{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:26:12Z","timestamp":1790144772095,"version":"4.0.1"},"reference-count":38,"publisher":"JMIR Publications Inc.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMIR Perioper Med"],"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Open appendectomy is commonly performed under either general or spinal anesthesia. Postoperative quality of recovery, a multidimensional patient-centered measure of outcomes after surgery, is affected by the choice of anesthesia technique.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n The objective of our study was to compare the effects of general and spinal anesthesia on the immediate postoperative quality of recovery in adults undergoing open appendectomy.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In this prospective cohort study, 74 patients were assigned to either the general (n=37) or the spinal anesthesia (n=37) groups. The primary outcome was the total Quality of Recovery-15 score measured 24 hours postoperatively. Secondary outcomes included postoperative pain scores, analgesic consumption, incidence of postoperative nausea and vomiting, time to first oral intake, time to first ambulation, and length of hospital stay. Intergroup comparisons were performed using the chi-square test, Fisher exact test, independent\n t<\/jats:italic>\n test, or Mann-Whitney\n U<\/jats:italic>\n test, as appropriate.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Patients in the spinal anesthesia group had significantly higher Quality of Recovery-15 scores than those in the general anesthesia group (\n P=.<\/jats:italic>\n 001). They also exhibited lower pain scores at 1, 2, 6, and 12 hours postoperatively (\n P<.<\/jats:italic>\n 001), reduced consumption of diclofenac and tramadol, and a decreased incidence of postoperative nausea and vomiting (\n P<.<\/jats:italic>\n 001). The time to first mobilization, time to first oral intake, and length of hospital stay were also significantly lower in the spinal anesthesia group (\n P<.<\/jats:italic>\n 001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Spinal anesthesia is the preferred anesthesia technique for patients undergoing open appendectomy. It may provide improved postoperative recovery, with lower pain scores and improved analgesia. It may also reduce the need for additional analgesics, decrease the incidence of nausea and vomiting, and improve intrahospital patient recovery trajectories.<\/jats:p>\n <\/jats:sec>","DOI":"10.2196\/86273","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T20:52:34Z","timestamp":1782420754000},"page":"e86273-e86273","source":"Crossref","is-referenced-by-count":1,"title":["Comparing the Quality of Patient Recovery After Open Appendectomy Under General Versus Spinal Anesthesia: Prospective Cohort Study"],"prefix":"10.2196","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8401-309X","authenticated-orcid":false,"given":"Negesse Zurbachew","family":"Gobezie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0462-8299","authenticated-orcid":false,"given":"Temesgen Birlie","family":"Asmare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5881-1285","authenticated-orcid":false,"given":"Kumlachew Geta","family":"Belete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3584-4545","authenticated-orcid":false,"given":"Gezahagn Demsu","family":"Gedefaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9158-2506","authenticated-orcid":false,"given":"Biruk","family":"Demissie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8452-3436","authenticated-orcid":false,"given":"Abere Gebru","family":"Abuhay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7649-2830","authenticated-orcid":false,"given":"Belayneh Jejaw","family":"Abate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3608-8725","authenticated-orcid":false,"given":"Birhanu Mengist","family":"Munie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1522-7905","authenticated-orcid":false,"given":"Wubet Tazeb","family":"Wondie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7827-1416","authenticated-orcid":false,"given":"Habtie Bantider","family":"Wubet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1010","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"issue":"1","key":"R1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-023-02678-7","article-title":"The global, regional, and national burden of appendicitis in 204 countries and territories, 1990-2019: a systematic analysis from the Global Burden of Disease Study 2019","volume":"23","author":"Guan","journal-title":"BMC Gastroenterol"},{"issue":"22","key":"R2","doi-asserted-by":"publisher","first-page":"2299","DOI":"10.1001\/jama.2021.20502","article-title":"Diagnosis and management of acute appendicitis in adults: a review","volume":"326","author":"Moris","journal-title":"JAMA"},{"issue":"2","key":"R3","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1097\/SLA.0000000000002188","article-title":"The global incidence of appendicitis: a systematic review of population-based studies","volume":"266","author":"Ferris","journal-title":"Ann Surg"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijans.2021.100343","article-title":"Acute appendicitis in Ethiopia: a systematic review and meta-analysis","volume":"15","author":"Adu","journal-title":"Int J Afr Nurs