{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:43:26Z","timestamp":1785545006356,"version":"3.56.0"},"reference-count":61,"publisher":"JMIR Publications Inc.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMIR Serious Games"],"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Subthreshold depression (StD) increases the risk of progression to major depressive disorder. Although exercise can reduce depressive symptoms, adherence remains challenging. Exergames on platforms such as Nintendo Switch may improve motivation and participation in physical activity; however, evidence for efficacy in StD is limited.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n This study aims to evaluate the effects of a Nintendo Switch\u2013based exergaming intervention on depressive symptoms, anxiety, and sleep quality, and to explore participant experiences among adults with StD.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This sequential explanatory mixed methods study comprised a randomized controlled trial followed by semistructured interviews. Eighty-four adults with StD were randomized using computer-generated permuted blocks with concealed allocation to an intervention group (IG; n=42), which received an 8-week Nintendo Switch\u2013based exergame program (2\u20103 sessions\/week, 50\u201060 minutes\/session), or a control group (CG; n=42), which continued usual activities. Outcome assessors and data analysts were blinded. Depressive symptoms, anxiety, and sleep quality were assessed at baseline (T0), postintervention (T1, Week 8), one-month follow-up (T2, Week 12), and 2-month follow-up (T3, Week 16). Generalized estimating equations (GEE) were used to analyze longitudinal changes and time\u00d7group interactions under the intention-to-treat principle. Semistructured interviews were conducted with a purposive subsample of IG participants (n=17) at T1 and analyzed using thematic analysis.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Eighty-four participants were randomized; 81 completed the postintervention assessment, with 3 out of 42 (7.1%) CG participants lost to follow-up at T1. Baseline characteristics were similar across groups (mean age 23.07, SD 1.45 years; 70\/84, 83.3% female). Compared with CG, the IG showed significantly greater reductions in depressive symptoms at all time points (T1:\n \u03b2<\/jats:italic>\n =\u22124.07, 95% CI \u22125.84 to \u22122.30;\n P<\/jats:italic>\n <.001; T2:\n \u03b2<\/jats:italic>\n =\u22124.29, 95% CI \u22126.14 to \u22122.43;\n P<\/jats:italic>\n <.001; T3:\n \u03b2<\/jats:italic>\n =\u22123.81, 95% CI \u22125.54 to \u22122.08;\n P<\/jats:italic>\n <.001), along with significant improvements in sleep quality (T1:\n \u03b2<\/jats:italic>\n =\u22122.98, 95% CI \u22124.55 to \u22121.40;\n P<\/jats:italic>\n <.001; T2:\n \u03b2<\/jats:italic>\n =\u22122.19, 95% CI \u22123.58 to \u22120.80;\n P<\/jats:italic>\n =.002; T3:\n \u03b2<\/jats:italic>\n =\u22122.45, 95% CI \u22123.81 to \u22121.09;\n P<\/jats:italic>\n <.001). Anxiety also improved significantly at T1 (\n \u03b2<\/jats:italic>\n =\u22122.60, 95% CI \u22124.70 to \u22120.50;\n P<\/jats:italic>\n =.02) and T3 (\n \u03b2<\/jats:italic>\n =\u22122.38, 95% CI \u22124.62 to \u22120.14;\n P<\/jats:italic>\n =.04). Group\u00d7time interactions were significant for depressive symptoms (Wald\n \u03c7<\/jats:italic>\n 2<\/jats:sup>\n 3<\/jats:sub>\n =28.18;\n P<\/jats:italic>\n =.001) and sleep quality (Wald\n \u03c7<\/jats:italic>\n 2<\/jats:sup>\n 3<\/jats:sub>\n =23.21;\n P<\/jats:italic>\n <.001), confirming sustained intervention effects. Qualitative findings supported these results, highlighting immersive engagement, perceived psychophysiological benefits, and adherence facilitators. No adverse events were reported.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n A Nintendo Switch\u2013based exergaming intervention was associated with improvements in depressive symptoms, anxiety, and sleep quality in adults with StD. Using mixed methods design, this study provides evidence integrating effectiveness and participant experience, extending prior research focused on other populations or quantitative outcomes. These findings suggest that commercially available exergaming platforms may serve as accessible, engaging tools for early mental health support in real-world settings.