{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:43:25Z","timestamp":1785545005860,"version":"3.56.0"},"reference-count":46,"publisher":"JMIR Publications Inc.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMIR Form Res"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec sec-type=\"background\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Virtual reality (VR) systems are increasingly used in rehabilitation to facilitate motor learning by providing visual feedback. However, few studies have validated the motion tracking accuracy of VR devices compared with gold-standard motion capture systems. In particular, validation evidence for upper-limb reaching with commercially available VR tracking setups remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"objective\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to evaluate the validity of a custom VR-based rehabilitation system (VRactice) by comparing its motion tracking data with that of a Vicon motion capture system during a goal-directed reaching task in healthy adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This laboratory-based validation study was conducted at Tokyo Kasei University, Sayama Campus, Japan (August-December 2023). Participants were recruited via posted announcements on campus (convenience sampling) and received a 1000 JPY gift card (US $7.00; JPY 142.79=US $1 as of August 1, 2023). A total of 16 healthy participants (n=6, 37.5% male and n=10, 62.5% female participants; mean age 25.3, SD 4.56 years; all right-handed) performed reaching tasks in a VR environment while being tracked simultaneously by both the VRactice system and a Vicon system. Trackers and reflective markers were attached to the hand and elbow to capture 3D coordinates. Each participant performed 10 reaching trials at a frequency of 1 Hz. Data were upsampled to 100 Hz, synchronized, and normalized to the initial position. Valid cycles were identified, and distance time series from the initial position were extracted for the 500-millisecond interval preceding the peak displacement. For each participant, all valid cycles were pooled, and the coefficient of determination (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      ) between VRactice and Vicon trajectories was calculated. Of 160 planned trials (16 participants\u00d710 trials), 4 (2.5%) trials were not recorded; the remaining 156 (97.5%) trials were analyzed without imputation. Statistical significance was evaluated at a 2-sided \u03b1 level of .05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Strong agreement between VRactice and Vicon was observed at both the individual and group levels. The\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      ranged from 0.75 to 0.99 across participants, and all comparisons were statistically significant (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;.001). Deviations between the 2 systems remained minimal, confirming that VRactice reliably reproduced the temporal and spatial characteristics of reaching trajectories. At peak displacement, the participant-level mean absolute difference (mean of 10 trials per participant) was 36.5 (SD 29.3) mm (95% CI 20.9\u201052.1), suggesting spatial agreement that may be acceptable for upper-limb reaching measurements in this experimental context.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The findings support the validity of VRactice in capturing reaching movements with high spatial accuracy compared with a motion capture system. By providing reliable motion data, VRactice may serve as a useful platform for delivering real-time visual feedback and supporting motor training applications in rehabilitation settings. This study is innovative in that it provides formative validity evidence for a VR-based system that integrates real-time trajectory monitoring with adaptive visual guidance, supporting subsequent clinical implementation and evaluation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2196\/89302","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T19:50:07Z","timestamp":1776282607000},"page":"e89302-e89302","source":"Crossref","is-referenced-by-count":0,"title":["Feedback-Enhanced Virtual Reality Upper-Limb Training With Body Position Measurement in Healthy Adults: Development and Validation