{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T14:52:55Z","timestamp":1786373575979,"version":"build-2736575974"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["CJASN"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Childhood kidney failure is a rare condition with worldwide clinical variability. We used a nationwide multicenter analysis to study the pretransplant course of the entire Israeli pediatric kidney failure population over 30 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this nationwide, population-based, historical cohort study, we analyzed medical and demographic data of all children treated with KRT and reported to the Israeli kidney failure registry in 1990\u20132020. Statistical analysis was performed with incidence rate corrected for age, ethnicity, and calendar year, using the appropriate age-related general population as denominator.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During the last 30 years, childhood incidence of kidney failure decreased. Average incidence in 2015\u20132019 was 9.1 cases per million age-related population (pmarp). Arab and Druze children exhibited higher kidney failure incidence rates than Jewish children (18.4 versus 7.0 cases pmarp for minorities versus Jews). The most common kidney failure etiologies among Arab and Jewish children were congenital anomalies of the kidney and urinary tract (approximately 27%), followed by cystic kidney diseases among Arab children (13%) and glomerulonephritis among Jewish children (16%). The most common etiology among Druze children was primary hyperoxaluria type 1 (33%). Israel's national health insurance provides access to primary health care to all citizens. Accordingly, waiting time for deceased-donor transplantation was equal between all ethnicities. Living-donor kidney transplantation rates among minority populations remained low in comparison with Jews over the entire study period. Although all patient groups demonstrated improvement in survival, overall survival rates were mainly etiology dependent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In Israel, Arab and Druze children had a higher incidence of kidney failure, a unique etiological distribution, and a lower rate of living-donor kidney transplantations compared with Jewish children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2215\/cjn.0000000000000063","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T09:03:02Z","timestamp":1674205382000},"page":"363-373","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Dialysis in Israeli Children between 1990 and 2020: Trends and International Comparisons"],"prefix":"10.2215","volume":"18","author":[{"given":"Lilach C.","family":"Regev-Epstein","sequence":"first","affiliation":[{"name":"Department of Pediatrics B, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel"},{"name":"Department of Pediatric Nephrology, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaacov","family":"Frishberg","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology, Shaare Zedek Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Davidovits","sequence":"additional","affiliation":[{"name":"Institute of Nephrology, Schneider Children's Medical Center of Israel, Petah Tikva, Israel"},{"name":"Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Landau","sequence":"additional","affiliation":[{"name":"Institute of Nephrology, Schneider Children's Medical Center of Israel, Petah Tikva, Israel"},{"name":"Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniella","family":"Magen","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology Institute, Ruth Children's Hospital, Rambam Health Care Campus, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irit","family":"Weismann","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology Unit, Galilee Medical Center, Nahariya, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Stern-Zimmer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics B, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pazit","family":"Beckerman","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel"},{"name":"Institute of Nephrology and Hypertension, Sheba Medical Center, Tel Hashomer, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lital","family":"Keinan-Boker","sequence":"additional","affiliation":[{"name":"Israel Center for Disease Control, Ramat Gan, Israel"},{"name":"School of Public Health, University of Haifa, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronit","family":"Calderon-Margalit","sequence":"additional","affiliation":[{"name":"School of Public Health, Hadassah-Hebrew University, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asaf","family":"Vivante","sequence":"additional","affiliation":[{"name":"Department of Pediatrics B, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel"},{"name":"Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,1,20]]},"reference":[{"issue":"2","key":"B1-20250824","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/petr.12034","article-title":"Pediatric kidney transplant practice patterns and outcome benchmarks, 1987-2010: a report of the North American Pediatric Renal Trials and Collaborative Studies","volume":"17","author":"Smith","year":"2013","journal-title":"Pediatr Transplant."},{"issue":"3","key":"B2-20250824","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s00467-011-1939-1","article-title":"Epidemiology of chronic kidney disease in children","volume":"27","author":"Harambat","year":"2012","journal-title":"Pediatr 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How should it be continued?","volume":"8","author":"Zlotogora","year":"2019","journal-title":"Isr J Health Policy Res."},{"issue":"1","key":"B30-20250824","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.pec.2012.08.004","article-title":"Living donor kidney transplantation among ethnic minorities in the Netherlands: a model for breaking the hurdles","volume":"90","author":"Ismail","year":"2013","journal-title":"Patient Educ Couns."},{"issue":"2","key":"B31-20250824","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/j.1600-6143.2006.01623.x","article-title":"Increasing live donor kidney transplantation: a randomized controlled trial of a home-based educational intervention","volume":"7","author":"Rodrigue","year":"2007","journal-title":"Am J Transplant."},{"issue":"5","key":"B32-20250824","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S0272-6386(97)90128-1","article-title":"Increased living donor volunteer rates with a formal recipient family education program","volume":"29","author":"Schweitzer","year":"1997","journal-title":"Am J Kidney Dis."},{"issue":"3","key":"B33-20250824","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1053\/j.ajkd.2012.08.039","article-title":"Effectiveness of educational and social worker interventions to activate patients\u2019 discussion and pursuit of preemptive living donor kidney transplantation: a randomized controlled trial","volume":"61","author":"Boulware","year":"2013","journal-title":"Am J Kidney Dis."},{"issue":"9","key":"B34-20250824","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1097\/TP.0000000000000165","article-title":"Making house calls increases living donor inquiries and evaluations for blacks on the kidney transplant waiting list","volume":"98","author":"Rodrigue","year":"2014","journal-title":"Transplantation."},{"issue":"11","key":"B35-20250824","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1097\/TP.0b013e31824e75a5","article-title":"Live donor champion: finding live kidney donors by separating the advocate from the patient","volume":"93","author":"Garonzik-Wang","year":"2012","journal-title":"Transplantation."}],"container-title":["Clinical Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.2215\/CJN.0000000000000063","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T13:47:01Z","timestamp":1786369621000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.2215\/CJN.0000000000000063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,20]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.2215\/cjn.0000000000000063","relation":{},"ISSN":["1555-9041","1555-905X"],"issn-type":[{"value":"1555-9041","type":"print"},{"value":"1555-905X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,20]]},"assertion":[{"value":"2022-08-26","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-22","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}