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The aim of this viewpoint is to present a conceptual framework that reframes endoscopic visualization as a spatiotemporal information integration problem rather than solely a display problem. We discuss how future visualization systems may integrate spatial and temporal information to support externalized representations of anatomy, endoscope configuration, and procedural dynamics in a shared clinical environment. Potential applications include endoscopic navigation, training, and collaborative procedures. We further discuss key technical and clinical considerations, including information integration, registration stability, real-time responsiveness, workflow compatibility, and uncertainty associated with reconstructed information. This viewpoint highlights spatiotemporal information integration as a central challenge in the development of next-generation visualization systems for gastrointestinal endoscopy.<\/jats:p>","DOI":"10.2196\/99446","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T20:42:11Z","timestamp":1787863331000},"page":"e99446-e99446","source":"Crossref","is-referenced-by-count":0,"title":["A Conceptual Framework for 4D Holographic Visualization in Gastrointestinal Endoscopy: Toward Externalized Spatiotemporal 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