Study"],"prefix":"10.2196","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9149-3039","authenticated-orcid":false,"given":"Naoki","family":"Iso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8841-9399","authenticated-orcid":false,"given":"Makoto","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3360-5068","authenticated-orcid":false,"given":"Takuhiro","family":"Okabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7026-5395","authenticated-orcid":false,"given":"Kazuo","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1558-2520","authenticated-orcid":false,"given":"Kilchoon","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3594-349X","authenticated-orcid":false,"given":"Takuya","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7008-0755","authenticated-orcid":false,"given":"Takako","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3164-0834","authenticated-orcid":false,"given":"Nanaka","family":"Arihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4703-6201","authenticated-orcid":false,"given":"Junichi","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1010","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"issue":"1","key":"R1","doi-asserted-by":"publisher","first-page":"S225","DOI":"10.1044\/1092-4388(2008\/018)","article-title":"Principles of experience-dependent neural plasticity: implications for rehabilitation after brain damage","volume":"51","author":"Kleim","journal-title":"J Speech Lang Hear Res"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1221656","article-title":"A scoping review of scientific concepts concerning motor recovery after stroke as employed in clinical trials","volume":"14","author":"Favetta","journal-title":"Front Neurol"},{"issue":"1-3","key":"R3","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1080\/10833196.2024.2362045","article-title":"The effectiveness of the motor relearning program on upper limb function post-stroke: a systematized review","volume":"29","author":"O\u2019Rourke","journal-title":"Phys Ther Rev"},{"key":"R4","doi-asserted-by":"crossref","unstructured":"Kitago T Krakauer JW . Motor learning principles for neurorehabilitation. In: Aminoff MJ Boller F Swaab DF , editors. Handbook of Clinical Neurology. 2013:93-103. URL: https:\/\/www.sciencedirect.com\/science\/chapter\/handbook\/abs\/pii\/B9780444529015000083?via%3Dihub [Accessed 09-06-2026]","DOI":"10.1016\/B978-0-444-52901-5.00008-3"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-5465-6_3","article-title":"Neurocognitive mechanisms of error-based motor learning","volume":"782","author":"Seidler","journal-title":"Adv Exp Med Biol"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-060909-153135","article-title":"Error correction, sensory prediction, and adaptation in motor control","volume":"33","author":"Shadmehr","journal-title":"Annu Rev Neurosci"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6925","article-title":"Prospective errors determine motor learning","volume":"6","author":"Takiyama","journal-title":"Nat Commun"},{"issue":"4","key":"R8","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004149.pub3","article-title":"Constraint-induced movement therapy in children with unilateral cerebral palsy","volume":"4","author":"Hoare","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"R9","doi-asserted-by":"publisher","first-page":"57","DOI":"10.3233\/RNN-140418","article-title":"Do all subacute stroke patients benefit from robot-assisted therapy? A retrospective study","volume":"33","author":"Duret","journal-title":"Restor Neurol Neurosci"},{"issue":"4","key":"R10","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1016\/j.conb.2011.06.012","article-title":"Human sensorimotor learning: adaptation, skill, and beyond","volume":"21","author":"Krakauer","journal-title":"Curr Opin Neurobiol"},{"issue":"11","key":"R11","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010820.pub2","article-title":"Interventions for improving upper limb function after stroke","volume":"2014","author":"Pollock","journal-title":"Cochrane Database Syst Rev"},{"issue":"21","key":"R12","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph192114125","article-title":"The effect of task-oriented activities training on upper-limb function, daily activities, and quality of life in chronic stroke patients: a randomized controlled trial","volume":"19","author":"Alsubiheen","journal-title":"Int J Environ Res Public Health"},{"issue":"3","key":"R13","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1097\/MRR.0000000000000169","article-title":"Constraint-induced movement therapy as a rehabilitation intervention for upper extremity in stroke patients: systematic review and meta-analysis","volume":"39","author":"Etoom","journal-title":"Int J Rehabil Res"},{"issue":"2","key":"R14","doi-asserted-by":"publisher","first-page":"203","DOI":"10.3109\/02699052.2013.860472","article-title":"Repetitive facilitative exercise under continuous electrical stimulation for severe arm impairment after sub-acute stroke: a randomized controlled pilot study","volume":"28","author":"Shimodozono","journal-title":"Brain Inj"},{"issue":"11","key":"R15","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.3109\/00207454.2015.1094473","article-title":"Effects of repetitive facilitative exercise with neuromuscular electrical stimulation, vibratory stimulation and repetitive