{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T14:52:41Z","timestamp":1786373561558,"version":"build-2736575974"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["CJASN"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      FSGS is a heterogeneous diagnosis with a guarded prognosis. Polymorphisms in the apolipoprotein L1 (\n                      <jats:italic toggle=\"yes\">APOL1<\/jats:italic>\n                      ) gene are associated with developing FSGS and faster progression to kidney failure in affected patients. Better understanding the natural history of patients with FSGS and\n                      <jats:italic toggle=\"yes\">APOL1<\/jats:italic>\n                      risk alleles is essential to improve patient care and support the design and interpretation of interventional studies. The objective of this study was to evaluate the quantitative association between\n                      <jats:italic toggle=\"yes\">APOL1<\/jats:italic>\n                      and kidney disease progression and the interaction with other clinical and laboratory factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      CureGN cohort study participants with biopsy diagnosis of FSGS, regardless of self-identified race, were included. The exposure of interest was two\n                      <jats:italic toggle=\"yes\">APOL1<\/jats:italic>\n                      risk alleles (high risk) versus zero to one risk alleles (low risk). The primary outcome was eGFR slope categorized as rapid progressor (eGFR slope \u2264\u22125 ml\/min per year), intermediate progressor (slope between 0 and \u22125), or nonprogressor (slope \u22650). Multivariable ordinal logistic and linear regressions were used for adjusted analyses. Missing data were addressed using multiple imputation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 650 participants, 476 (73%) had genetic testing, among whom 87 (18%) were high risk. High-risk participants were more likely to have lower median eGFR (62 [interquartile range, 36\u201381] versus low-risk participants 76 ml\/min per 1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      [interquartile range, 44\u2013106];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.01). In adjusted analysis, the odds of more rapid progression of eGFR was 2.75 times higher (95% confidence interval, 1.67 to 4.53;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001) in the high-risk versus low-risk groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In patients with FSGS, high-risk\n                      <jats:italic toggle=\"yes\">APOL1<\/jats:italic>\n                      genotype is the predominant factor associated with more rapid loss of kidney function.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.2215\/cjn.0000000000000069","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T09:02:48Z","timestamp":1674205368000},"page":"344-355","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":24,"title":["Rapid Progression of Focal Segmental Glomerulosclerosis in Patients with High-Risk APOL1 Genotypes"],"prefix":"10.2215","volume":"18","author":[{"given":"Mahmoud","family":"Kallash","sequence":"first","affiliation":[{"name":"Division of Pediatric Nephrology, Nationwide Children's Hospital, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Wang","sequence":"additional","affiliation":[{"name":"University of Michigan, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail","family":"Smith","sequence":"additional","affiliation":[{"name":"Arbor Research Collaborative for Health, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7447-9489","authenticated-orcid":false,"given":"Howard","family":"Trachtman","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasheed","family":"Gbadegesin","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology, Duke Children's Hospital and Health Center, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Nester","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology, Dialysis and Transplantation, Stead Family Department of Pediatrics, University of Iowa, Iowa City, Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1130-5486","authenticated-orcid":false,"given":"Pietro","family":"Canetta","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9127-0054","authenticated-orcid":false,"given":"Chen","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy E.","family":"Hunley","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8409-0714","authenticated-orcid":false,"given":"C. John","family":"Sperati","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Selewski","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology, Medical University of South Carolina, Charleston, South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7988-3082","authenticated-orcid":false,"given":"Isabelle","family":"Ayoub","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Nephrology, The Ohio State University Wexner Medical Center, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarak","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Children's Mercy Hospital and University of Missouri-Kansas City School of Medicine, Kansas City, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4258-1726","authenticated-orcid":false,"given":"Amy K.","family":"Mottl","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Kidney Center, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9052-186X","authenticated-orcid":false,"given":"Jeffrey","family":"Kopp","sequence":"additional","affiliation":[{"name":"Kidney Disease Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Gillespie","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Robinson","sequence":"additional","affiliation":[{"name":"Arbor Research Collaborative for Health, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6078-8392","authenticated-orcid":false,"given":"Dhruti","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Kidney