{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T17:47:45Z","timestamp":1782841665300,"version":"3.54.5"},"reference-count":23,"publisher":"JMIR Publications Inc.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMIR Pediatr Parent"],"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Patients with mucopolysaccharidosis (MPS) appear to have an increased risk of developing dental disease.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n This study aimed to evaluate the status of dental caries and dental anomalies among Chinese patients with different types of MPS.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This retrospective study analyzed a consecutive cohort of 102 pediatric patients with MPS who visited the Department of Stomatology at the Capital Center for Children\u2019s Health between August 2010 and August 2025. Eligible patients were defined as those with a confirmed diagnosis of MPS who were aged \u226414 years at the time of their dental visit and had complete dental examination records available. Dental caries and anomalies were assessed through clinical records and radiographic data.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Dental caries were observed in 55.9% (57\/102) of patients, and no statistically significant difference was observed across the MPS subtypes (\n P<\/jats:italic>\n =.72). Deep dentinal caries (d4-6mft) were observed in 40.2% (41\/102) of the participants and contributed most to the total decayed, missing, and filled teeth index score. The overall prevalence of dental anomalies was 32.4% (33\/102), with a statistically significant difference among MPS subtypes (\n P<\/jats:italic>\n =.005). Patients with MPS type IV had a significantly higher risk of dental anomalies compared to those with MPS type II (odds ratio 6.32, 95% CI 1.55\u201028.28;\n P<\/jats:italic>\n =.01), after adjusting for age and gender.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The prevalence of dental anomalies differed significantly across MPS subtypes, while that of dental caries did not. These findings emphasize the need for early, targeted preventive care and tailored dental interventions to improve oral health outcomes in this population.<\/jats:p>\n <\/jats:sec>","DOI":"10.2196\/87430","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:42:02Z","timestamp":1777916522000},"page":"e87430-e87430","source":"Crossref","is-referenced-by-count":0,"title":["Dental Health in Pediatric Patients With Different Types of Mucopolysaccharidosis: Retrospective Cross-Sectional Study"],"prefix":"10.2196","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7115-9169","authenticated-orcid":false,"given":"Mengxing","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5683-9786","authenticated-orcid":false,"given":"Rong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4429-7981","authenticated-orcid":false,"given":"Tian","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6621-2292","authenticated-orcid":false,"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1010","published-online":{"date-parts":[[2026,5,4]]},"reference":[{"issue":"7","key":"R1","doi-asserted-by":"publisher","first-page":"2249","DOI":"10.4103\/ijo.IJO_425_22","article-title":"Mucopolysaccharidosis: a broad review","volume":"70","author":"Nagpal","journal-title":"Indian J Ophthalmol"},{"issue":"4","key":"R2","doi-asserted-by":"publisher","first-page":"443","DOI":"10.4103\/tjo.TJO-D-23-00137","article-title":"Mucopolysaccharidosis","volume":"13","author":"Bhakthaganesh","journal-title":"Taiwan J Ophthalmol"},{"issue":"1","key":"R3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5582\/irdr.2020.01011","article-title":"A basic understanding of mucopolysaccharidosis: incidence, clinical features, diagnosis, and management","volume":"9","author":"Zhou","journal-title":"Intractable Rare Dis Res"},{"issue":"1","key":"R4","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-022-02285-x","article-title":"The landscape of mucopolysaccharidosis in Southern and Eastern European countries: a survey from 19 specialistic centers","volume":"17","author":"Tylki-Szyma\u0144ska","journal-title":"Orphanet J Rare Dis"},{"issue":"2","key":"R5","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11020273","article-title":"Epidemiology of mucopolysaccharidoses update","volume":"11","author":"\u00c7elik","journal-title":"Diagnostics (Basel)"},{"issue":"4","key":"R6","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/jhg.2015.155","article-title":"Demographic characteristics and distribution of lysosomal storage disorder subtypes in Eastern China","volume":"61","author":"Chen","journal-title":"J Hum Genet"},{"issue":"4","key":"R7","first-page":"332","volume":"42","author":"Hp","journal-title":"P R Health Sci J"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1590\/1678-7757-2020-0978","article-title":"Dental and maxillomandibular incidental findings