{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T19:07:16Z","timestamp":1782846436097,"version":"3.54.5"},"reference-count":67,"publisher":"JMIR Publications Inc.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMIR Pediatr Parent"],"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Protracted bacterial bronchitis (PBB) is a leading cause of chronic wet cough in children. Misdiagnosis and inadequate treatment may lead to the progression of diseases.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n The objective of this paper was to analyze factors influencing the cough duration prior to the diagnosis and assess health-related quality of life in children with PBB.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Children diagnosed with PBB in the Qilu Hospital of Shandong University from November 2021 to November 2022 were included in this study. Clinical data were collected; parents completed the Parent-Proxy Cough-Specific Quality of Life (PC-QOL) questionnaire and the simplified Cough Symptom Score. Children aged 6 years and older completed the Leicester Cough Questionnaire in Mandarin-Chinese (LCQ-MC).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n As of November 2022, we enrolled 88 patients. Place of residence (B=9.35, 95% CI 0.36-18.35;\n P<\/jats:italic>\n =.04) and rest status during the coughing episode (B=7.87, 95% CI 0.36-15.38;\n P<\/jats:italic>\n =.04) were significantly associated with cough duration prior to the diagnosis. PC-QOL scores (physical: mean 3.10, SD 1.36; psychological: mean 3.32, SD 1.57; social: mean 3.67, SD 1.53; total: mean 10.09, SD 4.21) showed physical-social differences (\n t<\/jats:italic>\n 174<\/jats:sub>\n =\u22122.58,\n P<\/jats:italic>\n =.01). PC-QOL posttreatment scores were significantly higher than pretreatment scores (physical:\n t<\/jats:italic>\n 18<\/jats:sub>\n =\u20136.05,\n P<\/jats:italic>\n <.001; psychological:\n t<\/jats:italic>\n 18<\/jats:sub>\n =\u20134.42,\n P<\/jats:italic>\n <.001; social:\n t<\/jats:italic>\n 18<\/jats:sub>\n =\u22124.79,\n P<\/jats:italic>\n <.001; total:\n t<\/jats:italic>\n 18<\/jats:sub>\n =\u20135.25,\n P<\/jats:italic>\n <.001). However, the scores of each PC-QOL domain were significantly lower than those of the LCQ-MC (physical:\n t<\/jats:italic>\n 34<\/jats:sub>\n =8.31,\n P<\/jats:italic>\n <.001; psychological:\n t<\/jats:italic>\n 34<\/jats:sub>\n =6.58,\n P<\/jats:italic>\n <.001; social:\n t<\/jats:italic>\n 34<\/jats:sub>\n =5.09,\n P<\/jats:italic>\n <.001; total:\n t<\/jats:italic>\n 34<\/jats:sub>\n =8.11,\n P<\/jats:italic>\n <.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Place of residence and rest status during the coughing episode were significantly associated with cough duration prior to the diagnosis\n .<\/jats:bold>\n Furthermore, PBB significantly reduces quality of life in physical, psychological, and social aspects.\n <\/jats:p>\n 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