Center, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8601-9479","authenticated-orcid":false,"given":"Julia","family":"Steinke","sequence":"additional","affiliation":[{"name":"Division of Medical Subspecialties, Section of Pediatric Nephrology, Helen DeVos Children's Hospital, Grand Rapids, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Twombley","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology, Medical University of South Carolina, Charleston, South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Reidy","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Mucha","sequence":"additional","affiliation":[{"name":"Department of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland"},{"name":"Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2490-021X","authenticated-orcid":false,"given":"Larry A.","family":"Greenbaum","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology, Department of Pediatrics, Emory University and Children's Healthcare of Atlanta, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke","family":"Blazius","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Helmuth","sequence":"additional","affiliation":[{"name":"Arbor Research Collaborative for Health, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peleg","family":"Yonatan","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rulan S.","family":"Parekh","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology, Hospital for Sick Children, Toronto, Ontario, Canada"},{"name":"Child Health Evaluative Sciences, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada"},{"name":"Department of Medicine, Division of Nephrology, University Health Network, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7205-8357","authenticated-orcid":false,"given":"Susan","family":"Hogan","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Kidney Center, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Royal","sequence":"additional","affiliation":[{"name":"Division of Pathology, H\u00f4pital Maisonneuve-Rosemont, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivette","family":"D'Agati","sequence":"additional","affiliation":[{"name":"Department of Pathology, Columbia University Medical Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aftab","family":"Chishti","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Hypertension and Renal Transplantation, University of Kentucky, Lexington, Kentucky"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Falk","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Kidney Center, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Gharavi","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Holzman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Medicine-Renal, University of Louisville School of Medicine, Louisville, Kentucky"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Smoyer","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology, Nationwide Children's Hospital, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4064-0582","authenticated-orcid":false,"given":"Matthias","family":"Kretzler","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4473-9045","authenticated-orcid":false,"given":"Debbie","family":"Gipson","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9395-9813","authenticated-orcid":false,"given":"Jason M.","family":"Kidd","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Virginia Commonwealth University, Richmond, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of CureGN*","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,2,8]]},"reference":[{"issue":"11","key":"B1-20250824","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1681\/ASN.2011040388","article-title":"APOL1 genetic variants in focal segmental glomerulosclerosis and HIV-associated nephropathy","volume":"22","author":"Kopp","year":"2011","journal-title":"J Am Soc Nephrol."},{"issue":"5993","key":"B2-20250824","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1126\/science.1193032","article-title":"Association of trypanolytic APOL1 variants with kidney disease in African Americans","volume":"329","author":"Genovese","year":"2010","journal-title":"Science"},{"issue":"9","key":"B3-20250824","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1681\/ASN.2013010113","article-title":"APOL1 variants associate with increased risk of CKD among African Americans","volume":"24","author":"Foster","year":"2013","journal-title":"J Am Soc Nephrol."},{"issue":"12","key":"B4-20250824","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1681\/ASN.2014080768","article-title":"APOL1 risk alleles are associated with exaggerated age-related changes in glomerular number and volume in African-American adults: an autopsy study","volume":"26","author":"Hoy","year":"2015","journal-title":"J Am Soc Nephrol."},{"issue":"1","key":"B5-20250824","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/ki.2012.263","article-title":"Apolipoprotein L1 gene variants associate with hypertension-attributed nephropathy and the rate of kidney function decline in African Americans","volume":"83","author":"Lipkowitz","year":"2013","journal-title":"Kidney Int."},{"issue":"11","key":"B6-20250824","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1681\/ASN.2009121210","article-title":"Rate of kidney function decline associates with mortality","volume":"21","author":"Al-Aly","year":"2010","journal-title":"J Am Soc Nephrol."},{"issue":"20","key":"B7-20250824","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1001\/archinte.168.20.2212","article-title":"Rapid kidney function decline and mortality risk in older adults","volume":"168","author":"Rifkin","year":"2008","journal-title":"Arch Intern Med."},{"issue":"12","key":"B8-20250824","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1681\/ASN.2009010025","article-title":"Change in estimated GFR associates with coronary heart disease and mortality","volume":"20","author":"Matsushita","year":"2009","journal-title":"J Am Soc Nephrol."