<\/jats:p>\n <\/jats:sec>","DOI":"10.2196\/80937","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T17:43:26Z","timestamp":1780681406000},"page":"e80937-e80937","source":"Crossref","is-referenced-by-count":0,"title":["Nintendo Switch\u2013Based Exergaming for Subthreshold Depression: Mixed Methods Randomized Controlled Trial"],"prefix":"10.2196","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9356-685X","authenticated-orcid":false,"given":"Kexin","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5112-4253","authenticated-orcid":false,"given":"Lei","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8259-0678","authenticated-orcid":false,"given":"Ariadna","family":"Albajara S\u00e1enz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3255-6062","authenticated-orcid":false,"given":"Rendong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6209-5068","authenticated-orcid":false,"given":"Yongliang","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4201-6591","authenticated-orcid":false,"given":"Yong","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9556-9053","authenticated-orcid":false,"given":"Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1010","published-online":{"date-parts":[[2026,6,5]]},"reference":[{"issue":"7","key":"R1","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1017\/S0033291712002309","article-title":"Subsyndromal depression in the United States: prevalence, course, and risk for incident psychiatric outcomes","volume":"43","author":"Pietrzak","journal-title":"Psychol Med"},{"issue":"5","key":"R2","doi-asserted-by":"publisher","first-page":"292","DOI":"10.3969\/j.issn.1002-0829.2012.05.009","article-title":"Understanding subthreshold depression","volume":"24","author":"Juruena","journal-title":"Shanghai Arch Psychiatry"},{"issue":"3","key":"R3","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1192\/bjp.bp.108.054239","article-title":"Minor depression during adolescence and mental health outcomes during adulthood","volume":"195","author":"Johnson","journal-title":"Br J Psychiatry"},{"issue":"4","key":"R4","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/s00127-004-0745-5","article-title":"Subsyndromal depression: prevalence, use of health services and quality of life in an Australian population","volume":"39","author":"Goldney","journal-title":"Soc Psychiatry Psychiatr Epidemiol"},{"issue":"2","key":"R5","doi-asserted-by":"publisher","first-page":"231","DOI":"10.13935\/j.cnki.sjzx.160224","article-title":"A clinical study on the treatment of depression in college students with auricular pressure pill combined with Taijiquan","volume":"11","author":"Xu","journal-title":"World J Integr Tradit West Med"},{"key":"R6","doi-asserted-by":"crossref","unstructured":"Association AP. Diagnostic and Statistical Manual of Mental Disorders. American Psychiatric Association; 2013:591-643. [doi: 10.1176\/appi.books.9780890425596]","DOI":"10.1176\/appi.books.9780890425596"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2016.00215","article-title":"Serious games and gamification for mental health: current status and promising directions","volume":"7","author":"Fleming","journal-title":"Front Psychiatry"},{"issue":"3","key":"R8","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1089\/g4h.2020.0180","article-title":"Effects of Nintendo Ring Fit Adventure exergame on pain and psychological factors in patients with chronic low back pain","volume":"10","author":"Sato","journal-title":"Games Health J"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.2196\/45243","article-title":"Active video game interventions targeting physical activity behaviors: systematic review and meta-analysis","volume":"25","author":"Moller","journal-title":"J Med Internet Res"},{"issue":"12","key":"R10","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1177\/1359105320909866","article-title":"Does exergaming drive future physical activity and sport intentions?","volume":"26","author":"Soltani","journal-title":"J Health Psychol"},{"issue":"3","key":"R11","doi-asserted-by":"publisher","first-page":"100472","DOI":"10.1016\/j.cpcardiol.2019.100472","article-title":"Exergaming and virtual reality for health: implications for cardiac rehabilitation","volume":"46","author":"Bond","journal-title":"Curr Probl Cardiol"},{"issue":"2","key":"R12","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1080\/10447318.2018.1441253","article-title":"Older adults\u2019 physical activity and exergames: a systematic review","volume":"35","author":"Kappen","journal-title":"Int J Hum Comput Interact"},{"issue":"1","key":"R13","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1038\/nm.4246","article-title":"Resting-state connectivity biomarkers define neurophysiological subtypes of depression","volume":"23","author":"Drysdale","journal-title":"Nat Med"},{"issue":"10","key":"R14","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1111\/ped.12942","article-title":"Effects of Nintendo Wii-Fit video games on