{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:46:14Z","timestamp":1777553174723,"version":"3.51.4"},"reference-count":140,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2012,7,24]],"date-time":"2012-07-24T00:00:00Z","timestamp":1343088000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dose-Response"],"published-print":{"date-parts":[[2013,4,1]]},"abstract":"<jats:p>Although the adult human brain has a small number of neural stem cells, they are insufficient to repair the damaged brain to achieve significant functional recovery for neurodegenerative diseases and stroke. Stem cell therapy, by either enhancing endogenous neurogenesis, or transplanting stem cells, has been regarded as a promising solution. However, the harsh environment of the diseased brain posts a severe threat to the survival and correct differentiation of those new stem cells. Hormesis (or preconditioning, stress adaptation) is an adaptation mechanism by which cells or organisms are potentiated to survive an otherwise lethal condition, such as the harsh oxidative stress in the stroke brain. Stem cells treated by low levels of chemical, physical, or pharmacological stimuli have been shown to survive better in the neurodegenerative brain. Thus combining hormesis and stem cell therapy might improve the outcome for treatment of these diseases. In addition, since the cell death patterns and their underlying molecular mechanism may vary in different neurodegenerative diseases, even in different progression stages of the same disease, it is essential to design a suitable and optimum hormetic strategy that is tailored to the individual patient.<\/jats:p>","DOI":"10.2203\/dose-response.12-019.wang","type":"journal-article","created":{"date-parts":[[2012,7,26]],"date-time":"2012-07-26T12:03:11Z","timestamp":1343304191000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Hormesis, Cell Death, and Regenerative Medicine for Neurodegenerative Diseases"],"prefix":"10.1177","volume":"11","author":[{"given":"Guanghu","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,7,24]]},"reference":[{"key":"bibr1-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.09.081"},{"key":"bibr2-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/nn1707"},{"key":"bibr3-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2009.20"},{"key":"bibr4-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1101\/gad.869001"},{"key":"bibr5-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb04051.x"},{"key":"bibr6-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.05.031"},{"key":"bibr7-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2006.03.003"},{"key":"bibr8-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401166"},{"key":"bibr9-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2010.50"},{"key":"bibr10-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2009.17"},{"key":"bibr11-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20800"},{"key":"bibr12-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(03)00051-0"},{"key":"bibr13-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-2223"},{"key":"bibr14-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2011.197"},{"key":"bibr15-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2011.91"},{"key":"bibr16-dose-response.12-019.Wang","doi-asserted-by":"crossref","unstructured":"Calabrese EJ, Bachmann KA, Bailer AJ, Bolger PM, Borak J, Cai L, Cedergreen N, Cherian MG, Chiueh CC, Clarkson TW, Cook RR, Diamond DM, Doolittle DJ, Dorato MA, Duke SO, Feinendegen L, Gardner DE, Hart RW, Hastings KL, Hayes AW, Hoffmann GR, Ives JA, Jaworowski Z, Johnson TE, Jonas WB, Kaminski NE, Keller JG, Klaunig JE, Knudsen TB, Kozumbo WJ, Lettieri T, Liu SZ, Maisseu A, Maynard KI, Masoro EJ, McClellan RO, Mehendale HM, Mothersill C, Newlin DB, Nigg HN, Oehme FW, Phalen RF, Philbert MA, Rattan SI, Riviere JE, Rodricks J, Sapolsky RM, Scott BR, Seymour C, Sinclair DA, Smith-Sonneborn J, Snow ET, Spear L, Stevenson DE, Thomas Y, Tubiana M, Williams GM and Mattson MP. 2007. Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework. Toxicol Appl Pharmacol.","DOI":"10.1016\/j.taap.2007.02.015"},{"key":"bibr17-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.publhealth.22.1.15"},{"key":"bibr18-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200700316"},{"key":"bibr19-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.3074"},{"key":"bibr20-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-008-9775-9"},{"key":"bibr21-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.3727\/000000007783464669"},{"key":"bibr22-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2010.59"},{"key":"bibr23-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2011.130"},{"key":"bibr24-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000250235.80253.e9"},{"key":"bibr25-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2010.123"},{"key":"bibr26-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.8606"},{"key":"bibr27-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2009.3"},{"key":"bibr28-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2009.364"},{"key":"bibr29-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07335-X"},{"key":"bibr30-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2010.89"},{"key":"bibr31-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207107"},{"key":"bibr32-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.83"},{"key":"bibr33-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio711"},{"key":"bibr34-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2010.9"},{"key":"bibr35-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.5604\/17322693.946637"},{"key":"bibr36-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2009.33"},{"key":"bibr37-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/3305"},{"key":"bibr38-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2010.15"},{"key":"bibr39-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2006.06.014"},{"key":"bibr40-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.4.1907-1916.2005"},{"key":"bibr41-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2009.22"},{"key":"bibr42-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.4161\/cc.7.13.6222"},{"key":"bibr43-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3504"},{"key":"bibr44-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1042\/BST0360786"},{"key":"bibr45-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2011.96"},{"key":"bibr46-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1299.126"},{"key":"bibr47-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401794"},{"key":"bibr48-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2010.130"},{"key":"bibr49-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2006.11.001"},{"key":"bibr50-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.2174\/187152707783220901"},{"key":"bibr51-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00564.x"},{"key":"bibr52-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-200502000-00012"},{"key":"bibr53-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-009-9161-2"},{"key":"bibr54-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.05.021"},{"key":"bibr55-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e3181b7d137"},{"key":"bibr56-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.8.8.1193"},{"key":"bibr57-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2008.06599.x"},{"key":"bibr58-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1002\/stem.789"},{"key":"bibr59-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0006-07.2007"},{"key":"bibr60-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1002\/stem.584"},{"key":"bibr61