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While ePROs are increasingly used in adult populations, their use in children, especially when combined with gamification, remains underexplored.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n This MyPal4Kids study aimed to assess the feasibility, acceptability, and user engagement of a digital health platform that integrates ePROs and a serious game, designed for pediatric oncology patients aged 6\u201017 years and their caregivers.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A multicenter observational feasibility study was conducted between December 2020 and September 2022 at 3 clinical sites in Germany and the Czech Republic. A total of 83 children and adolescents with cancer, their parent or legal guardian, as well as 10 health care professionals (HCPs) participated. Primary outcomes included platform acceptability and engagement, assessed through recruitment, participation, and attrition rates, adherence, and usability ratings. Secondary outcomes focused on the feasibility of ePRO-based data capture and the perceived impact on HCP workflows and communication. A mixed methods design was used, combining in-app data and surveys with qualitative insights from focus groups.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The recruitment rate was 55%, with an attrition rate of 18%. Usability was rated positively, with most users finding the platform intuitive. Sustained engagement declined over time, particularly among older children who found the serious game insufficiently engaging. Adherence varied by age group and HCP involvement. Participants reported increased motivation when symptom reports were acknowledged by HCPs, although the impact on communication was perceived inconsistently.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The developed platform shows potential for use in clinical care and research. However, maintaining long-term engagement remains a challenge. Tailoring content to different age groups and strengthening feedback mechanisms from HCPs are critical for improving the user experience. Successful implementation in routine clinical practice will require integration into existing workflows and digital infrastructure, along with ongoing user-driven development.<\/jats:p>\n <\/jats:sec>","DOI":"10.2196\/80718","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T16:52:21Z","timestamp":1786467141000},"page":"e80718-e80718","source":"Crossref","is-referenced-by-count":0,"title":["Feasibility of Implementing an Electronic Patient-Reported Outcome-Based Digital Health Platform in Pediatric Oncology and Palliative Care: Insights From the MyPal4Kids Multicenter Observational 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