{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T17:24:57Z","timestamp":1787851497452,"version":"build-2784847793"},"reference-count":54,"publisher":"JMIR Publications Inc.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMIR Mhealth Uhealth"],"abstract":"\n Background<\/jats:title>\n Poststroke cognitive impairment (PSCI) is a common and disabling complication after stroke; however, early screening remains challenging due to limited access to neuropsychological testing and the high cost of neuroimaging. Portable, tablet-based eye-tracking technology may offer a scalable, low-cost solution for early PSCI detection.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n This study aimed to evaluate the clinical utility of a tablet-based, AI-driven eye-tracking system for early screening of PSCI at 3 months after acute ischemic stroke. We sought to quantify oculomotor-cognitive associations and develop a practical nomogram for individualized risk prediction.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We prospectively enrolled 142 hospitalized patients with acute cerebral infarction between May 2023 and October 2024, of whom 122 completed the 3-month follow-up and were included in the final analysis, along with 20 healthy community-dwelling controls. All patients underwent tablet-based eye tracking (visual paired comparison and antisaccade tasks) during the acute phase, as well as baseline and 3-month neuropsychological assessments. PSCI was defined using validated cutoffs. Multivariable logistic regression was used to identify independent predictors, and a nomogram was constructed. Internal validation was performed using bootstrap resampling (1000 samples).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n At 3 months, out of 122 patients, 47 (38.5%) met PSCI criteria. Compared with patients with non-PSCI (n=75), patients with PSCI showed significantly prolonged correct saccade latency (median 322.96, IQR 209.45-445.59 ms vs 194.55, IQR 141.50-299.75 ms; Z=\u22124.03, P<.001), increased uncorrected error rate (median 30.00%, IQR 15.00%-42.00% vs 5.00%, IQR 0.00%-28.00%; Z=\u22124.24, P<.001), and reduced novelty preference ratio (median 1.44, IQR 0.97-1.70 vs 2.12, IQR 1.27-4.56; Z=\u22123.44, P=.001). Multivariable analysis identified 4 independent predictors of 3-month PSCI: older age (odds ratio [OR] 1.067 per year, 95% CI 1.009\u20101.129; P=.02), lower education level (OR 0.841 per year, 95% CI 0.708\u20100.999; P=.049), higher NIHSS (National Institutes of Health Stroke Scale) scores (OR 1.557 per point, 95% CI 1.075\u20102.256; P=.02), and prolonged correct saccade latency (OR 1.004 per ms, 95% CI 1.000\u20101.007; P=.04). A nomogram incorporating these 4 factors achieved good discriminative performance (area under the receiver operating characteristic curve 0.86, 95% CI 0.793\u20100.927) with satisfactory calibration.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Age, education, admission NIHSS, and correct saccade latency were identified as possible independent predictors of 3-month PSCI in this cohort. The tablet-based eye-tracking system, when combined with clinical variables, may represent a feasible approach for early PSCI screening. A nomogram based on these variables demonstrated high accuracy and potential clinical utility for early PSCI identification. This approach may facilitate early identification of high-risk patients and enable timely, personalized interventions in resource-limited settings.<\/jats:p>\n <\/jats:sec>","DOI":"10.2196\/83194","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T20:46:49Z","timestamp":1786049209000},"page":"e83194","source":"Crossref","is-referenced-by-count":0,"title":["Utility of Tablet-Based Eye Tracking for Early Screening of Poststroke Cognitive Impairment: Diagnostic Cohort Study"],"prefix":"10.2196","volume":"14","author":[{"given":"Boxu","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronghui","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junli","family":"Zhen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1010","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanwpc.2023.100687"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.033807"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.122.319951"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1177\/17474930241238637"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1184830"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00060-0"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1177\/17474930241246156"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1080\/23279095.2022.2155521"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/HRP.0000000000000255"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.2196\/76084"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2025.104363"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-024-02882-9"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-025-01884-7"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2196\/60766"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1109\/RBME.2021.3066072"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcad049"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-017-0910-5"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13478"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.871432"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13517"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1126\/science.adr3675"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2024.02.017"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2022.3227015"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2025.1692719"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-20200-9"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12081678"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-08048-5"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14288"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.70238"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2025.1671477"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000211"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-022-02133-9"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-025-13146-5"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.031611"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-023-01289-4"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1111\/phn.13503"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2023.122805"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1080\/13607863.2018.1501663"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2023.107354"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.123.042507"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.018417"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2422331122"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1016\/j.cophys.2020.04.006"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.3390\/vision7020038"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-vision-100720-125029"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-012-9420-z"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2023.1197567"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1142\/S0129065715500173"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.05.026"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad389"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.105460"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-7568(23)00217-9"},{"key":"r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