{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:44:03Z","timestamp":1785545043770,"version":"3.56.0"},"reference-count":9,"publisher":"JMIR Publications Inc.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMIR Dermatol"],"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Fractional radio frequency microneedling (FRM) is an effective nonsurgical facelift modality supported by growing clinical evidence. While generally well tolerated, postprocedural erythema, pain, swelling, and bruising typically last up to 7 days. Other serious complications include prolonged swelling, infection, persistent grid mark, burns, and hypo- or hyperpigmentation. Recombinant human collagen has demonstrated potent wound-healing and anti-inflammatory properties, which could be harnessed for post-FRM recovery.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To date, there is a lack of published studies evaluating the use of topical agents to improve postprocedural recovery following FRM. This case report describes the early experience of using topical recombinant collagen post FRM for nonsurgical facelift.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Two 40-year-old female patients with Fitzpatrick skin type IV underwent FRM for nonsurgical facelift. The procedure was performed with standard energy settings. Immediately post procedure, topical recombinant collagen was applied to the treated areas. Either clinical photography or cross-polarized imaging was used to objectively capture the changes in facial erythema and swelling.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Both cases demonstrated a marked reduction of erythema and inflammation within 1 to 2 hours after application of topical recombinant collagen. These observations appeared earlier compared to the typical timeframe of 1 to 3 days. No adverse events were reported.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Topical recombinant collagen application post FRM was associated with an early reduction of skin erythema and inflammation.<\/jats:p>\n <\/jats:sec>","DOI":"10.2196\/86892","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T15:25:09Z","timestamp":1778167509000},"page":"e86892-e86892","source":"Crossref","is-referenced-by-count":0,"title":["Topical Recombinant Collagen Following Fractional Radio Frequency Microneedling for Nonsurgical Facelift: Case Report"],"prefix":"10.2196","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8382-5262","authenticated-orcid":false,"given":"Thien-Chong Marcus","family":"Wong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5012-0105","authenticated-orcid":false,"given":"Yizhi","family":"Ong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1010","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"issue":"6","key":"R1","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1097\/DSS.0000000000002972","article-title":"Radiofrequency microneedling: a comprehensive and critical review","volume":"47","author":"Tan","journal-title":"Dermatol Surg"},{"issue":"8","key":"R2","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000002862","article-title":"Multimodal radiofrequency application for lower face and neck laxity","volume":"8","author":"Dayan","journal-title":"Plast Reconstr Surg Glob Open"},{"issue":"7","key":"R3","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.1111\/jocd.16361","article-title":"Correction of age-related changes in the skin at the dermal and subdermal level using radiofrequency macroneedling therapy","volume":"23","author":"Flegontova","journal-title":"J Cosmet Dermatol"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1093\/asjof\/ojad100","article-title":"Radiofrequency microneedling: technology, devices, and indications in the modern plastic surgery practice","volume":"5","author":"Shauly","journal-title":"Aesthet Surg J Open Forum"},{"issue":"5","key":"R5","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering8050063","article-title":"Collagen in wound healing","volume":"8","author":"Mathew-Steiner","journal-title":"Bioengineering (Basel)"},{"issue":"8","key":"R6","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1002\/bip.22486","article-title":"Review collagen-based biomaterials for wound healing","volume":"101","author":"Chattopadhyay","journal-title":"Biopolymers"},{"issue":"9","key":"R7","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1080\/00914037.2020.1740991","article-title":"Natural collagen bioscaffolds for skin tissue engineering strategies in burns: a critical review","volume":"70","author":"Sundar","journal-title":"Int J Polymeric Mater Polymeric Biomater"},{"issue":"3","key":"R8","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1016\/j.burns.2020.01.006","article-title":"A recombinant human collagen hydrogel for the treatment of partial-thickness burns: a prospective, self-controlled clinical study","volume":"47","author":"Ben","journal-title":"Burns"},{"issue":"22","key":"R9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s42825-025-00203-y","article-title":"Recombinant human collagen injection ameliorates skin photoaging via immunoregulation and collagen production","volume":"7","author":"Hu","journal-title":"Collagen Leather"}],"container-title":["JMIR Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/derma.jmir.org\/2026\/1\/e86892","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T22:25:23Z","timestamp":1785536723000},"score":1,"resource":{"primary":{"URL":"https:\/\/derma.jmir.org\/2026\/1\/e86892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,29]]},"references-count":9,"URL":"https:\/\/doi.org\/10.2196\/86892","relation":{},"ISSN":["2562-0959"],"issn-type":[{"value":"2562-0959","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,29]]},"article-number":"v9i6e86892"}}