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J Clin Periodontol 48: 91\u201399.","DOI":"10.1111\/jcpe.13385"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Armitage GC (1999) Development of a classification system for periodontal diseases and conditions. Ann Periodontol 4: 1\u20136.","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Burkhardt R, Ruiz Magaz V, H\u00e4mmerle CHF, Lang NP, Research Group on Oral Soft Tissue Biology & Wound Healing(2016) Interposition of a connective tissue graft or a collagen matrix to enhance wound stability-an experimental study in dogs. J Clin Periodontol 43: 366\u2013373.","DOI":"10.1111\/jcpe.12526"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Camargo PM, Lekovic V, Weinlaender M, Nedic M, Vasilic N, Wolinsky LE, Kenney EB (2000) A controlled re-entry study on the effectiveness of bovine porous bone mineral used in combination with a collagen membrane of porcine origin in the treatment of intrabony defects in humans. J Clin Periodontol 27: 889\u2013896.","DOI":"10.1034\/j.1600-051x.2000.027012889.x"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Cortellini P, Tonetti MS (2001) Microsurgical approach to periodontal regeneration. Initial evaluation in a case cohort. J Periodontol 72: 559\u2013569.","DOI":"10.1902\/jop.2001.72.4.559"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Cortellini P, Tonetti MS (2007) A minimally invasive surgical technique with an enamel matrix derivative in the regenerative treatment of intra-bony defects: a novel approach to limit morbidity. J Clin Periodontol 34: 87\u201393.","DOI":"10.1111\/j.1600-051X.2006.01020.x"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Cortellini P, Tonetti MS (2009) Improved wound stability with a modified minimally invasive surgical technique in the regenerative treatment of isolated interdental intrabony defects. J Clin Periodontol 36: 157\u2013163.","DOI":"10.1111\/j.1600-051X.2008.01352.x"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Cortellini P, Tonetti MS (2011) Clinical and radiographic outcomes of the modified minimally invasive surgical technique with and without regenerative materials: a randomized-controlled trial in intra-bony defects. J Clin Periodontol 38: 365\u2013373.","DOI":"10.1111\/j.1600-051X.2011.01705.x"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Costa FO, Lages EJP, Cota LOM, Lorentz TCM, Soares RV, Cortelli JR (2014) Tooth loss in individuals under periodontal maintenance therapy: 5-year prospective study. J Periodontal Res 49: 121\u2013128.","DOI":"10.1111\/jre.12087"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Ewers R, Goriwoda W, Schopper C, Moser D, Spassova E (2004) Histologic findings at augmented bone areas supplied with two different bone substitute materials combined with sinus floor lifting. Clin Oral Implants Res 15: 96\u2013100.","DOI":"10.1111\/j.1600-0501.2004.00987.x"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) J\u00f6nsson B, \u00d6hrn K, Lindberg P, Oscarson N (2010) Evaluation of an individually tailored oral health educational programme on periodontal health. J Clin Periodontol 37: 912\u2013919.","DOI":"10.1111\/j.1600-051X.2010.01590.x"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Keestra JAJ, Grosjean I, Coucke W, Quirynen M, Teughels W (2015) Non-surgical periodontal therapy with systemic antibiotics in patients with untreated aggressive periodontitis: a systematic review and meta-analysis. J Periodontal Res 50: 689\u2013706.","DOI":"10.1111\/jre.12252"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Kitamura M, Nakashima K, Kowashi Y, Fujii T, Shimauchi H, Sasano T, Furuuchi T, Fukuda M, Noguchi T, Shibutani T, Iwayama Y, Takashiba S, Kurihara H, Ninomiya M, Kido J, Nagata T, Hamachi T, Maeda K, Hara Y, Izumi Y, Hirofuji T, Imai E, Omae M, Watanuki M, Murakami S (2008) Periodontal tissue regeneration using fibroblast growth factor -2: randomized controlled phase II clinical trial. 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J Clin Periodontol 35: 668\u2013673.","DOI":"10.1111\/j.1600-051X.2008.01249.x"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) O\u2019Leary TJ, Drake RB, Naylor JE (1972) The plaque control record. J Periodontol 43: 38.","DOI":"10.1902\/jop.1972.43.1.38"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Papapanou PN, Sanz M, Buduneli N, Dietrich T, Feres M, Fine DH, Flemmig TF, Garcia R, Giannobile WV, Graziani F, Greenwell H, Herrera D, Kao RT, Kebschull M, Kinane DF, Kirkwood KL, Kocher T, Kornman KS, Kumar PS, Loos BG, Machtei E, Meng H, Mombelli A, Needleman I, Offenbacher S, Seymour GJ, Teles R, Tonetti MS (2018) Periodontitis: consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. 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J Periodontol 81: 1001\u20131009.","DOI":"10.1902\/jop.2010.090663"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Sculean A, Kiss A, Miliauskaite A, Schwarz F, Arweiler NB, Hannig M (2008) Ten-year results following treatment of intra-bony defects with enamel matrix proteins and guided tissue regeneration. J Clin Periodontol 35: 817\u2013824.","DOI":"10.1111\/j.1600-051X.2008.01295.x"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Seshima F, Bizenjima T, Aoki H, Imamura K, Kita D, Irokawa D, Matsugami D, Kitamura Y, Yamashita K, Sugito H, Tomita S, Saito A (2022) Periodontal regenerative therapy using rhFGF-2 and deproteinized bovine bone mineral versus rhFGF-2 alone: 4-year extended follow-up of a randomized controlled trial. Biomolecules 12: 1682.","DOI":"10.3390\/biom12111682"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Shirakata Y, Setoguchi F, Sena K, Nakamura T, Imafuji T, Shinohara Y, Iwata M, Noguchi K (2022) Comparison of periodontal wound healing\/regeneration by recombinant human fibroblast growth factor-2 combined with \u03b2-tricalcium phosphate, carbonate apatite, or deproteinized bovine bone mineral in a canine one-wall intra-bony defect model. J Clin Periodontol 49: 599\u2013608.","DOI":"10.1111\/jcpe.13619"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Stavropoulos A, Karring T (2010) Guided tissue regeneration combined with a deproteinized bovine bone mineral (Bio-Oss<sup>\u00ae<\/sup>) in the treatment of intrabony periodontal defects: 6-year results from a randomized-controlled clinical trial. J Clin Periodontol 37: 200\u2013210.","DOI":"10.1111\/j.1600-051X.2009.01520.x"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Susin C, Fiorini T, Lee J, De Stefano JA, Dickinson DP, Wikesj\u00f6 UM (2015) Wound healing following surgical and regenerative periodontal therapy. Periodontol 2000 68: 83\u201398.","DOI":"10.1111\/prd.12057"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Takayama S, Murakami S, Shimabukuro Y, Kitamura M, Okada H (2001) Periodontal regeneration by FGF-2 (bFGF) in primate models. J Dent Res 80: 2075\u20132079.","DOI":"10.1177\/00220345010800121001"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Tarnow DP, Magner AW, Fletcher P (1992) The effect of the distance from the contact point to the crest of bone on the presence or absence of the interproximal dental papilla. 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