},{"key":"B9-20250824","first-page":"1","article-title":"KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease","volume":"3","year":"2013","journal-title":"Kidney Int."},{"issue":"2","key":"B10-20250824","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1053\/j.ajkd.2018.07.020","article-title":"CureGN study rationale, design, and methods: establishing a large prospective observational study of glomerular disease","volume":"73","author":"Mariani","year":"2019","journal-title":"Am J Kidney Dis."},{"issue":"3","key":"B11-20250824","doi-asserted-by":"crossref","first-page":"e20171904","DOI":"10.1542\/peds.2017-1904","article-title":"Clinical practice guideline for screening and management of high blood pressure in children and adolescents","volume":"140","author":"Flynn","year":"2017","journal-title":"Pediatrics."},{"issue":"4","key":"B12-20250824","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.kint.2020.10.047","article-title":"Age- and sex-dependent clinical equations to estimate glomerular filtration rates in children and young adults with chronic kidney disease","volume":"99","author":"Pierce","year":"2021","journal-title":"Kidney Int."},{"issue":"19","key":"B13-20250824","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1056\/NEJMoa2102953","article-title":"New creatinine- and cystatin C\u2013based equations to estimate GFR without race","volume":"385","author":"Inker","year":"2021","journal-title":"N Engl J Med."},{"issue":"2","key":"B14-20250824","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1053\/j.ajkd.2003.10.024","article-title":"Pathologic classification of focal segmental glomerulosclerosis: a working proposal","volume":"43","author":"D\u2019Agati","year":"2004","journal-title":"Am J Kidney Dis."},{"issue":"1","key":"B15-20250824","first-page":"85","article-title":"A multivariate technique for multiply imputing missing values using a sequence of regression models","volume":"27","author":"Lepkowski","year":"2001","journal-title":"Surv Methodol."},{"issue":"3","key":"B17-20250824","doi-asserted-by":"crossref","first-page":"414","DOI":"10.2215\/CJN.04780517","article-title":"An outcomes-based definition of proteinuria remission in focal segmental glomerulosclerosis","volume":"13","author":"Troost","year":"2018","journal-title":"Clin J Am Soc Nephrol."},{"issue":"2","key":"B18-20250824","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1053\/j.ajkd.2020.04.014","article-title":"Proteinuria reduction and kidney survival in focal segmental glomerulosclerosis","volume":"77","author":"Troost","year":"2021","journal-title":"Am J Kidney Dis."},{"issue":"23","key":"B19-20250824","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1056\/NEJMoa1310345","article-title":"APOL1 risk variants, race, and progression of chronic kidney disease","volume":"369","author":"Parsa","year":"2013","journal-title":"N Engl J Med."},{"issue":"3","key":"B20-20250824","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1681\/ASN.2014111131","article-title":"Integrative genomics identifies novel associations with APOL1 risk genotypes in black NEPTUNE subjects","volume":"27","author":"Sampson","year":"2016","journal-title":"J Am Soc Nephrol."},{"issue":"6","key":"B21-20250824","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1681\/ASN.2013111242","article-title":"Clinical features and histology of apolipoprotein L1-associated nephropathy in the FSGS clinical trial","volume":"26","author":"Kopp","year":"2015","journal-title":"J Am Soc Nephrol."},{"issue":"6","key":"B22-20250824","first-page":"983","article-title":"APOL1-associated glomerular disease among African-American children: a collaboration of the Chronic Kidney Disease in Children (CKiD) and Nephrotic Syndrome Study Network (NEPTUNE) cohorts","volume":"32","author":"Ng","year":"2017","journal-title":"Nephrol Dial Transplant."},{"issue":"4","key":"B23-20250824","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.kint.2021.05.021","article-title":"KDIGO 2021 clinical practice guideline for the management of glomerular diseases","volume":"100","year":"2021","journal-title":"Kidney Int."},{"issue":"8","key":"B24-20250824","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1007\/s00467-020-04519-1","article-title":"IPNA clinical practice recommendations for the diagnosis and management of children with steroid-resistant nephrotic syndrome","volume":"35","author":"Trautmann","year":"2020","journal-title":"Pediatr Nephrol."},{"issue":"3","key":"B25-20250824","doi-asserted-by":"crossref","first-page":"e221048","DOI":"10.1001\/jamanetworkopen.2022.1048","article-title":"Effects of testing and disclosing ancestry-specific genetic risk for kidney failure on patients and health care professionals: a randomized clinical trial","volume":"5","author":"Nadkarni","year":"2022","journal-title":"JAMA Netw Open."},{"issue":"2","key":"B26-20250824","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/s41581-021-00501-8","article-title":"Health inequities and the inappropriate use of race in nephrology","volume":"18","author":"Eneanya","year":"2022","journal-title":"Nat Rev Nephrol."}],"container-title":["Clinical Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.2215\/CJN.0000000000000069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T13:46:54Z","timestamp":1786369614000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.2215\/CJN.0000000000000069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,8]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.2215\/cjn.0000000000000069","relation":{},"ISSN":["1555-9041","1555-905X"],"issn-type":[{"value":"1555-9041","type":"print"},{"value":"1555-905X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,8]]},"assertion":[{"value":"2022-09-16","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-02","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}