in panoramic radiography among individuals with mucopolysaccharidosis: a cross-sectional study","volume":"29","author":"Carneiro","journal-title":"J Appl Oral Sci"},{"issue":"3","key":"R9","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1002\/ccr3.3885","article-title":"Mucopolysaccharidosis (MPS): review of the literature and case series of five pediatric dental patients","volume":"9","author":"Hirst","journal-title":"Clin Case Rep"},{"issue":"6","key":"R10","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1002\/jmd2.12331","article-title":"Orofacial abnormalities in mucopolysaccharidosis and mucolipidosis type II and III: a systematic review","volume":"63","author":"de Bode","journal-title":"JIMD Rep"},{"issue":"1","key":"R11","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13010075","article-title":"Mucopolysaccharidosis: what pediatric rheumatologists and orthopedics need to know","volume":"13","author":"Costi","journal-title":"Diagnostics (Basel)"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2020.115729","article-title":"Hip disease in mucopolysaccharidoses and mucolipidoses: a review of mechanisms, interventions and future perspectives","volume":"143","author":"Oussoren","journal-title":"Bone"},{"issue":"4","key":"R13","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1007\/s00431-019-03330-x","article-title":"Growth impairment and limited range of joint motion in children should raise suspicion of an attenuated form of mucopolysaccharidosis: expert opinion","volume":"178","author":"Guffon","journal-title":"Eur J Pediatr"},{"issue":"Suppl 2","key":"R14","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-018-0550-5","article-title":"Mucopolysaccharidoses: early diagnostic signs in infants and children","volume":"44","author":"Galimberti","journal-title":"Ital J Pediatr"},{"issue":"4","key":"R15","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21041517","article-title":"Mucopolysaccharidosis IVA: diagnosis, treatment, and management","volume":"21","author":"Sawamoto","journal-title":"Int J Mol Sci"},{"issue":"1","key":"R16","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s00784-017-2100-8","article-title":"Evaluation of oral manifestations of patients with mucopolysaccharidosis IV and VI: clinical and imaging study","volume":"22","author":"de Almeida-Barros","journal-title":"Clin Oral Investig"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1007\/8904_2011_46","article-title":"The oral health needs of children, adolescents and young adults affected by a mucopolysaccharide disorder","volume":"2","author":"James","journal-title":"JIMD Rep"},{"issue":"2","key":"R18","doi-asserted-by":"publisher","first-page":"93","DOI":"10.5005\/jp-journals-10005-1089","article-title":"International caries detection and assessment system (ICDAS): a new concept","volume":"4","author":"Gugnani","journal-title":"Int J Clin Pediatr Dent"},{"issue":"11","key":"R19","first-page":"2050","volume":"48","author":"Moradi","journal-title":"Iran J Public Health"},{"issue":"3","key":"R20","doi-asserted-by":"publisher","first-page":"265","DOI":"10.4103\/jisppd.jisppd_278_22","article-title":"Comparison of craniofacial morphology characteristics along with dental caries status and salivary properties of operated cleft lip and palate patients with noncleft patients","volume":"40","author":"Talukdar","journal-title":"J Indian Soc Pedod Prev Dent"},{"issue":"6","key":"R21","doi-asserted-by":"publisher","first-page":"e240","DOI":"10.1016\/j.oooo.2015.08.009","article-title":"Mucopolysaccharidosis: radiographic findings in a series of 16 cases","volume":"120","author":"de Santana Sarmento","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"issue":"2","key":"R22","doi-asserted-by":"publisher","first-page":"83","DOI":"10.4103\/jisppd.jisppd_28_24","article-title":"Caries assessment and salivary microbial analysis in patients diagnosed with mucopolysaccharidosis","volume":"42","author":"Anju","journal-title":"J Indian Soc Pedod Prev Dent"},{"issue":"1","key":"R23","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-019-1114-5","article-title":"Assessing a possible vulnerability to dental caries in individuals with rare genetic diseases that affect the skeletal development","volume":"14","author":"Prado","journal-title":"Orphanet J Rare Dis"}],"container-title":["JMIR Pediatrics and Parenting"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pediatrics.jmir.org\/2026\/1\/e87430","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T17:14:45Z","timestamp":1782839685000},"score":1,"resource":{"primary":{"URL":"https:\/\/pediatrics.jmir.org\/2026\/1\/e87430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,4]]},"references-count":23,"URL":"https:\/\/doi.org\/10.2196\/87430","relation":{},"ISSN":["2561-6722"],"issn-type":[{"value":"2561-6722","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,4]]},"article-number":"v9i7e87430"}}