balance in children with mild cerebral palsy","volume":"58","author":"Tarakci","journal-title":"Pediatr Int"},{"issue":"5","key":"R15","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1089\/g4h.2018.0066","article-title":"Effects of exercise training combined with virtual reality in functionality and health-related quality of life of patients on hemodialysis","volume":"8","author":"Maynard","journal-title":"Games Health J"},{"issue":"1","key":"R16","doi-asserted-by":"publisher","DOI":"10.2196\/35040","article-title":"Effect of the Nintendo Ring Fit Adventure exergame on running completion time and psychological factors among university students engaging in distance learning during the COVID-19 pandemic: randomized controlled trial","volume":"10","author":"Wu","journal-title":"JMIR Serious Games"},{"issue":"5","key":"R17","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1016\/j.jamda.2021.01.076","article-title":"Effectiveness of Nintendo Wii and physical therapy in functionality, balance, and daily activities in chronic stroke patients","volume":"22","author":"Marques-Sule","journal-title":"J Am Med Dir Assoc"},{"issue":"3","key":"R18","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1097\/JGP.0b013e3181c534b5","article-title":"Exergames for subsyndromal depression in older adults: a pilot study of a novel intervention","volume":"18","author":"Rosenberg","journal-title":"Am J Geriatr Psychiatry"},{"issue":"12","key":"R19","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1080\/13607863.2017.1385722","article-title":"Exergames vs. traditional exercise: investigating the influencing mechanism of platform effect on subthreshold depression among older adults","volume":"22","author":"Li","journal-title":"Aging Ment Health"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2024.102665","article-title":"Exergame-based rehabilitation for cancer patients undergoing abdominal surgery: effects on pain, anxiety, depression, and fatigue - a pilot study","volume":"72","author":"Alves","journal-title":"Eur J Oncol Nurs"},{"issue":"3","key":"R21","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1007\/s00415-023-12043-z","article-title":"Efficacy of the use of video games on mood, anxiety and depression in stroke patients: preliminary findings of a randomised controlled trial","volume":"271","author":"Bl\u00e1zquez-Gonz\u00e1lez","journal-title":"J Neurol"},{"issue":"3","key":"R22","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1177\/0269215514542638","article-title":"Participant and caregiver experience of the Nintendo Wii Sports","volume":"29","author":"Wingham","journal-title":"Clin Rehabil"},{"issue":"5","key":"R23","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1080\/11038128.2016.1267259","article-title":"Elderly people\u2019s perceptions of using Wii sports bowling - a qualitative study","volume":"24","author":"Gl\u00e4nnfjord","journal-title":"Scand J Occup Ther"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2024.1390806","article-title":"The effectiveness of an exergame intervention for college students with subthreshold depression: protocol for a mixed methods study","volume":"12","author":"Huang","journal-title":"Front Public Health"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2024-081123","article-title":"CONSORT 2025 statement: updated guideline for reporting randomised trials","volume":"389","author":"Hopewell","journal-title":"BMJ"},{"issue":"4","key":"R26","doi-asserted-by":"publisher","DOI":"10.2196\/jmir.1923","article-title":"CONSORT-EHEALTH: improving and standardizing evaluation reports of Web-based and mobile health interventions","volume":"13","author":"Eysenbach","journal-title":"J Med Internet Res"},{"issue":"1","key":"R27","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1037\/amp0000151","article-title":"Journal article reporting standards for qualitative primary, qualitative meta-analytic, and mixed methods research in psychology: the APA Publications and Communications Board task force report","volume":"73","author":"Levitt","journal-title":"Am Psychol"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychsport.2022.102266","article-title":"Exergame-based exercise training for depressive symptoms in adults: a systematic review and meta-analysis","volume":"63","author":"Huang","journal-title":"Psychol Sport Exerc"},{"issue":"3","key":"R29","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1097\/YCO.0b013e3280fb2720","article-title":"The development of the diagnostic and statistical manual of mental disorders version V substance use disorders section: establishing the research framework","volume":"20","author":"Saunders","journal-title":"Curr