transcranial magnetic stimulation of the hemiplegic hand in chronic stroke patients","volume":"126","author":"Etoh","journal-title":"Int J Neurosci"},{"issue":"11","key":"R16","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1016\/j.medengphy.2016.09.001","article-title":"Hybrid robotic systems for upper limb rehabilitation after stroke: a review","volume":"38","author":"Resqu\u00edn","journal-title":"Med Eng Phys"},{"issue":"1","key":"R17","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3758\/s13423-012-0333-8","article-title":"Augmented visual, auditory, haptic, and multimodal feedback in motor learning: a review","volume":"20","author":"Sigrist","journal-title":"Psychon Bull Rev"},{"issue":"5","key":"R18","doi-asserted-by":"publisher","first-page":"7405205060p1","DOI":"10.5014\/ajot.2020.041442","article-title":"Applications of head-mounted displays for virtual reality in adult physical rehabilitation: a scoping review","volume":"74","author":"Saldana","journal-title":"Am J Occup Ther"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1186\/1743-0003-8-33","article-title":"The development of an adaptive upper-limb stroke rehabilitation robotic system","volume":"8","author":"Kan","journal-title":"J Neuroeng Rehabil"},{"issue":"1","key":"R20","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1111\/nyas.14554","article-title":"A novel fully immersive virtual reality environment for upper extremity rehabilitation in patients with stroke","volume":"1493","author":"Mekbib","journal-title":"Ann N Y Acad Sci"},{"issue":"1","key":"R21","doi-asserted-by":"publisher","DOI":"10.1186\/s12911-024-02534-y","article-title":"The efficacy of virtual reality for upper limb rehabilitation in stroke patients: a systematic review and meta-analysis","volume":"24","author":"Soleimani","journal-title":"BMC Med Inform Decis Mak"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1186\/1743-0003-4-20","article-title":"Virtual reality environments for post-stroke arm rehabilitation","volume":"4","author":"Subramanian","journal-title":"J Neuroeng Rehabil"},{"issue":"9","key":"R23","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1093\/ptj\/82.9.898","volume":"82","author":"Merians","journal-title":"Phys Ther"},{"issue":"4","key":"R24","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1177\/1073858414541484","article-title":"Motor planning","volume":"21","author":"Wong","journal-title":"Neuroscientist"},{"issue":"3","key":"R25","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1037\/0033-2909.95.3.355","article-title":"Knowledge of results and motor learning: a review and critical reappraisal","volume":"95","author":"Salmoni","journal-title":"Psychol Bull"},{"issue":"4","key":"R26","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1080\/02701367.1994.10607635","article-title":"Effects of physical guidance and knowledge of results on motor learning: support for the guidance hypothesis","volume":"65","author":"Winstein","journal-title":"Res Q Exerc Sport"},{"issue":"17","key":"R27","doi-asserted-by":"publisher","DOI":"10.3390\/s23177371","article-title":"Measurement accuracy of the HTC VIVE Tracker 3.0 compared to Vicon system for generating valid positional feedback in virtual reality","volume":"23","author":"Merker","journal-title":"Sensors (Basel)"},{"issue":"11","key":"R28","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008349.pub4","article-title":"Virtual reality for stroke rehabilitation","volume":"11","author":"Laver","journal-title":"Cochrane Database Syst Rev"},{"issue":"6","key":"R29","doi-asserted-by":"publisher","DOI":"10.2196\/24111","article-title":"Effectiveness of using virtual reality-supported exercise therapy for upper extremity motor rehabilitation in patients with stroke: systematic review and meta-analysis of randomized controlled trials","volume":"24","author":"Chen","journal-title":"J Med Internet Res"},{"issue":"4","key":"R30","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1080\/02699052.2020.1725126","article-title":"Virtual reality therapy for upper limb rehabilitation in patients with stroke: a meta-analysis of randomized clinical trials","volume":"34","author":"Mekbib","journal-title":"Brain Inj"},{"issue":"1","key":"R31","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13010146","article-title":"Effects of immersive virtual reality on upper-extremity stroke rehabilitation: a systematic review with meta-analysis","volume":"13","author":"Kiper","journal-title":"J Clin Med"},{"issue":"8","key":"R32","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1016\/j.apmr.2012.03.005","article-title":"Optimizing terminology for stroke motor rehabilitation: recommendations from the American Congress of Rehabilitation Medicine Stroke Movement Interventions Subcommittee","volume":"93","author":"Page","journal-title":"Arch