{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T10:41:22Z","timestamp":1751020882735,"version":"3.40.5"},"reference-count":68,"publisher":"JMIR Publications Inc.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JMIR Res Protoc"],"abstract":"<jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Effective medication management is one of the essential preconditions for enabling polymedicated home-dwelling older adults with multiple chronic conditions to remain at home and preserve their quality of life and autonomy. Lack of effective medication management predisposes older adults to medication-related problems (MRPs) and adverse health outcomes, which can lead to the degradation of a patient\u2019s acute clinical condition, physical and cognitive decline, exacerbation of chronic medical conditions, and avoidable health care costs. Nonetheless, it has been shown that MRPs can be prevented or reduced by using well-coordinated, patient-centered, interprofessional primary care interventions.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Objective<\/jats:title>\n            <jats:p>This study aimed to explore the feasibility and acceptability of an evidence-based, multicomponent, interprofessional intervention program supported by informal caregivers to decrease MRPs among polymedicated home-dwelling older adults with multiple chronic conditions.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>This quasi-experimental, pre-post, multisite pilot, and feasibility study will use an open-label design, with participants knowing the study\u2019s objectives and relevant information, and it will take place in primary health care settings in Portugal and Switzerland. The research population will comprise 30 polymedicated, home-dwelling adults, aged \u226565 years at risk of MRPs and receiving community-based health care, along with their informal caregivers and health care professionals.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Before a projected full-scale study, this pilot and feasibility study will focus on recruiting and ensuring the active collaboration of its participants and on the feasibility of expanding this evidence-based, multicomponent, interprofessional intervention program throughout both study regions. This study will also be essential to projected follow-up research programs on informal caregivers\u2019 multiple roles, enhancing their coordination tasks and their own needs. Results are expected at the end of 2024.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Designing, establishing, and exploring the feasibility and acceptability of an intervention program to reduce the risks of MRPs among home-dwelling older adults is an underinvestigated issue. Doing so in collaboration with all the different actors involved in that population\u2019s medication management and recording the first effects of the intervention will make this pilot and feasibility study\u2019s findings very valuable as home care becomes an ever more common solution.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Trial Registration<\/jats:title>\n            <jats:p>Swiss National Clinical Trials Portal 000004654; https:\/\/tinyurl.com\/mr3yz8t4<\/jats:p>\n          <\/jats:sec>","DOI":"10.2196\/39130","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T14:45:44Z","timestamp":1670597144000},"page":"e39130","source":"Crossref","is-referenced-by-count":3,"title":["An Intervention Program to Reduce Medication-Related Problems Among Polymedicated Home-Dwelling Older Adults (OptiMed): Protocol for a Pre-Post, Multisite, Pilot, and Feasibility Study"],"prefix":"10.2196","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9207-4856","authenticated-orcid":false,"given":"Filipa","family":"Pereira","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9035-8548","authenticated-orcid":false,"given":"Maria dos Anjos","family":"Dixe","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8197-1850","authenticated-orcid":false,"given":"S\u00f3nia","family":"Gon\u00e7alves Pereira","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3523-5729","authenticated-orcid":false,"given":"Carla","family":"Meyer-Massetti","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5375-3255","authenticated-orcid":false,"given":"Henk","family":"Verloo","sequence":"additional","affiliation":[]}],"member":"1010","published-online":{"date-parts":[[2023,1,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1590\/1980-57642020dn14-010005"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-017-0621-2"},{"key":"ref3","unstructured":"Mon\u00e9gatMSermetCPerronninMRococoELa sant\u00e9 des ch\u00f4meurs en France : revue de la litt\u00e9rature - Revue d'\u00c9pid\u00e9miologie et de Sant\u00e9 PubliqueInstitut de recherche et documentation en \u00e9conomie de la sant\u00e92014122022-12-18https:\/\/www.irdes.fr\/recherche\/questions-d-economie-de-la-sante\/204-la-polymedication-definitions-mesures-et-enjeux.pdf"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12293"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/1757-7241-21-15"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061735"},{"key":"ref7","unstructured":"RenardDFustinoniSSeematter-BagnoudLSantos-EggimannBM\u00e9dicaments chez les seniors vaudois \u00e0 domicile : nombre et compositionCentre d\u2019Observation et d\u2019Analyse du Vieillissement20152022-12-18Lausanne, SwitzerlandCentre d\u2019Observation et d\u2019Analyse du Vieillissementhttps:\/\/serval.unil.ch\/resource\/serval:BIB_A61083A8B4D6.P001\/REF"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2018.06.018"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.japh.2017.06.019"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/s12875-017-0642-0"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.18773\/austprescr.2018.012"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13017"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-010003"},{"key":"ref14","unstructured":"How-to