Opin Psychiatry"},{"issue":"3","key":"R30","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1177\/014662167700100306","article-title":"The CES-D Scale: a self-report depression scale for research in the general population","volume":"1","author":"Radloff","journal-title":"Appl Psychol Meas"},{"issue":"2","key":"R31","doi-asserted-by":"publisher","first-page":"139","DOI":"10.3969\/j.issn.1000-6729.2010.02.015","article-title":"Establishment of the national urban norm of depression scale in floating center","volume":"24","author":"Zhang","journal-title":"Chin Ment Health J"},{"issue":"9","key":"R32","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1046\/j.1525-1497.2001.016009606.x","article-title":"The PHQ-9: validity of a brief depression severity measure","volume":"16","author":"Kroenke","journal-title":"J Gen Intern Med"},{"issue":"6","key":"R33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0270095","article-title":"Pittsburgh Sleep Quality Index (PSQI) responses are modulated by total sleep time and wake after sleep onset in healthy older adults","volume":"17","author":"Zitser","journal-title":"PLoS One"},{"issue":"3","key":"R34","doi-asserted-by":"publisher","first-page":"260","DOI":"10.3969\/j.issn.1671-8348.2014.03.002","article-title":"Reliability and validity analysis of Pittsburgh sleep quality index","volume":"43","author":"Lu","journal-title":"Chongqing Medicine"},{"key":"R35","unstructured":"Blair J Czaja RF Blair Edward A . Designing Surveys: A Guide to Decisions and Procedures. 3rd ed. SAGE Publications; 2014:1-424. ISBN: 978-1-4129-9734-8"},{"issue":"1","key":"R36","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1093\/biomet\/73.1.13","article-title":"Longitudinal data analysis using generalized linear models","volume":"73","author":"Liang","journal-title":"Biometrika"},{"issue":"1","key":"R37","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1111\/j.1365-2648.2007.04569.x","article-title":"The qualitative content analysis process","volume":"62","author":"Elo","journal-title":"J Adv Nurs"},{"issue":"9","key":"R38","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1177\/1049732305276687","article-title":"Three approaches to qualitative content analysis","volume":"15","author":"Hsieh","journal-title":"Qual Health Res"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2016.02.023","article-title":"Exercise as a treatment for depression: a meta-analysis adjusting for publication bias","volume":"77","author":"Schuch","journal-title":"J Psychiatr Res"},{"key":"R40","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2019.09.040","article-title":"Physical activity and depression: towards understanding the antidepressant mechanisms of physical activity","volume":"107","author":"Kandola","journal-title":"Neurosci Biobehav Rev"},{"issue":"585","key":"R41","doi-asserted-by":"publisher","first-page":"149","DOI":"10.3399\/bjgp11X567054","article-title":"Patients\u2019 views of physical activity as treatment for depression: a qualitative study","volume":"61","author":"Searle","journal-title":"Br J Gen Pract"},{"key":"R42","doi-asserted-by":"crossref","unstructured":"Curran J Ekers D McMillan D Houghton S . Behavioural activation. In: Dryden W , editor. Cognitive Behaviour Therapies. SAGE Publications Ltd; 2012:236-260. [doi: 10.4135\/9781446288368.n11] ISBN: 9780857021182","DOI":"10.4135\/9781446288368.n11"},{"issue":"8","key":"R43","doi-asserted-by":"publisher","DOI":"10.3390\/bs14080713","article-title":"Association between the behavioral activation mechanism and depression severity: focusing on avoidance patterns of university students","volume":"14","author":"Takagaki","journal-title":"Behav Sci (Basel)"},{"issue":"1","key":"R44","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1089\/g4h.2014.0072","article-title":"Cultivating engagement and enjoyment in exergames using feedback, challenge, and rewards","volume":"4","author":"Lyons","journal-title":"Games Health J"},{"issue":"3","key":"R45","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1093\/clipsy.8.3.255","article-title":"Behavioral activation treatment for depression: returning to contextual roots","volume":"8","author":"Jacobson","journal-title":"Clin Psychol Rev"},{"issue":"9","key":"R46","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1089\/cyber.2017.0183","article-title":"The psychological effects of playing exergames: a systematic review","volume":"20","author":"Lee","journal-title":"Cyberpsychol Behav Soc Netw"},{"issue":"12","key":"R47","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1016\/j.brat.2005.11.014","article-title":"Self-efficacy and social