Phys Med Rehabil"},{"issue":"1","key":"R33","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/0028-3932(71)90067-4","article-title":"The assessment and analysis of handedness: the Edinburgh inventory","volume":"9","author":"Oldfield","journal-title":"Neuropsychologia"},{"issue":"12","key":"R34","doi-asserted-by":"publisher","DOI":"10.2196\/12339","article-title":"Evaluating the effectiveness and safety of the electroencephalogram-based brain-machine interface rehabilitation system for patients with severe hemiparetic stroke: protocol for a randomized controlled trial (BEST-BRAIN trial)","volume":"7","author":"Mizuno","journal-title":"JMIR Res Protoc"},{"issue":"5","key":"R35","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1002\/acn3.544","article-title":"Brain-computer interfaces for post-stroke motor rehabilitation: a meta-analysis","volume":"5","author":"Cervera","journal-title":"Ann Clin Transl Neurol"},{"issue":"1","key":"R36","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1177\/15500594211009065","article-title":"Efficacy of brain-computer interface and the impact of its design characteristics on poststroke upper-limb rehabilitation: a systematic review and meta-analysis of randomized controlled trials","volume":"53","author":"Mansour","journal-title":"Clin EEG Neurosci"},{"issue":"1","key":"R37","doi-asserted-by":"publisher","DOI":"10.1186\/s12984-025-01588-x","article-title":"Effects of brain-computer interface based training on post-stroke upper-limb rehabilitation: a meta-analysis","volume":"22","author":"Li","journal-title":"J Neuroeng Rehabil"},{"issue":"10","key":"R38","doi-asserted-by":"publisher","DOI":"10.2196\/31051","article-title":"Effects of virtual reality training on upper limb function and balance in stroke patients: systematic review and meta-meta-analysis","volume":"23","author":"Wu","journal-title":"J Med Internet Res"},{"issue":"7","key":"R39","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare10071175","article-title":"Virtual feedback for arm motor function rehabilitation after stroke: a randomized controlled trial","volume":"10","author":"Salvalaggio","journal-title":"Healthcare (Basel)"},{"issue":"5","key":"R40","doi-asserted-by":"publisher","first-page":"287","DOI":"10.3233\/RNN-2011-0599","article-title":"Virtual reality based rehabilitation speeds up functional recovery of the upper extremities after stroke: a randomized controlled pilot study in the acute phase of stroke using the rehabilitation gaming system","volume":"29","author":"da Silva Cameir\u00e3o","journal-title":"Restor Neurol Neurosci"},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1016\/j.chb.2017.01.013","article-title":"A meta-analysis and systematic literature review of virtual reality rehabilitation programs","volume":"70","author":"Howard","journal-title":"Comput Hum Behav"},{"issue":"3","key":"R42","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1089\/g4h.2017.0114","article-title":"Comparison of Oculus Rift and HTC Vive: feasibility for virtual reality-based exploration, navigation, exergaming, and rehabilitation","volume":"7","author":"Borrego","journal-title":"Games Health J"},{"key":"R43","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2019.02.015","article-title":"Feasibility of using a fully immersive virtual reality system for kinematic data collection","volume":"87","author":"Spitzley","journal-title":"J Biomech"},{"issue":"3","key":"R44","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.gaitpost.2012.03.033","article-title":"Validity of the Microsoft Kinect for assessment of postural control","volume":"36","author":"Clark","journal-title":"Gait Posture"},{"issue":"8","key":"R45","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/nrn2672","article-title":"Inside the brain of an elite athlete: the neural processes that support high achievement in sports","volume":"10","author":"Yarrow","journal-title":"Nat Rev Neurosci"},{"issue":"8","key":"R46","doi-asserted-by":"publisher","first-page":"5466","DOI":"10.1109\/TVCG.2023.3295425","article-title":"Visual illusion created by a striped pattern through augmented reality for the prevention of tumbling on stairs","volume":"30","author":"Miura","journal-title":"IEEE Trans Vis Comput Graph"}],"container-title":["JMIR Formative Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/formative.jmir.org\/2026\/1\/e89302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T22:24:40Z","timestamp":1785536680000},"score":1,"resource":{"primary":{"URL":"https:\/\/formative.jmir.org\/2026\/1\/e89302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,16]]},"references-count":46,"URL":"https:\/\/doi.org\/10.2196\/89302","relation":{},"ISSN":["2561-326X"],"issn-type":[{"value":"2561-326X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,16]]},"article-number":"v10i1e89302"}}