-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2006.07.006"},{"key":"bibr62-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.4.2.1508"},{"key":"bibr63-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200102120-00031"},{"key":"bibr64-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2011.07.027"},{"key":"bibr65-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1172\/JCI19906"},{"key":"bibr66-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.02.015"},{"key":"bibr67-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0404474101"},{"key":"bibr68-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1177\/1091581810363012"},{"key":"bibr69-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1354.028"},{"key":"bibr70-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-2455"},{"key":"bibr71-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00013.2006"},{"key":"bibr72-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2008.150"},{"key":"bibr73-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2007.12.001"},{"key":"bibr74-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(08)01416-X"},{"key":"bibr75-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2009.10.026"},{"key":"bibr76-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1179\/174313208X289615"},{"key":"bibr77-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2010.76"},{"key":"bibr78-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-010-0809-1"},{"key":"bibr79-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2010.83"},{"key":"bibr80-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2010.21"},{"key":"bibr81-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2007.12.001"},{"key":"bibr82-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.20674"},{"key":"bibr83-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1160\/TH09-12-0839"},{"key":"bibr84-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200204000-00007"},{"key":"bibr85-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600371"},{"key":"bibr86-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2004.04.011"},{"key":"bibr87-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/ncb0910-842"},{"key":"bibr88-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2006-0018"},{"key":"bibr89-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2006.12.003"},{"key":"bibr90-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(91)90136-E"},{"key":"bibr91-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2007.07.003"},{"key":"bibr92-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100380"},{"key":"bibr93-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2007.08.007"},{"key":"bibr94-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2008.06420.x"},{"key":"bibr95-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2010.28"},{"key":"bibr96-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207559"},{"key":"bibr97-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1354.063"},{"key":"bibr98-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1089\/152308604322899521"},{"key":"bibr99-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2010.24"},{"key":"bibr100-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4400640"},{"key":"bibr101-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200105080-00016"},{"key":"bibr102-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1297.103"},{"key":"bibr103-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2006.105.1.96"},{"key":"bibr104-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.09.110"},{"key":"bibr105-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5686-11.2012"},{"key":"bibr106-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00544.2011"},{"key":"bibr107-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2010.4"},{"key":"bibr108-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.601914"},{"key":"bibr109-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/nature00858"},{"key":"bibr110-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2010.74"},{"key":"bibr111-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.2174\/1567205054367919"},{"key":"bibr112-dose-response.12-019.Wang","first-page":"87","volume":"48","author":"Sugaya K","year":"2006","journal-title":"Panminerva Med"},{"key":"bibr113-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1093\/embo-reports\/kvf138"},{"key":"bibr114-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2010.65"},{"key":"bibr115-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2010.5"},{"key":"bibr116-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvi056"},{"key":"bibr117-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.12.020"},{"key":"bibr118-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1161\/hc0102.101442"},{"key":"bibr119-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2887"},{"key":"bibr120-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2970"},{"key":"bibr121-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2011.164"},{"key":"bibr122-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2010.36"},{"key":"bibr123-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1002\/gene.1064"},{"key":"bibr124-dose-response.12-019.Wang","first-page":"703","volume":"117","author":"Wang G","year":"2011","journal-title":"J Neurochem"},{"key":"bibr125-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1002\/gene.20005"},{"key":"bibr126-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1002\/gene.10200"},{"key":"bibr127-dose-response.12-019.Wang","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1002\/stem.230","volume":"27","author":"Wang X","year":"2009","journal-title":"Stem Cells"},{"key":"bibr128-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2011.12.015"},{"key":"bibr129-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/nm1298"},{"key":"bibr130-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-006-0066-0"},{"key":"bibr131-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2012.03.002"},{"key":"bibr132-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1716"},{"key":"bibr133-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2007.04.011"},{"key":"bibr134-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200105080-00002"},{"key":"bibr135-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.109.150839"},{"key":"bibr136-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2010.56"},{"key":"bibr137-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2006.06.008"},{"key":"bibr138-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2011.12.004"},{"key":"bibr139-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2010.02.005"},{"key":"bibr140-dose-response.12-019.Wang","doi-asserted-by":"publisher","DOI":"10.1126\/science.1172308"}],"container-title":["Dose-Response"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2203\/dose-response.12-019.Wang","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.2203\/dose-response.12-019.Wang","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2203\/dose-response.12-019.Wang","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:00:51Z","timestamp":1777399251000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.2203\/dose-response.12-019.Wang"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,24]]},"references-count":140,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,4,1]]}},"alternative-id":["10.2203\/dose-response.12-019.Wang"],"URL":"https:\/\/doi.org\/10.2203\/dose-response.12-019.wang","relation":{},"ISSN":["1559-3258","1559-3258"],"issn-type":[{"value":"1559-3258","type":"print"},{"value":"1559-3258","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,24]]},"article-number":"dose-response.12-019.Wang"}}