 3-month no-contact follow-up). Feasibility was assessed via enrollment and retention rates, acceptability was assessed via intervention engagement metrics and program satisfaction questionnaire, and MVPA was assessed via both self-report and accelerometer (min\/wk of total and \u201cbouted\u201d MVPA [accumulated in bouts \u226510 min]). Health-related outcomes (eg, quality of life, fatigue, psychological distress, psychological symptoms, and fear of cancer recurrence) were assessed via electronic questionnaires.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Forty-six adults aged 55.2 (SD 8.3) years, with BMI mean 33.0 (SD 7.6) kg\/m\u00b2; 42 (91.3%) female, and 37 (80.4%) non-Hispanic White enrolled in this trial. Feasibility metrics indicate that 69% (46\/67) of those who screened eligible were randomized and 6-month retention among randomized participants was 94% (43\/46). Acceptability was also high, as evidenced by the percentage of lessons viewed (mean 87.7%, SD 21.3%), exercise plans submitted (mean 82.6%, SD 25.8%), homework assignments completed (mean 77.2%, SD 25.2%), and weeks in which exercise minutes were logged (mean 85.9%, SD 22.1%). Program satisfaction ratings were higher in Energize (mean 5.8, SD 1.6; 1\u20107 scale) versus Newsletter (mean 3.2, SD 1.6;\n P<\/jats:italic>\n <.001). Energize! increased self-reported (92.7 min\/wk), bouted (35.4 min\/wk), and total (46.3 min\/wk) MVPA at 3 months (Cohen\n d<\/jats:italic>\n =0.74\u20100.94), and these changes were partially maintained at 6 months. Increases in MVPA were smaller among Newsletter participants (\n d<\/jats:italic>\n =0.28\u20100.47). Group differences in health-related outcomes were minimal and mixed, favoring Energize! over Newsletter for vitality (\n d<\/jats:italic>\n =0.63) and somatization (\n d<\/jats:italic>\n =0.76) at 3 months, and for depression (\n d<\/jats:italic>\n =0.59) and anxiety (\n d<\/jats:italic>\n =0.51) at 6 months.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The automated Energize! Program is feasible, acceptable, and associated with positive changes in MVPA, yet future studies are needed to improve MVPA long-term. Findings suggest that self-guided PA programs may be beneficial for increasing MVPA among cancer survivors.<\/jats:p>\n <\/jats:sec>","DOI":"10.2196\/79610","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T14:25:06Z","timestamp":1757514306000},"page":"e79610-e79610","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of a Translatable Web-Based Intervention for Increasing Physical Activity Among Cancer Survivors: Pilot Randomized Trial"],"prefix":"10.2196","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6807-9515","authenticated-orcid":false,"given":"Jessica L","family":"Unick","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4670-5440","authenticated-orcid":false,"given":"Christine","family":"Duffy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6541-9580","authenticated-orcid":false,"given":"Don","family":"Dizon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6467-5352","authenticated-orcid":false,"given":"Mary Ann","family":"Fenton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6742-1837","authenticated-orcid":false,"given":"Zihuan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3757-7860","authenticated-orcid":false,"given":"Katrina","family":"Oselinsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9817-8242","authenticated-orcid":false,"given":"Selene Y","family":"Tobin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0918-8252","authenticated-orcid":false,"given":"Rena R","family":"Wing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1010","published-online":{"date-parts":[[2025,10,2]]},"reference":[{"key":"R1","unstructured":"ACS annual report: cancer mortality continues to drop despite rising incidence in women; rates of new diagnoses under 65 higher in women than men. 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