{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T19:06:04Z","timestamp":1782846364089,"version":"3.54.5"},"reference-count":28,"publisher":"JMIR Publications Inc.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMIR Res Protoc"],"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Total hip arthroplasty is a highly successful procedure for treating hip arthritis, improving patients\u2019 pain, function, and quality of life (QoL). Scarce publications on total hip arthroplasty performance using Brazilian-manufactured materials report results comparable to those from other countries.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n The aim of this study is to compare the clinical, radiographic, functional, pain, and QoL outcomes of patients who underwent surgery with a national hybrid prosthesis (with femoral cementation) versus patients who underwent surgery with a national uncemented prosthesis.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This study is a single-center, single-surgeon, single-approach, pragmatic, double-blinded, and prospective randomized trial. A total of 120 patients will be enrolled and randomly allocated in a 1:1 ratio to 2 groups: the hybrid group and the uncemented group. The incidence of complications (during and after surgery) and the restoration of normal anatomical parameters on postoperative radiographs will be assessed using radiographic parameters. Participants\u2019 QoL, joint mobility, function, and satisfaction will be evaluated using the 12-Item Short Form Health Survey version 2 questionnaire, hip range of motion, the Harris Hip Score, and a numeric rating scale. Prosthesis survival will be analyzed using the annual revision surgery rate from 1 to 5 years, and up to 10 years.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The project did not receive external funding. Data collection began in October 2024 and is ongoing, with completion expected in December 2029. As of April 2025, 72 participants have been enrolled. Preliminary data analysis has been initiated and is ongoing. The first results are expected to be published in the first half of 2026.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n This study is a pragmatic clinical trial that uses blinding to evaluate national implants for both hybrid and uncemented hip arthroplasty. Successful completion of this study may provide clinical evidence on the performance of national implants and identify a preferred implant construct (hybrid or uncemented), if any, for hip replacement in Brazil.<\/jats:p>\n <\/jats:sec>","DOI":"10.2196\/79721","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T14:55:07Z","timestamp":1767797707000},"page":"e79721-e79721","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Uncemented and Hybrid Hip Arthroplasty: Protocol for a Brazilian Randomized Controlled Trial"],"prefix":"10.2196","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8394-6840","authenticated-orcid":false,"given":"Bruno Gon\u00e7alves Schroder e","family":"Souza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7701-3161","authenticated-orcid":false,"given":"Isabella Dias","family":"Lacerda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8193-8937","authenticated-orcid":false,"given":"Matheus Malta","family":"Vasconcelos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1104-5294","authenticated-orcid":false,"given":"Nath\u00e1lia Lacerda","family":"Furtado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1902-1103","authenticated-orcid":false,"given":"Julia Machado","family":"Vieira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6318-5213","authenticated-orcid":false,"given":"Iasmim Sand Ferreira de","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7131-3090","authenticated-orcid":false,"given":"Marco Ant\u00f4nio Per\u00edgolo","family":"Magalh\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6948-273X","authenticated-orcid":false,"given":"Leon\u00e3 Aparecido Homem do","family":"Amaral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0414-4709","authenticated-orcid":false,"given":"Luiz Guilherme Vidal","family":"Assad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4748-5063","authenticated-orcid":false,"given":"Carlos Henrique Cavaglieri Silveira","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5155-1596","authenticated-orcid":false,"given":"Carolina","family":"Tsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7691-2127","authenticated-orcid":false,"given":"Valdeci Manoel de","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1010","published-online":{"date-parts":[[2026,3,16]]},"reference":[{"issue":"9597","key":"R1","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1016\/S0140-6736(07)60457-7","article-title":"The operation of the century: total hip replacement","volume":"370","author":"Learmonth","journal-title":"Lancet"},{"issue":"7","key":"R2","first-page":"1745","volume":"27","author":"Jones","journal-title":"J Rheumatol"},{"issue":"10172","key":"R3","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/S0140-6736(18)31665-9","article-title":"How long does a hip replacement last? 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