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Understanding the role of dispositional and developmental differences in individuals\u2019 responses to online versus offline social interactions may help elucidate whether and how online social interaction is related to anxiety and depression.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n This study aimed to investigate the relationship between older adolescents\u2019 and emerging adults\u2019 (18\u201024-year-olds) mental health and (1) objectively measured time spent on smartphones and online social interaction apps, (2) momentary affective and affiliative responses to online and offline social interactions, and (3) the moderating role of developmentally and dispositionally elevated social sensitivity.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Smartphone, social media (eg, Instagram), SMS, and internet (eg, WhatsApp) text messaging app time from participants\u2019 screen use settings, as well as symptoms of anxiety and depression, and social sensitivity, were measured in 190 older adolescents and emerging adults (mean age 20.4, SD 2.2 years). Participants then completed a novel ecological momentary assessment (EMA) capturing affective and affiliative responses to recent online or offline social interactions 3\u00d7 daily for 1 week. Symptoms of mental health were assessed again after 1 month.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Total online social interaction (combined social media and text messaging) app time, but not total smartphone time, was associated with greater anxiety, at both baseline and one month later. Affective and affiliative responses were less positive for online social interactions compared to in-person interactions. Anxiety, but not depression, was associated with feeling less happy, but not less included, after social interactions. Affective and affiliative responses to in-person, but not online, social interactions were negatively associated with depression across the 1-month study period. Finally, social sensitivity moderated the relationship between affective and affiliative responses to social media interactions and depression at baseline. Overall effect sizes were small.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n These findings emphasize the need to investigate individual factors influencing for whom online social interaction is harmful or beneficial. To do so, this study provides a novel, ecologically valid tool for understanding young people\u2019s momentary responses to online and offline social interactions, as well as initial evidence for stronger associations between in-person than online social interaction responses and mental health for older adolescents and emerging adults. It also introduces evidence of social sensitivity as a potential, developmentally relevant vulnerability to the effects of online social interaction. Further research is needed in younger adolescent populations over longer timeframes.<\/jats:p>\n <\/jats:sec>","DOI":"10.2196\/94753","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T12:45:06Z","timestamp":1782132306000},"page":"e94753-e94753","source":"Crossref","is-referenced-by-count":0,"title":["Momentary Mood and Affiliation Following Social Interactions in the Digital Age: Longitudinal Study Investigating Associations With Anxiety and Depression"],"prefix":"10.2196","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7865-287X","authenticated-orcid":false,"given":"Anna","family":"Bilston","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8384-1867","authenticated-orcid":false,"given":"Sarah","family":"Daniels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6607-5078","authenticated-orcid":false,"given":"Yasmin","family":"Hasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6153-8291","authenticated-orcid":false,"given":"Susanne","family":"Schweizer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1010","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"R1","unstructured":"Kemp S . 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