Guide: Prevent Adverse Drug Events (Medication Reconciliation)Institute for Healthcare Improvement2011122022-12-18Cambridge, MA, USAInstitute for Healthcare Improvementhttps:\/\/www.ihi.org\/Topics\/ADEsMedicationReconciliation\/Pages\/default.aspx#:~:text=Medication%20reconciliation%20is%20the%20process,goal%20of%20providing%20correct%20medications"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s41999-021-00449-9"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afu145"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15767"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31188-1"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S232575"},{"key":"ref20","unstructured":"GilbertARougheadLMcDermottRRyanPEstermanAShakibSLuszczMVitryACaugheyGPreissKRamsayEClarkAZhangYMultiple Chronic Health Conditions in Older People: Implications for Health Policy Planning, Practitioners and PatientsUniversity of South Australia20132022-12-18Adelaide, AustraliaUniversity of South Australiahttps:\/\/www.unisa.edu.au\/siteassets\/episerver-6-files\/global\/health\/sansom\/documents\/qumprc\/multiple-chronic-health-conditions.pdf"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.2217\/ahe.11.64"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-012-0028-x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s10900-011-9405-3"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afx076"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-017-0513-8"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1007\/BF03391611"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp11X548929"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-7625.2011.00714.x"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1111\/hex.12967"},{"journal-title":"WHO Guidelines on Hand Hygiene in Health Care: First Global Patient Safety Challenge Clean Care Is Safer Care","year":"2009","key":"ref30"},{"key":"ref31","first-page":"139","author":"Angelmar, R","year":"2007","journal-title":"Financing Sustainable Healthcare in Europe: New Approaches for New Outcomes"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-018-0849-5"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.sapharm.2017.05.005"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1111\/jocn.12519"},{"key":"ref35","unstructured":"Commission consultative du soutien aux proches aidants\u00c9tat de Vaud20182022-12-18https:\/\/www.vd.ch\/themes\/aides-financieres-et-soutien-social\/proches-aidants\/commission-consultative-du-soutien-aux-proches-aidants"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-10-1"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-022233"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a1655"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n2061"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1623"},{"issue":"2","key":"ref41","first-page":"53","volume":"2018","author":"Meyer-Massetti, C","year":"2018","journal-title":"Pharma J"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0150205"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijosm.2017.02.001"},{"key":"ref44","unstructured":"Pilot Studies: Common Uses and MisusesNational Center for Complementary and Integrative Health202011182022-12-18Bethesda, MD, USAU.S. National Institutes of Healthhttps:\/\/www.nccih.nih.gov\/grants\/pilot-studies-common-uses-and-misuses"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1186\/s40814-021-00931-y"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-618X.2007.00067.x"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.4137\/HSI.S11093"},{"key":"ref48","unstructured":"COnsensus-based Standards for the selection of health Measurement INstrumentsCOSMIN20202022-12-18https:\/\/www.cosmin.nl\/"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-018-1007-9"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e7586"},{"journal-title":"Probability and Statistical Inference. 8th edition","year":"2010","author":"Hogg, RV","key":"ref51"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1159\/000448241"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S243233"},{"journal-title":"International Classification of Diseases. 11th Revision (ICD-11)","year":"2022","key":"ref54"},{"journal-title":"Health Intervention Research: Understanding Research Design and Methods","year":"2014","author":"Sidani, S","key":"ref55"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.140.6.734"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.114.512.797"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1080\/13607863.2013.856864"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1080\/13607863.2017.1348473"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2017.02.009"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2017.07.008"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2009.11.003"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.12373"},{"key":"ref64","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511996214","author":"de Vet, HC","year":"2011","journal-title":"Measurement in Medicine: A Practical Guide"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2017.05.010"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-030030"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2011.03763.x"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1370\/afm.1713"}],"container-title":["JMIR Research Protocols"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T13:30:58Z","timestamp":1674653458000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.researchprotocols.org\/2023\/1\/e39130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,25]]},"references-count":68,"URL":"https:\/\/doi.org\/10.2196\/39130","relation":{},"ISSN":["1929-0748"],"issn-type":[{"type":"electronic","value":"1929-0748"}],"subject":[],"published":{"date-parts":[[2023,1,25]]}}}