behavior","volume":"44","author":"Rodebaugh","journal-title":"Behav Res Ther"},{"key":"R48","doi-asserted-by":"publisher","DOI":"10.1016\/j.chb.2016.12.033","article-title":"How gamification motivates: an experimental study of the effects of specific game design elements on psychological need satisfaction","volume":"69","author":"Sailer","journal-title":"Comput Human Behav"},{"issue":"1","key":"R49","doi-asserted-by":"publisher","DOI":"10.1186\/s12966-023-01493-3","article-title":"Effects of habit formation interventions on physical activity habit strength: meta-analysis and meta-regression","volume":"20","author":"Ma","journal-title":"Int J Behav Nutr Phys Act"},{"issue":"42","key":"R50","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/1748-5908-6-42","article-title":"The behaviour change wheel: a new method for characterising and designing behaviour change interventions","volume":"6","author":"Michie","journal-title":"Implement Sci"},{"issue":"10","key":"R51","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1016\/s0277-9536(99)00390-1","article-title":"Constructions of masculinity and their influence on men\u2019s well-being: a theory of gender and health","volume":"50","author":"Courtenay","journal-title":"Soc Sci Med"},{"issue":"11","key":"R52","doi-asserted-by":"publisher","first-page":"46","DOI":"10.3969\/j.issn.1002-1701.2021.11.022","article-title":"The mediating effect of positive psychological capital on rumination and depression of medical students during \"examination month","author":"Yan","journal-title":"China High Med Educ"},{"issue":"12","key":"R53","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1177\/0961203311412098","article-title":"Using Wii Fit to reduce fatigue among African American women with systemic lupus erythematosus: a pilot study","volume":"20","author":"Yuen","journal-title":"Lupus (Los Angel)"},{"issue":"7","key":"R54","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1038\/nrn3524","article-title":"Uncertainty and anticipation in anxiety: an integrated neurobiological and psychological perspective","volume":"14","author":"Grupe","journal-title":"Nat Rev Neurosci"},{"issue":"41","key":"R55","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000040084","article-title":"A review of exercise interventions for reducing anxiety symptoms: insights and implications","volume":"103","author":"Ewuzie","journal-title":"Medicine (Baltimore)"},{"issue":"6","key":"R56","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1089\/g4h.2019.0077","article-title":"Investigating the feasibility of exergame on sleep and emotion among university students","volume":"9","author":"Wan Yunus","journal-title":"Games Health J"},{"issue":"3","key":"R57","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004691.pub2","article-title":"Exercise in prevention and treatment of anxiety and depression among children and young people","volume":"2006","author":"Larun","journal-title":"Cochrane Database Syst Rev"},{"issue":"3","key":"R58","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.jshs.2014.01.001","article-title":"The effects of exercise on self-rated sleep among adults with chronic sleep complaints","volume":"4","author":"Erlacher","journal-title":"J Sport Health Sci"},{"issue":"1","key":"R59","doi-asserted-by":"publisher","first-page":"107","DOI":"10.3233\/NRE-192748","article-title":"The effects of aerobic exercise on sleep quality measures and sleep-related biomarkers in individuals with multiple sclerosis: a pilot randomised controlled trial","volume":"45","author":"Al-Sharman","journal-title":"NeuroRehabilitation"},{"key":"R60","doi-asserted-by":"publisher","DOI":"10.1155\/jobe\/4164477","article-title":"Efficacy of interventions to promote exercise adherence in people with overweight or obesity: a systematic review","volume":"2025","author":"Rodrigues","journal-title":"J Obes"},{"issue":"7259","key":"R61","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1136\/bmj.321.7259.504","article-title":"Statistics notes: blinding in clinical trials and other studies","volume":"321","author":"Day","journal-title":"BMJ"}],"container-title":["JMIR Serious Games"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/games.jmir.org\/2026\/1\/e80937","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T22:26:36Z","timestamp":1785536796000},"score":1,"resource":{"primary":{"URL":"https:\/\/games.jmir.org\/2026\/1\/e80937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,5]]},"references-count":61,"URL":"https:\/\/doi.org\/10.2196\/80937","relation":{},"ISSN":["2291-9279"],"issn-type":[{"value":"2291-9279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,5]]},"article-number":"v14i7e80937"}}