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To meet these challenges, this paper explores the transformative potential of agentic AI systems to drive Healthcare 5.0 in urology to create a more equitable, efficient, and proactive care system. We examine how AI can advance the quintuple aim of health care: enhancing patient experience, improving population health, reducing costs, increasing provider satisfaction, and promoting health equity. The paper introduces the concept of a suite of specialized AI agents, rooted in both currently in use and developing AI applications, that work collaboratively to support providers, patients, and health care administrators across the continuum of care. These agents not only improve efficiency, streamline workflows, and augment clinical reasoning, but also enable scalable, virtual-first care delivery systems. We articulate our view of the future urology patient journey, illustrating how AI agents can transform each step of the process to provide an improved, seamless experience for patients and providers while maintaining human-centered, personalized care. Finally, we outline critical future directions, such as data interoperability, regulatory frameworks, and inclusive design principles, to ensure that AI technologies are deployed safely, equitably, and in line with ethical regulations. Through the strategic implementation of agentic AI, we view the future of men\u2019s health urology as a model for innovation, driving better outcomes for patients and sustainable, meaningful care for providers.<\/jats:p>","DOI":"10.2196\/81314","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T14:55:08Z","timestamp":1779202508000},"page":"e81314-e81314","source":"Crossref","is-referenced-by-count":0,"title":["Shaping the Future of Men\u2019s Health: How AI Could Be a Transformative Tool for Better Patient Outcomes and Provider Efficiency"],"prefix":"10.2196","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4071-2928","authenticated-orcid":false,"given":"Bryce","family":"Bisset","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7376-0321","authenticated-orcid":false,"given":"Vasanth","family":"Kainkaryam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7548-6979","authenticated-orcid":false,"given":"Shawn","family":"Marhamati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5564-4418","authenticated-orcid":false,"given":"Amin","family":"Moradi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2679-5772","authenticated-orcid":false,"given":"Reza","family":"Amin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3503-6014","authenticated-orcid":false,"given":"Justin","family":"Houman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1010","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"issue":"4","key":"R1","doi-asserted-by":"publisher","first-page":"78","DOI":"10.4103\/jwas.jwas_59_23","article-title":"The burden of urologic diseases in a tertiary hospital in South-eastern Nigeria: a three-year review","volume":"13","author":"Okeke","journal-title":"J West Afr Coll Surg"},{"issue":"1","key":"R2","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.ucl.2008.08.004","article-title":"The demographic burden of urologic diseases in America","volume":"36","author":"Miller","journal-title":"Urol Clin North Am"},{"key":"R3","unstructured":"Cleveland clinic survey reveals men\u2019s top health concerns as they age. 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