Sci"},{"issue":"4","key":"R5","doi-asserted-by":"publisher","first-page":"208","DOI":"10.4174\/astr.2017.92.4.208","article-title":"Combined spinal-epidural anesthesia in laparoscopic appendectomy: a prospective feasibility study","volume":"92","author":"Uzman","journal-title":"Ann Surg Treat Res"},{"issue":"4","key":"R6","doi-asserted-by":"publisher","first-page":"669","DOI":"10.62713\/aic.3415","article-title":"Effect of intraspinal anesthesia on postoperative recovery in elderly patients with acute appendicitis: a retrospective study","volume":"95","author":"Sun","journal-title":"Ann Ital Chir"},{"issue":"11","key":"R7","doi-asserted-by":"publisher","first-page":"3295","DOI":"10.1007\/s00268-021-05978-9","article-title":"General versus neuraxial anesthesia for appendectomy: a multicenter international study","volume":"45","author":"El Moheb","journal-title":"World J Surg"},{"issue":"2","key":"R8","doi-asserted-by":"publisher","first-page":"148","DOI":"10.5114\/wiitm.2018.72684","article-title":"Spinal\/epidural block as an alternative to general anesthesia for laparoscopic appendectomy: a prospective randomized clinical study","volume":"13","author":"Erdem","journal-title":"Wideochir Inne Tech Maloinwazyjne"},{"issue":"4","key":"R9","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.51253\/pafmj.v73i4.9481","article-title":"Comparison of hemodynamic stability of patients undergoing appendectomy under spinal anesthesia versus blend of ketamine and midazolam with spinal anesthesia","volume":"73","author":"Kayani","journal-title":"PAFMJ"},{"issue":"5","key":"R10","doi-asserted-by":"publisher","first-page":"414","DOI":"10.18229\/kocatepetip.835963","article-title":"Comparison of bupivacaine\u2013fentanyl and bupivacaine-alfentanil used intrathecally in laparoscopic appendectomy surgery","volume":"22","author":"Balc\u0131","journal-title":"Kocatepe T\u0131p Dergisi"},{"issue":"5","key":"R11","doi-asserted-by":"publisher","first-page":"15","DOI":"10.55735\/hjprs.v4i5.287","article-title":"Postoperative complications of anaesthesia following appendectomy: complications of anaesthesia following appendectomy","volume":"4","author":"Bilal","journal-title":"Heal J Physiother Rehabil Sci"},{"issue":"4","key":"R12","doi-asserted-by":"publisher","first-page":"246","DOI":"10.4097\/kjae.2014.67.4.246","article-title":"Laparoscopic appendectomy under spinal anesthesia with dexmedetomidine infusion","volume":"67","author":"Jun","journal-title":"Korean J Anesthesiol"},{"issue":"4","key":"R13","first-page":"1402","volume":"11","author":"Latif","journal-title":"Pak J Med Health Sci"},{"issue":"2","key":"R14","doi-asserted-by":"publisher","first-page":"e69","DOI":"10.1055\/s-0041-1725933","article-title":"Open appendicectomy under spinal anesthesia-a valuable alternative during COVID-19","volume":"7","author":"Mai","journal-title":"Surg J (N Y)"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.35248\/2475-3181.7.178","article-title":"Comparison between spinal anesthesia vs general anesthesia in patients undergoing open appendectomy for acute appendicitis, a retrospective study","volume":"7","author":"Gabriel","journal-title":"J Hepatol Gastroint Dis"},{"issue":"3","key":"R16","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.36347\/sjams.2014.v02i03.053","article-title":"A clinical study of comparison between general anesthesia and spinal anesthesia for lower abdominal laparoscopic surgeries","volume":"2","author":"Gurudatta","journal-title":"Sch J Appl Med Sci"},{"issue":"2","key":"R17","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.bja.2024.04.044","article-title":"Impact of spinal or epidural anaesthesia on perioperative outcomes in adult noncardiac surgery: a narrative review of recent evidence","volume":"133","author":"Hewson","journal-title":"Br J Anaesth"},{"issue":"3","key":"R18","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.bjane.2021.01.013","article-title":"Effect of anesthetic technique on the quality of anesthesia recovery for abdominal histerectomy: a cross-observational study","volume":"71","author":"de Carli","journal-title":"Braz J Anesthesiol"},{"issue":"6","key":"R19","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1016\/j.bja.2022.03.009","article-title":"Measurement of quality of recovery after surgery using the 15-item quality of recovery scale: a systematic review and meta-analysis","volume":"128","author":"Myles","journal-title":"Br J Anaesth"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2022.110685","article-title":"Quality of recovery in the perioperative setting: a narrative review","volume":"78","author":"Wessels","journal-title":"J Clin Anesth"},{"key":"R21","doi-asserted-by":"crossref","unstructured":"Bowyer A Royse CF . Defining postoperative quality of recovery. In: Stuart-Smith K Stuart-Smith K , editors. Perioperative Medicine \u2013 Current Controversies. Springer International Publishing; 2016:87-107. [doi: 10.1007\/978-3-319-28821-5_5] ISBN: 9783319288215","DOI":"10.1007\/978-3-319-28821-5_5"},{"issue":"3-4","key":"R22","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.bpa.2018.07.002","article-title":"Defining quality of recovery \u2013 what is important to patients?","volume":"32","author":"Borrell-Vega","journal-title":"Best Pract Res Clin Anaesthesiol"},{"issue":"6","key":"R23","doi-asserted-by":"publisher","first-page":"e210","DOI":"10.1016\/j.bja.2021.03.008","article-title":"Postoperative quality of recovery measurements as endpoints in comparative anaesthesia studies: a systematic review","volume":"126","author":"L\u00e9ger","journal-title":"Br J Anaesth"},{"issue":"2","key":"R24","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1007\/s12630-015-0508-7","article-title":"The importance of postoperative quality of recovery: influences, assessment, and clinical and prognostic implications","volume":"63","author":"Bowyer","journal-title":"Can J Anaesth"},{"issue":"4","key":"R25","doi-asserted-by":"publisher","DOI":"10.4172\/2155-6148.1000713","article-title":"Comparative study between general and spinal anaesthesia in laparoscopic appendectomy","volume":"8","author":"Mokhtar Mehanna","journal-title":"J Anesth Clin Res"},{"issue":"1","key":"R26","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-025-03252-2","article-title":"Comparison of combined spinal-epidural versus general anesthesia with epidural catheter on postoperative quality of recovery after abdominal hysterectomy: a prospective observational study","volume":"25","author":"Taflan","journal-title":"BMC Anesthesiol"},{"issue":"7","key":"R27","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1007\/s12630-018-1101-7","article-title":"Bromage motor blockade score \u2013 a score that has lasted more than a lifetime","volume":"65","author":"Craig","journal-title":"Can J Anaesth"},{"issue":"1","key":"R28","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.bja.2017.11.013","article-title":"Systematic review of the QoR-15 score, a patient- reported outcome measure measuring quality of recovery after surgery and anaesthesia","volume":"120","author":"Kleif","journal-title":"Br J Anaesth"},{"issue":"6","key":"R29","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1213\/ANE.0b013e3182334d8b","article-title":"The effect of neuraxial versus general anesthesia techniques on postoperative quality of recovery and analgesia after abdominal hysterectomy: a prospective, randomized, controlled trial","volume":"113","author":"Catro-Alves","journal-title":"Anesth Analg"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcot.2020.11.017","article-title":"Comparative outcome analysis of spinal anesthesia versus general anesthesia in lumbar fusion surgery","volume":"13","author":"Sekerak","journal-title":"J Clin Orthop Trauma"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S426570","article-title":"Correlation between pain intensity and quality of recovery after video-assisted thoracic surgery for lung cancer resection","volume":"16","author":"Yoon","journal-title":"J Pain Res"},{"issue":"2","key":"R32","doi-asserted-by":"publisher","first-page":"73","DOI":"10.30699\/jogcr.3.2.73","article-title":"Comparing spinal and general anesthesia in terms of postoperative pain in patients undergoing hysterectomy","volume":"3","author":"Hosseinzadeh Zorofchi","journal-title":"J Obstet Gynecol Cancer Res"},{"issue":"4","key":"R33","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.jopan.2015.01.018","article-title":"Postoperative management of the physiological effects of spinal anesthesia","volume":"31","author":"O\u2019Neill","journal-title":"J Perianesth Nurs"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S370327","article-title":"The minimal clinically important differences as well as statistical differences of main endpoints are important in comparing postoperative benefits of different analgesic modalities [letter]","volume":"16","author":"Tian","journal-title":"Drug Des Devel Ther"},{"issue":"5","key":"R35","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1016\/j.bja.2021.01.021","article-title":"Minimal clinically important differences in randomised clinical trials on pain management after total hip and knee arthroplasty: a systematic review","volume":"126","author":"Laigaard","journal-title":"Br J Anaesth"},{"issue":"3","key":"R36","doi-asserted-by":"publisher","first-page":"388","DOI":"10.4103\/0259-1162.179310","article-title":"Postoperative nausea and vomiting: a simple yet complex problem","volume":"10","author":"Shaikh","journal-title":"Anesth Essays Res"},{"issue":"1","key":"R37","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s12871-016-0207-0","article-title":"Higher occurrence of nausea and vomiting after total hip arthroplasty using general versus spinal anesthesia: an observational study","volume":"16","author":"Sansonnens","journal-title":"BMC Anesthesiol"},{"issue":"1","key":"R38","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-025-03604-7","article-title":"Comparative analysis of spinal anesthesia versus general anesthesia in single-port access laparoscopic adnexal surgery: a propensity score matching study","volume":"25","author":"Eoh","journal-title":"BMC Womens Health"}],"container-title":["JMIR Perioperative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/periop.jmir.org\/2026\/1\/e86273","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T22:25:33Z","timestamp":1785536733000},"score":1,"resource":{"primary":{"URL":"https:\/\/periop.jmir.org\/2026\/1\/e86273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,25]]},"references-count":38,"URL":"https:\/\/doi.org\/10.2196\/86273","relation":{},"ISSN":["2561-9128"],"issn-type":[{"value":"2561-9128","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,25]]},"article-number":"v9i1e86273"}}